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PIK3CA mutations and first-line outcomes in endocrine-resistant HR+/HER2- metastatic breast cancer: A multicentric real-world study.

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Title: PIK3CA mutations and first-line outcomes in endocrine-resistant HR+/HER2- metastatic breast cancer: A multicentric real-world study.
Authors: Dieci MV; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy. Electronic address: mariavittoria.dieci@unipd.it., Vernaci G; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy., Colangelo C; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy; Basic and Translational Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy; Functional Proteomic Section, Department of Life Sciences, University of Siena, Siena 53100, Italy., Bria E; University Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; Ospedale Isola Tiberina - Gemelli Isola, Rome, Italy., Massa D; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy., Di Liso E; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy., Giorgi CA; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy., Giarratano T; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy., Napetti D; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy., Bonomi G; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy., Zanghì F; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy., Bottosso M; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy., Lazzarini E; Basic and Translational Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy., Santarelli L; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy; Basic and Translational Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy., Boscolo Bragadin A; Basic and Translational Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy., Indraccolo S; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy; Basic and Translational Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy., Guarneri V; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy.
Source: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2026 Feb 05; Vol. 234, pp. 116194. Date of Electronic Publication: 2025 Dec 19.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: PIK3CA mutations and first-line outcomes in endocrine-resistant HR+/HER2- metastatic breast cancer: A multicentric real-world study.
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  Data: <searchLink fieldCode="AU" term="%22Dieci+MV%22">Dieci MV</searchLink>; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy. Electronic address: mariavittoria.dieci@unipd.it.<br /><searchLink fieldCode="AU" term="%22Vernaci+G%22">Vernaci G</searchLink>; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Colangelo+C%22">Colangelo C</searchLink>; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy; Basic and Translational Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy; Functional Proteomic Section, Department of Life Sciences, University of Siena, Siena 53100, Italy.<br /><searchLink fieldCode="AU" term="%22Bria+E%22">Bria E</searchLink>; University Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; Ospedale Isola Tiberina - Gemelli Isola, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Massa+D%22">Massa D</searchLink>; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Liso+E%22">Di Liso E</searchLink>; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Giorgi+CA%22">Giorgi CA</searchLink>; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Giarratano+T%22">Giarratano T</searchLink>; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Napetti+D%22">Napetti D</searchLink>; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Bonomi+G%22">Bonomi G</searchLink>; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Zanghì+F%22">Zanghì F</searchLink>; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Bottosso+M%22">Bottosso M</searchLink>; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Lazzarini+E%22">Lazzarini E</searchLink>; Basic and Translational Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Santarelli+L%22">Santarelli L</searchLink>; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy; Basic and Translational Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Boscolo+Bragadin+A%22">Boscolo Bragadin A</searchLink>; Basic and Translational Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Indraccolo+S%22">Indraccolo S</searchLink>; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy; Basic and Translational Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Guarneri+V%22">Guarneri V</searchLink>; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy; Division of Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy.
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  Data: <searchLink fieldCode="JN" term="%229005373%22">European journal of cancer (Oxford, England : 1990)</searchLink> [Eur J Cancer] 2026 Feb 05; Vol. 234, pp. 116194. <i>Date of Electronic Publication: </i>2025 Dec 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9005373 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0852 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209598049%22">09598049 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Cancer <i>Subsets: </i>MEDLINE
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