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The Alzheimer's disease risk genes MS4A4A and MS4A6A cooperate to negatively regulate TREM2 and microglia states.

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Title: The Alzheimer's disease risk genes MS4A4A and MS4A6A cooperate to negatively regulate TREM2 and microglia states.
Authors: Rosner D; Alector, Inc., South San Francisco, CA 94080, USA. Electronic address: dalya.rosner@gmail.com., Sun J; Alector, Inc., South San Francisco, CA 94080, USA., Cacace R; Laboratory of Microglia and Inflammation in Neurological Disorders (MIND), VIB-Center for Molecular Neurology (CMN), VIB, Universiteit Antwerpen-CDE, Antwerpen, Belgium., Yee A; Alector, Inc., South San Francisco, CA 94080, USA., Wagh C; Alector, Inc., South San Francisco, CA 94080, USA., Rychkova A; Alector, Inc., South San Francisco, CA 94080, USA., Dunlap M; Alector, Inc., South San Francisco, CA 94080, USA., Gulbranson D; Alector, Inc., South San Francisco, CA 94080, USA., Ibrahim A; Alector, Inc., South San Francisco, CA 94080, USA., Wang X; Alector, Inc., South San Francisco, CA 94080, USA., Wang R; Alector, Inc., South San Francisco, CA 94080, USA., Buonfiglioli A; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Alhawagri M; Alector, Inc., South San Francisco, CA 94080, USA., Kong P; Alector, Inc., South San Francisco, CA 94080, USA., Roell M; Alector, Inc., South San Francisco, CA 94080, USA., Ho WH; Alector, Inc., South San Francisco, CA 94080, USA., Gong B; Alector, Inc., South San Francisco, CA 94080, USA., Denton H; Laboratory of Microglia and Inflammation in Neurological Disorders (MIND), VIB-Center for Molecular Neurology (CMN), VIB, Universiteit Antwerpen-CDE, Antwerpen, Belgium., Muscarnera G; Laboratory of Microglia and Inflammation in Neurological Disorders (MIND), VIB-Center for Molecular Neurology (CMN), VIB, Universiteit Antwerpen-CDE, Antwerpen, Belgium., Meese T; Laboratory of Microglia and Inflammation in Neurological Disorders (MIND), VIB-Center for Molecular Neurology (CMN), VIB, Universiteit Antwerpen-CDE, Antwerpen, Belgium., El-Khatib M; Alector, Inc., South San Francisco, CA 94080, USA., Bermingham D; Alector, Inc., South San Francisco, CA 94080, USA., Kahn E; Alector, Inc., South San Francisco, CA 94080, USA., Cignarella F; Alector, Inc., South San Francisco, CA 94080, USA., Rhinn H; Alector, Inc., South San Francisco, CA 94080, USA., Khan Z; Alector, Inc., South San Francisco, CA 94080, USA., Schwabe T; Alector, Inc., South San Francisco, CA 94080, USA., Srinivisan K; Alector, Inc., South San Francisco, CA 94080, USA., Mitra A; Alector, Inc., South San Francisco, CA 94080, USA., de Witte L; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Heutink P; Alector, Inc., South San Francisco, CA 94080, USA., Mancuso R; Laboratory of Microglia and Inflammation in Neurological Disorders (MIND), VIB-Center for Molecular Neurology (CMN), VIB, Universiteit Antwerpen-CDE, Antwerpen, Belgium., Tassi I; Alector, Inc., South San Francisco, CA 94080, USA., Kuhn J; Alector, Inc., South San Francisco, CA 94080, USA., Long H; Alector, Inc., South San Francisco, CA 94080, USA., Kenkare-Mitra S; Alector, Inc., South San Francisco, CA 94080, USA., Rosenthal A; Alector, Inc., South San Francisco, CA 94080, USA.
Source: Neuron [Neuron] 2026 Mar 04; Vol. 114 (5), pp. 836-849.e11. Date of Electronic Publication: 2025 Dec 22.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The Alzheimer's disease risk genes MS4A4A and MS4A6A cooperate to negatively regulate TREM2 and microglia states.
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Alector, Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22de+Witte+L%22">de Witte L</searchLink>; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Heutink+P%22">Heutink P</searchLink>; Alector, Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Mancuso+R%22">Mancuso R</searchLink>; Laboratory of Microglia and Inflammation in Neurological Disorders (MIND), VIB-Center for Molecular Neurology (CMN), VIB, Universiteit Antwerpen-CDE, Antwerpen, Belgium.<br /><searchLink fieldCode="AU" term="%22Tassi+I%22">Tassi I</searchLink>; Alector, Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Kuhn+J%22">Kuhn J</searchLink>; Alector, Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Long+H%22">Long H</searchLink>; Alector, Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Kenkare-Mitra+S%22">Kenkare-Mitra S</searchLink>; Alector, Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Rosenthal+A%22">Rosenthal A</searchLink>; Alector, Inc., South San Francisco, CA 94080, USA.
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  Data: <searchLink fieldCode="JN" term="%228809320%22">Neuron</searchLink> [Neuron] 2026 Mar 04; Vol. 114 (5), pp. 836-849.e11. <i>Date of Electronic Publication: </i>2025 Dec 22.
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