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Small-molecule inhibitor of C‑terminal HSP90 dimerization modulates autophagy and functions synergistically with mTOR inhibition to kill cisplatin-resistant cancer cells.

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Title: Small-molecule inhibitor of C‑terminal HSP90 dimerization modulates autophagy and functions synergistically with mTOR inhibition to kill cisplatin-resistant cancer cells.
Authors: David C; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Sun Y; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.; Department of Urology, Weifang People's Hospital, Shandong Second Medical University, Weifang, China., Woloschin V; Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute for Pharmaceutical and Medicinal Chemistry, Düsseldorf, Germany., Vogt M; Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Dienstbier N; Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Friedrich A; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Krings KS; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Schlütermann D; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Berning L; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Lungerich B; Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute for Pharmaceutical and Medicinal Chemistry, Düsseldorf, Germany., Akgün S; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Mendiburo MJ; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Gertzen CGW; Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute for Pharmaceutical and Medicinal Chemistry, Düsseldorf, Germany.; Heinrich Heine University Düsseldorf, Center for Structural Studies (CSS), Düsseldorf, Germany., Borkhardt A; Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Wesselborg S; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Gohlke H; Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute for Pharmaceutical and Medicinal Chemistry, Düsseldorf, Germany.; Institute of Bio- and Geosciences (IBG-4: Bioinformatics), Forschungszentrum Jülich GmbH, Jülich, Germany., Bhatia S; Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany. sanil.bhatia@med.uni-duesseldorf.de., Kurz T; Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute for Pharmaceutical and Medicinal Chemistry, Düsseldorf, Germany. thomas.kurz@hhu.de., Stork B; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany. bjoern.stork@hhu.de.
Source: Cell death & disease [Cell Death Dis] 2025 Dec 23; Vol. 17 (1), pp. 130. Date of Electronic Publication: 2025 Dec 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
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  Data: Small-molecule inhibitor of C‑terminal HSP90 dimerization modulates autophagy and functions synergistically with mTOR inhibition to kill cisplatin-resistant cancer cells.
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  Data: <searchLink fieldCode="AU" term="%22David+C%22">David C</searchLink>; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.; Department of Urology, Weifang People's Hospital, Shandong Second Medical University, Weifang, China.<br /><searchLink fieldCode="AU" term="%22Woloschin+V%22">Woloschin V</searchLink>; Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute for Pharmaceutical and Medicinal Chemistry, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Vogt+M%22">Vogt M</searchLink>; Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Dienstbier+N%22">Dienstbier N</searchLink>; Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Friedrich+A%22">Friedrich A</searchLink>; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Krings+KS%22">Krings KS</searchLink>; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Schlütermann+D%22">Schlütermann D</searchLink>; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Berning+L%22">Berning L</searchLink>; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Lungerich+B%22">Lungerich B</searchLink>; Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute for Pharmaceutical and Medicinal Chemistry, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Akgün+S%22">Akgün S</searchLink>; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Mendiburo+MJ%22">Mendiburo MJ</searchLink>; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Gertzen+CGW%22">Gertzen CGW</searchLink>; Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute for Pharmaceutical and Medicinal Chemistry, Düsseldorf, Germany.; Heinrich Heine University Düsseldorf, Center for Structural Studies (CSS), Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Borkhardt+A%22">Borkhardt A</searchLink>; Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Wesselborg+S%22">Wesselborg S</searchLink>; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Gohlke+H%22">Gohlke H</searchLink>; Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute for Pharmaceutical and Medicinal Chemistry, Düsseldorf, Germany.; Institute of Bio- and Geosciences (IBG-4: Bioinformatics), Forschungszentrum Jülich GmbH, Jülich, Germany.<br /><searchLink fieldCode="AU" term="%22Bhatia+S%22">Bhatia S</searchLink>; Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany. sanil.bhatia@med.uni-duesseldorf.de.<br /><searchLink fieldCode="AU" term="%22Kurz+T%22">Kurz T</searchLink>; Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute for Pharmaceutical and Medicinal Chemistry, Düsseldorf, Germany. thomas.kurz@hhu.de.<br /><searchLink fieldCode="AU" term="%22Stork+B%22">Stork B</searchLink>; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany. bjoern.stork@hhu.de.
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