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C/EBPβ-induced alternative splicing of RCAN1 generates a potent TCR-T target in mesenchymal glioblastoma.

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Title: C/EBPβ-induced alternative splicing of RCAN1 generates a potent TCR-T target in mesenchymal glioblastoma.
Authors: Xiong Z; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Kong Q; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Chagantipati B; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Stepniak A; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Jaswal AP; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Radiology, Weill Cornell Medical College, New York, NY, USA., Sneiderman CT; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Han Y; Department of Nephrology, Xiangya Hospital, Central South University, Changsha, Hunan, China., Jackson SA; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA., Raphael RA; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Institute for Drug Research (IDR), School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Zhang W; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China., Li M; The Second School of Clinical Medicine, Anhui Medical University, Hefei, Anhui, China., Chao Y; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Qin B; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.; National Center for International Research in Cell and Gene Therapy, Sino-British Research Center for Molecular Oncology, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China., Dulkadir Z; Department of Molecular Microbiology and Immunology, University of Texas at San Antonio, San Antonio, TX, USA., Schwegman L; Department of Molecular Microbiology and Immunology, University of Texas at San Antonio, San Antonio, TX, USA., Zhang Y; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China., Kuminkoski C; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Mahlke MA; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Nath P; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Hu B; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Zinn PO; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Mantica M; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA., Agnihotri S; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Nechemia-Arbely Y; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Pollack IF; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Rigatti LH; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Division of Laboratory Animal Resources, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Forsthuber TG; Department of Molecular Microbiology and Immunology, University of Texas at San Antonio, San Antonio, TX, USA., Li X; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.; Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, Changsha, China., Raphael I; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA. Itay.Raphael@mail.huji.ac.il.; Institute for Drug Research (IDR), School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. Itay.Raphael@mail.huji.ac.il., Kohanbash G; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA. gary.kohanbash2@chp.edu.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA. gary.kohanbash2@chp.edu.; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA. gary.kohanbash2@chp.edu.
Source: Cellular & molecular immunology [Cell Mol Immunol] 2026 Jan; Vol. 23 (1), pp. 94-113. Date of Electronic Publication: 2025 Dec 23.
Publication Type: Journal Article
Journal Info: Publisher: Chinese Society of Immunology Country of Publication: China NLM ID: 101242872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2042-0226 (Electronic) Linking ISSN: 16727681 NLM ISO Abbreviation: Cell Mol Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: C/EBPβ-induced alternative splicing of RCAN1 generates a potent TCR-T target in mesenchymal glioblastoma.
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  Data: <searchLink fieldCode="AU" term="%22Xiong+Z%22">Xiong Z</searchLink>; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kong+Q%22">Kong Q</searchLink>; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Chagantipati+B%22">Chagantipati B</searchLink>; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Stepniak+A%22">Stepniak A</searchLink>; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Jaswal+AP%22">Jaswal AP</searchLink>; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Radiology, Weill Cornell Medical College, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sneiderman+CT%22">Sneiderman CT</searchLink>; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Han+Y%22">Han Y</searchLink>; Department of Nephrology, Xiangya Hospital, Central South University, Changsha, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Jackson+SA%22">Jackson SA</searchLink>; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Raphael+RA%22">Raphael RA</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Institute for Drug Research (IDR), School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; The Second School of Clinical Medicine, Anhui Medical University, Hefei, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Chao+Y%22">Chao Y</searchLink>; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Qin+B%22">Qin B</searchLink>; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.; National Center for International Research in Cell and Gene Therapy, Sino-British Research Center for Molecular Oncology, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.<br /><searchLink fieldCode="AU" term="%22Dulkadir+Z%22">Dulkadir Z</searchLink>; Department of Molecular Microbiology and Immunology, University of Texas at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Schwegman+L%22">Schwegman L</searchLink>; Department of Molecular Microbiology and Immunology, University of Texas at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Kuminkoski+C%22">Kuminkoski C</searchLink>; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Mahlke+MA%22">Mahlke MA</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Nath+P%22">Nath P</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hu+B%22">Hu B</searchLink>; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Zinn+PO%22">Zinn PO</searchLink>; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Mantica+M%22">Mantica M</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Agnihotri+S%22">Agnihotri S</searchLink>; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Nechemia-Arbely+Y%22">Nechemia-Arbely Y</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Pollack+IF%22">Pollack IF</searchLink>; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Rigatti+LH%22">Rigatti LH</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Division of Laboratory Animal Resources, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Forsthuber+TG%22">Forsthuber TG</searchLink>; Department of Molecular Microbiology and Immunology, University of Texas at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.; Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Raphael+I%22">Raphael I</searchLink>; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA. Itay.Raphael@mail.huji.ac.il.; Institute for Drug Research (IDR), School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. Itay.Raphael@mail.huji.ac.il.<br /><searchLink fieldCode="AU" term="%22Kohanbash+G%22">Kohanbash G</searchLink>; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA. gary.kohanbash2@chp.edu.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA. gary.kohanbash2@chp.edu.; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA. gary.kohanbash2@chp.edu.
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  Data: <searchLink fieldCode="JN" term="%22101242872%22">Cellular & molecular immunology</searchLink> [Cell Mol Immunol] 2026 Jan; Vol. 23 (1), pp. 94-113. <i>Date of Electronic Publication: </i>2025 Dec 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Chinese+Society+of+Immunology%22">Chinese Society of Immunology </searchLink><i>Country of Publication: </i>China <i>NLM ID: </i>101242872 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2042-0226 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216727681%22">16727681 </searchLink><i>NLM ISO Abbreviation: </i>Cell Mol Immunol <i>Subsets: </i>MEDLINE
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