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The tumour immune microenvironment is enriched but suppressed in vestibular schwannoma compared to meningioma: therapeutic implications for NF2-related schwannomatosis.

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Title: The tumour immune microenvironment is enriched but suppressed in vestibular schwannoma compared to meningioma: therapeutic implications for NF2-related schwannomatosis.
Authors: Gregory GE; Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.; Geoffrey Jefferson Brain Research Centre, The Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust, University of Manchester, Manchester, UK.; The Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK., Haley MJ; Bioimaging Core Facility, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, UK., Jones AP; Edwin L. Steele Laboratories, Department of Radiation Oncology, MassaCtts General Hospital and Harvard Medical School, Boston, MA, 02114, USA., Zeef LAH; Bioinformatics Core Facility, University of Manchester, Manchester, UK., Evans DG; Geoffrey Jefferson Brain Research Centre, The Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust, University of Manchester, Manchester, UK.; Division of Evolution, Infection and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK., King AT; Geoffrey Jefferson Brain Research Centre, The Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust, University of Manchester, Manchester, UK.; Division of Cardiovascular Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.; Department of Neurosurgery, Manchester Centre for Clinical Neurosciences, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Stott Lane, Salford, M6 8HD, UK., Paszek P; Institute of Fundamental Technological Research, Polish Academy of Sciences, Pawinskiego 5B, 02-106, Warsaw, Poland., Couper KN; Geoffrey Jefferson Brain Research Centre, The Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust, University of Manchester, Manchester, UK.; The Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK.; Division of Immunology, Immunity to Infection and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Brough D; Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.; Geoffrey Jefferson Brain Research Centre, The Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust, University of Manchester, Manchester, UK.; The Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK., Pathmanaban ON; Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. omar.pathmanaban@manchester.ac.uk.; Geoffrey Jefferson Brain Research Centre, The Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust, University of Manchester, Manchester, UK. omar.pathmanaban@manchester.ac.uk.; The Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK. omar.pathmanaban@manchester.ac.uk.; Department of Neurosurgery, Manchester Centre for Clinical Neurosciences, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Stott Lane, Salford, M6 8HD, UK. omar.pathmanaban@manchester.ac.uk.
Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2025 Dec 23; Vol. 13 (1), pp. 256. Date of Electronic Publication: 2025 Dec 23.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE
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  Data: The tumour immune microenvironment is enriched but suppressed in vestibular schwannoma compared to meningioma: therapeutic implications for NF2-related schwannomatosis.
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  Data: <searchLink fieldCode="AU" term="%22Gregory+GE%22">Gregory GE</searchLink>; Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.; Geoffrey Jefferson Brain Research Centre, The Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust, University of Manchester, Manchester, UK.; The Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Haley+MJ%22">Haley MJ</searchLink>; Bioimaging Core Facility, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, UK.<br /><searchLink fieldCode="AU" term="%22Jones+AP%22">Jones AP</searchLink>; Edwin L. Steele Laboratories, Department of Radiation Oncology, MassaCtts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Zeef+LAH%22">Zeef LAH</searchLink>; Bioinformatics Core Facility, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Evans+DG%22">Evans DG</searchLink>; Geoffrey Jefferson Brain Research Centre, The Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust, University of Manchester, Manchester, UK.; Division of Evolution, Infection and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22King+AT%22">King AT</searchLink>; Geoffrey Jefferson Brain Research Centre, The Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust, University of Manchester, Manchester, UK.; Division of Cardiovascular Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.; Department of Neurosurgery, Manchester Centre for Clinical Neurosciences, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Stott Lane, Salford, M6 8HD, UK.<br /><searchLink fieldCode="AU" term="%22Paszek+P%22">Paszek P</searchLink>; Institute of Fundamental Technological Research, Polish Academy of Sciences, Pawinskiego 5B, 02-106, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Couper+KN%22">Couper KN</searchLink>; Geoffrey Jefferson Brain Research Centre, The Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust, University of Manchester, Manchester, UK.; The Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK.; Division of Immunology, Immunity to Infection and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Brough+D%22">Brough D</searchLink>; Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.; Geoffrey Jefferson Brain Research Centre, The Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust, University of Manchester, Manchester, UK.; The Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Pathmanaban+ON%22">Pathmanaban ON</searchLink>; Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. omar.pathmanaban@manchester.ac.uk.; Geoffrey Jefferson Brain Research Centre, The Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust, University of Manchester, Manchester, UK. omar.pathmanaban@manchester.ac.uk.; The Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK. omar.pathmanaban@manchester.ac.uk.; Department of Neurosurgery, Manchester Centre for Clinical Neurosciences, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Stott Lane, Salford, M6 8HD, UK. omar.pathmanaban@manchester.ac.uk.
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              Text: 2025 Dec 23
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