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Senescent Mesenchymal Stromal Cells Differentially Alter Adipogenesis in Adipose Tissue, Skeletal Muscle, and Bone Marrow.

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Title: Senescent Mesenchymal Stromal Cells Differentially Alter Adipogenesis in Adipose Tissue, Skeletal Muscle, and Bone Marrow.
Authors: Zhang X; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA., Doolittle ML; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Center for Regenerative Medicine and Skeletal Development, UConn Health, Farmington, Connecticut, USA., Fan T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA., Tripathi U; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA., Ng YE; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA., Jiang X; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA., Passos JF; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA., Jurk D; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA., Monroe DG; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA.; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA., Tchkonia T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Department of Medicine, Division of Endocrinology, Cedars-Sinai Medical Center, Los Angeles, California, USA., Kirkland JL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Department of Medicine, Division of Endocrinology, Cedars-Sinai Medical Center, Los Angeles, California, USA., Robbins PD; Masonic Institute on the Biology of Aging and Metabolism, University of Minnesota Medical School, Minneapolis, Minnesota, USA.; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA., Khosla S; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA., LeBrasseur NK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota, USA.
Source: Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2026 Mar; Vol. 34 (3), pp. 652-661. Date of Electronic Publication: 2025 Dec 24.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101264860 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1930-739X (Electronic) Linking ISSN: 19307381 NLM ISO Abbreviation: Obesity (Silver Spring) Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Doolittle+ML%22">Doolittle ML</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Center for Regenerative Medicine and Skeletal Development, UConn Health, Farmington, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Fan+T%22">Fan T</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Tripathi+U%22">Tripathi U</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Ng+YE%22">Ng YE</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+X%22">Jiang X</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Passos+JF%22">Passos JF</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Jurk+D%22">Jurk D</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Monroe+DG%22">Monroe DG</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA.; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Tchkonia+T%22">Tchkonia T</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Department of Medicine, Division of Endocrinology, Cedars-Sinai Medical Center, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Kirkland+JL%22">Kirkland JL</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Department of Medicine, Division of Endocrinology, Cedars-Sinai Medical Center, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Robbins+PD%22">Robbins PD</searchLink>; Masonic Institute on the Biology of Aging and Metabolism, University of Minnesota Medical School, Minneapolis, Minnesota, USA.; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Khosla+S%22">Khosla S</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22LeBrasseur+NK%22">LeBrasseur NK</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota, USA.
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