Design and synthesis of sorafenib-inspired benzofuran hybrids as VEGFR-2 inhibitors: antiproliferative evaluation, mechanistic insights, and docking studies in hepatocellular carcinoma.
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| Title: | Design and synthesis of sorafenib-inspired benzofuran hybrids as VEGFR-2 inhibitors: antiproliferative evaluation, mechanistic insights, and docking studies in hepatocellular carcinoma. |
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| Authors: | Shehda MS; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Horus University-Egypt New Damietta 34518 Egypt mshehda@horus.edu.eg., Almatary AM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Horus University-Egypt New Damietta 34518 Egypt mshehda@horus.edu.eg., Salem MSH; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University Ismailia 41522 Egypt.; SANKEN, The University of Osaka Mihogaoka Ibaraki Osaka 567-0047 Japan mohamedsalem43@sanken.osaka-u.ac.jp., Aboutaleb MH; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Horus University-Egypt New Damietta 34518 Egypt mshehda@horus.edu.eg., Takizawa S; SANKEN, The University of Osaka Mihogaoka Ibaraki Osaka 567-0047 Japan mohamedsalem43@sanken.osaka-u.ac.jp., Abdel Aziz YM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University Ismailia 41522 Egypt., El-Sayed MAA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Mansoura University Mansoura 35516 Egypt magdaaziz1@yahoo.com.; Department of pharmaceutic organic chemistry, Faculty of Pharmacy, Mansoura National University Gamasa 7731168 Egypt., Elrayess R; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University Ismailia 41522 Egypt.; Pharmaceutical Organic Chemistry Department, College of Pharmacy, Al-Ayen Iraqi University, AUIQ An Nasiriyah 6400 Iraq. |
| Source: | RSC medicinal chemistry [RSC Med Chem] 2025 Dec 12. Date of Electronic Publication: 2025 Dec 12. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101759460 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2632-8682 (Electronic) Linking ISSN: 26328682 NLM ISO Abbreviation: RSC Med Chem |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41438166 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Design and synthesis of sorafenib-inspired benzofuran hybrids as VEGFR-2 inhibitors: antiproliferative evaluation, mechanistic insights, and docking studies in hepatocellular carcinoma. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Shehda+MS%22">Shehda MS</searchLink>; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Horus University-Egypt New Damietta 34518 Egypt mshehda@horus.edu.eg.<br /><searchLink fieldCode="AU" term="%22Almatary+AM%22">Almatary AM</searchLink>; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Horus University-Egypt New Damietta 34518 Egypt mshehda@horus.edu.eg.<br /><searchLink fieldCode="AU" term="%22Salem+MSH%22">Salem MSH</searchLink>; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University Ismailia 41522 Egypt.; SANKEN, The University of Osaka Mihogaoka Ibaraki Osaka 567-0047 Japan mohamedsalem43@sanken.osaka-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Aboutaleb+MH%22">Aboutaleb MH</searchLink>; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Horus University-Egypt New Damietta 34518 Egypt mshehda@horus.edu.eg.<br /><searchLink fieldCode="AU" term="%22Takizawa+S%22">Takizawa S</searchLink>; SANKEN, The University of Osaka Mihogaoka Ibaraki Osaka 567-0047 Japan mohamedsalem43@sanken.osaka-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Abdel+Aziz+YM%22">Abdel Aziz YM</searchLink>; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University Ismailia 41522 Egypt.<br /><searchLink fieldCode="AU" term="%22El-Sayed+MAA%22">El-Sayed MAA</searchLink>; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Mansoura University Mansoura 35516 Egypt magdaaziz1@yahoo.com.; Department of pharmaceutic organic chemistry, Faculty of Pharmacy, Mansoura National University Gamasa 7731168 Egypt.<br /><searchLink fieldCode="AU" term="%22Elrayess+R%22">Elrayess R</searchLink>; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University Ismailia 41522 Egypt.; Pharmaceutical Organic Chemistry Department, College of Pharmacy, Al-Ayen Iraqi University, AUIQ An Nasiriyah 6400 Iraq. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101759460%22">RSC medicinal chemistry</searchLink> [RSC Med Chem] 2025 Dec 12. <i>Date of Electronic Publication: </i>2025 Dec 12. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Royal+Society+of+Chemistry%22">Royal Society of Chemistry </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101759460 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2632-8682 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226328682%22">26328682 </searchLink><i>NLM ISO Abbreviation: </i>RSC Med Chem |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41438166 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1039/d5md00837a Languages: – Code: eng Text: English Titles: – TitleFull: Design and synthesis of sorafenib-inspired benzofuran hybrids as VEGFR-2 inhibitors: antiproliferative evaluation, mechanistic insights, and docking studies in hepatocellular carcinoma. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Shehda MS – PersonEntity: Name: NameFull: Almatary AM – PersonEntity: Name: NameFull: Salem MSH – PersonEntity: Name: NameFull: Aboutaleb MH – PersonEntity: Name: NameFull: Takizawa S – PersonEntity: Name: NameFull: Abdel Aziz YM – PersonEntity: Name: NameFull: El-Sayed MAA – PersonEntity: Name: NameFull: Elrayess R IsPartOfRelationships: – BibEntity: Dates: – D: 12 M: 12 Text: 2025 Dec 12 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2632-8682 Titles: – TitleFull: RSC medicinal chemistry Type: main |
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