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Multi-Omics and Single-Cell Dissection of Exostosin Glycosyltransferases (EXT1/EXT2) Reveals Divergent Oncogenic Roles and Therapeutic Vulnerabilities in Gliomas.

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Title: Multi-Omics and Single-Cell Dissection of Exostosin Glycosyltransferases (EXT1/EXT2) Reveals Divergent Oncogenic Roles and Therapeutic Vulnerabilities in Gliomas.
Authors: Chiang YC; Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.; Department of Surgery, Division of Neurosurgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan., Wang CY; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan., Palekkode N; PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Department of Biotechnology, Mother Teresa Women's University, Kodaikanal, Tamil Nadu, 624101, India., Yang SF; Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan., Chang KF; Medical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.; Division of Experimental Surgery Center, Department of Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei 11490, Taiwan., Ko CC; Department of Medical Imaging, Chi-Mei Medical Center, Tainan710402, Taiwan.; Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan.; School of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan., Chang CH; Medical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.; Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan., Lin HR; Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.; Nursing Department, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan., Wu CJ; Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.; College of Nursing, Kaohsiung Medical University, Kaohsiung 80708, Taiwan., Ho YC; School of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan., Lin CC; Department of Physical Therapy, I-Shou University, Kaohsiung 824005, Taiwan., Yuan CH; Medical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.; Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.; Department of Otolaryngology, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.; Department of Otolaryngology, National Defense Medical University, Taipei 11490, Taiwan., Kumar S; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Himachal Pradesh 173229, India., Solomon DD; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Yogananda School of AI Computers and Data Sciences, Shoolini University, Solan 173229, India., Ngadio JL; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Department of Bioinformatics, School of Life Sciences, Indonesia International Institute for Life Sciences, Jl. Pulomas Barat Kav 88, Jakarta Timur 13210, Indonesia., Wulandari FS; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan., Xuan DTM; Faculty of Pharmacy, Van Lang University, 69/68 Dang Thuy Tram Street, Binh Loi Trung Ward, Ho Chi Minh City, 70000, Vietnam., Hsieh CB; Division of General Surgery, Department of Surgery, Tri-Service General Hospital, Taipei 114202, Taiwan., Yen MC; Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan., Yeh IJ; Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan., Ko PC; Department of Neurosurgery, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, Taiwan., Shih CL; Clinical Research Center, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City 60002, Taiwan., Chan HB; Department of Neurosurgery, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, Taiwan., Lee YK; Medical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.; Division of Experimental Surgery Center, Department of Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei 11490, Taiwan.; Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.; School of Medicine, National Defense Medical University, Taipei 11490, Taiwan., Nguyen NUN; Center for Regenerative Medicine, University of South Florida Health Heart Institute, Tampa, Florida 33602, USA.; Division of Cardiology, Department of Internal Medicine, Morsani School of Medicine, University of South Florida, Tampa, Florida 33602, USA.
Source: Journal of Cancer [J Cancer] 2026 Jan 01; Vol. 17 (1), pp. 177-196. Date of Electronic Publication: 2026 Jan 01 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101535920 Publication Model: eCollection Cited Medium: Print ISSN: 1837-9664 (Print) Linking ISSN: 18379664 NLM ISO Abbreviation: J Cancer Subsets: PubMed not MEDLINE
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  Data: Multi-Omics and Single-Cell Dissection of Exostosin Glycosyltransferases (EXT1/EXT2) Reveals Divergent Oncogenic Roles and Therapeutic Vulnerabilities in Gliomas.
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  Data: <searchLink fieldCode="AU" term="%22Chiang+YC%22">Chiang YC</searchLink>; Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.; Department of Surgery, Division of Neurosurgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+CY%22">Wang CY</searchLink>; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.<br /><searchLink fieldCode="AU" term="%22Palekkode+N%22">Palekkode N</searchLink>; PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Department of Biotechnology, Mother Teresa Women's University, Kodaikanal, Tamil Nadu, 624101, India.<br /><searchLink fieldCode="AU" term="%22Yang+SF%22">Yang SF</searchLink>; Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+KF%22">Chang KF</searchLink>; Medical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.; Division of Experimental Surgery Center, Department of Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei 11490, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ko+CC%22">Ko CC</searchLink>; Department of Medical Imaging, Chi-Mei Medical Center, Tainan710402, Taiwan.; Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan.; School of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+CH%22">Chang CH</searchLink>; Medical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.; Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+HR%22">Lin HR</searchLink>; Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.; Nursing Department, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+CJ%22">Wu CJ</searchLink>; Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.; College of Nursing, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ho+YC%22">Ho YC</searchLink>; School of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+CC%22">Lin CC</searchLink>; Department of Physical Therapy, I-Shou University, Kaohsiung 824005, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yuan+CH%22">Yuan CH</searchLink>; Medical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.; Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.; Department of Otolaryngology, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.; Department of Otolaryngology, National Defense Medical University, Taipei 11490, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kumar+S%22">Kumar S</searchLink>; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Himachal Pradesh 173229, India.<br /><searchLink fieldCode="AU" term="%22Solomon+DD%22">Solomon DD</searchLink>; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Yogananda School of AI Computers and Data Sciences, Shoolini University, Solan 173229, India.<br /><searchLink fieldCode="AU" term="%22Ngadio+JL%22">Ngadio JL</searchLink>; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Department of Bioinformatics, School of Life Sciences, Indonesia International Institute for Life Sciences, Jl. Pulomas Barat Kav 88, Jakarta Timur 13210, Indonesia.<br /><searchLink fieldCode="AU" term="%22Wulandari+FS%22">Wulandari FS</searchLink>; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.<br /><searchLink fieldCode="AU" term="%22Xuan+DTM%22">Xuan DTM</searchLink>; Faculty of Pharmacy, Van Lang University, 69/68 Dang Thuy Tram Street, Binh Loi Trung Ward, Ho Chi Minh City, 70000, Vietnam.<br /><searchLink fieldCode="AU" term="%22Hsieh+CB%22">Hsieh CB</searchLink>; Division of General Surgery, Department of Surgery, Tri-Service General Hospital, Taipei 114202, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yen+MC%22">Yen MC</searchLink>; Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yeh+IJ%22">Yeh IJ</searchLink>; Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ko+PC%22">Ko PC</searchLink>; Department of Neurosurgery, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, Taiwan.<br /><searchLink fieldCode="AU" term="%22Shih+CL%22">Shih CL</searchLink>; Clinical Research Center, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City 60002, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chan+HB%22">Chan HB</searchLink>; Department of Neurosurgery, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+YK%22">Lee YK</searchLink>; Medical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.; Division of Experimental Surgery Center, Department of Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei 11490, Taiwan.; Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.; School of Medicine, National Defense Medical University, Taipei 11490, Taiwan.<br /><searchLink fieldCode="AU" term="%22Nguyen+NUN%22">Nguyen NUN</searchLink>; Center for Regenerative Medicine, University of South Florida Health Heart Institute, Tampa, Florida 33602, USA.; Division of Cardiology, Department of Internal Medicine, Morsani School of Medicine, University of South Florida, Tampa, Florida 33602, USA.
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  Data: <searchLink fieldCode="JN" term="%22101535920%22">Journal of Cancer</searchLink> [J Cancer] 2026 Jan 01; Vol. 17 (1), pp. 177-196. <i>Date of Electronic Publication: </i>2026 Jan 01 (<i>Print Publication: </i>2026).
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