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Multiomic Immune Profiling of Pediatric Transplant Recipients Identifies Cell States Associated with Vaccine Response.

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Title: Multiomic Immune Profiling of Pediatric Transplant Recipients Identifies Cell States Associated with Vaccine Response.
Authors: Wedel J; Transplant Research Program, Boston Children's Hospital, Boston, Massachusetts.; Division of Nephrology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.; Computational Health Informatics Program, Boston Children's Hospital, Boston, Massachusetts.; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts., Tang Y; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts., Alsairafi B; Transplant Research Program, Boston Children's Hospital, Boston, Massachusetts.; Division of Nephrology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts., Do V; Transplant Research Program, Boston Children's Hospital, Boston, Massachusetts.; Division of Nephrology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts., Maslyar M; Transplant Research Program, Boston Children's Hospital, Boston, Massachusetts.; Division of Nephrology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts., Fleming R; Division of Hematology and Oncology, Boston Children's Hospital, Boston, Massachusetts., Schwartz MA; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Division of Hematology and Oncology, Boston Children's Hospital, Boston, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Broad Institute, Cambridge, Massachusetts., Gerdemann U; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Division of Hematology and Oncology, Boston Children's Hospital, Boston, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Albanese A; Division of Hematology and Oncology, Boston Children's Hospital, Boston, Massachusetts., Mitsialis V; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts.; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts., Collen LV; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts., Nishitani M; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Division of Hematology and Oncology, Boston Children's Hospital, Boston, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Bresnahan M; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts., Saccocia G; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts., Bearup R; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts., Okoroafor I; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts., Siegel SJ; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Division of Hematology and Oncology, Boston Children's Hospital, Boston, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Wachter F; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Division of Hematology and Oncology, Boston Children's Hospital, Boston, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Waters K; Division of Hematology and Oncology, Boston Children's Hospital, Boston, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Weichert-Leahey N; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Division of Hematology and Oncology, Boston Children's Hospital, Boston, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Clarke NJ; Quest Diagnostics Nichols Institute, San Juan Capistrano, California., Mandl KD; Computational Health Informatics Program, Boston Children's Hospital, Boston, Massachusetts.; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts., Kean LS; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Division of Hematology and Oncology, Boston Children's Hospital, Boston, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Snapper SB; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts.; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts.; Program in Immunology, Harvard Medical School, Boston, Massachusetts., Briscoe DM; Transplant Research Program, Boston Children's Hospital, Boston, Massachusetts.; Division of Nephrology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts., Horwitz BH; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts.; Program in Immunology, Harvard Medical School, Boston, Massachusetts.; Division of Emergency Medicine, Boston Children's Hospital, Boston, Massachusetts.
Source: Clinical journal of the American Society of Nephrology : CJASN [Clin J Am Soc Nephrol] 2026 Apr 01; Vol. 21 (4), pp. 650-663. Date of Electronic Publication: 2025 Dec 24.
Publication Type: Journal Article
Journal Info: Publisher: Wolters Kluwer Health Country of Publication: United States NLM ID: 101271570 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1555-905X (Electronic) Linking ISSN: 15559041 NLM ISO Abbreviation: Clin J Am Soc Nephrol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Multiomic Immune Profiling of Pediatric Transplant Recipients Identifies Cell States Associated with Vaccine Response.
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  Data: <searchLink fieldCode="AU" term="%22Wedel+J%22">Wedel J</searchLink>; Transplant Research Program, Boston Children's Hospital, Boston, Massachusetts.; Division of Nephrology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.; Computational Health Informatics Program, Boston Children's Hospital, Boston, Massachusetts.; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Tang+Y%22">Tang Y</searchLink>; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Alsairafi+B%22">Alsairafi B</searchLink>; Transplant Research Program, Boston Children's Hospital, Boston, Massachusetts.; Division of Nephrology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Do+V%22">Do V</searchLink>; Transplant Research Program, Boston Children's Hospital, Boston, Massachusetts.; Division of Nephrology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Maslyar+M%22">Maslyar M</searchLink>; Transplant Research Program, Boston Children's Hospital, Boston, Massachusetts.; Division of Nephrology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Fleming+R%22">Fleming R</searchLink>; Division of Hematology and Oncology, Boston Children's Hospital, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Schwartz+MA%22">Schwartz MA</searchLink>; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Division of Hematology and Oncology, Boston Children's Hospital, Boston, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Broad Institute, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Gerdemann+U%22">Gerdemann U</searchLink>; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Division of Hematology and Oncology, Boston Children's Hospital, Boston, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Albanese+A%22">Albanese A</searchLink>; Division of Hematology and Oncology, Boston Children's Hospital, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Mitsialis+V%22">Mitsialis V</searchLink>; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts.; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Collen+LV%22">Collen LV</searchLink>; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Nishitani+M%22">Nishitani M</searchLink>; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Division of Hematology and Oncology, Boston Children's Hospital, Boston, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Bresnahan+M%22">Bresnahan M</searchLink>; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Saccocia+G%22">Saccocia G</searchLink>; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Bearup+R%22">Bearup R</searchLink>; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Okoroafor+I%22">Okoroafor I</searchLink>; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Siegel+SJ%22">Siegel SJ</searchLink>; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Division of Hematology and Oncology, Boston Children's Hospital, Boston, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Wachter+F%22">Wachter F</searchLink>; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Division of Hematology and Oncology, Boston Children's Hospital, Boston, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Waters+K%22">Waters K</searchLink>; Division of Hematology and Oncology, Boston Children's Hospital, Boston, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Weichert-Leahey+N%22">Weichert-Leahey N</searchLink>; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Division of Hematology and Oncology, Boston Children's Hospital, Boston, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Clarke+NJ%22">Clarke NJ</searchLink>; Quest Diagnostics Nichols Institute, San Juan Capistrano, California.<br /><searchLink fieldCode="AU" term="%22Mandl+KD%22">Mandl KD</searchLink>; Computational Health Informatics Program, Boston Children's Hospital, Boston, Massachusetts.; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Kean+LS%22">Kean LS</searchLink>; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Division of Hematology and Oncology, Boston Children's Hospital, Boston, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Snapper+SB%22">Snapper SB</searchLink>; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts.; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts.; Program in Immunology, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Briscoe+DM%22">Briscoe DM</searchLink>; Transplant Research Program, Boston Children's Hospital, Boston, Massachusetts.; Division of Nephrology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Horwitz+BH%22">Horwitz BH</searchLink>; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts.; Program in Immunology, Harvard Medical School, Boston, Massachusetts.; Division of Emergency Medicine, Boston Children's Hospital, Boston, Massachusetts.
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  Data: <searchLink fieldCode="JN" term="%22101271570%22">Clinical journal of the American Society of Nephrology : CJASN</searchLink> [Clin J Am Soc Nephrol] 2026 Apr 01; Vol. 21 (4), pp. 650-663. <i>Date of Electronic Publication: </i>2025 Dec 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wolters+Kluwer+Health%22">Wolters Kluwer Health </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101271570 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1555-905X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215559041%22">15559041 </searchLink><i>NLM ISO Abbreviation: </i>Clin J Am Soc Nephrol <i>Subsets: </i>MEDLINE
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