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Meta-analysis of genome-wide association studies of doxorubicin-induced arrhythmia identifies MMP16 and KCTD15 as risk loci.

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Title: Meta-analysis of genome-wide association studies of doxorubicin-induced arrhythmia identifies MMP16 and KCTD15 as risk loci.
Authors: Reddy JS; Quantitative Health Sciences, Mayo Clinic Florida, Jacksonville, FL, USA., Pereyra M; Cardiovascular Medicine, Mayo Clinic Arizona, Scottsdale, AZ, USA., Abbas MT; Cardiovascular Medicine, Mayo Clinic Arizona, Scottsdale, AZ, USA., Arsanjani R; Cardiovascular Medicine, Mayo Clinic Arizona, Scottsdale, AZ, USA., Prah IE; Cancer Biology, Mayo Clinic Florida, Jacksonville, FL, USA., Boddicker NJ; Division of Computational Biology, Mayo Clinic, Rochester, MN, USA., Cerhan JR; Division of Epidemiology, Mayo Clinic, Rochester, MN, USA., Larson MC; Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, MN, USA., Mwangi R; Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, MN, USA., Habermann TM; Division of Hematology, Mayo Clinic, Rochester, MN, USA., Villarraga HR; Department of Cardiovascular Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA., Vierkant RA; Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Luehrs TC; Division of Computational Biology, Mayo Clinic, Rochester, MN, USA.; Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Sicotte H; Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Egan JB; Center for Individualized Medicine, Mayo Clinic, Scottsdale, AZ, USA., Lazaridis KN; Center for Individualized Medicine, Mayo Clinic, Scottsdale, AZ, USA.; Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, MN, USA., Moossavi M; Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Xu X; Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Advani PP; Hematology and Oncology, Mayo Clinic Florida, Jacksonville, FL, USA., Ayoub C; Cardiovascular Medicine, Mayo Clinic Arizona, Scottsdale, AZ, USA., Norton N; Cancer Biology, Mayo Clinic Florida, Jacksonville, FL, USA.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Dec 18. Date of Electronic Publication: 2025 Dec 18.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Meta-analysis of genome-wide association studies of doxorubicin-induced arrhythmia identifies MMP16 and KCTD15 as risk loci.
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  Data: <searchLink fieldCode="AU" term="%22Reddy+JS%22">Reddy JS</searchLink>; Quantitative Health Sciences, Mayo Clinic Florida, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Pereyra+M%22">Pereyra M</searchLink>; Cardiovascular Medicine, Mayo Clinic Arizona, Scottsdale, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Abbas+MT%22">Abbas MT</searchLink>; Cardiovascular Medicine, Mayo Clinic Arizona, Scottsdale, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Arsanjani+R%22">Arsanjani R</searchLink>; Cardiovascular Medicine, Mayo Clinic Arizona, Scottsdale, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Prah+IE%22">Prah IE</searchLink>; Cancer Biology, Mayo Clinic Florida, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Boddicker+NJ%22">Boddicker NJ</searchLink>; Division of Computational Biology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Cerhan+JR%22">Cerhan JR</searchLink>; Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Larson+MC%22">Larson MC</searchLink>; Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Mwangi+R%22">Mwangi R</searchLink>; Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Habermann+TM%22">Habermann TM</searchLink>; Division of Hematology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Villarraga+HR%22">Villarraga HR</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Vierkant+RA%22">Vierkant RA</searchLink>; Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Luehrs+TC%22">Luehrs TC</searchLink>; Division of Computational Biology, Mayo Clinic, Rochester, MN, USA.; Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Sicotte+H%22">Sicotte H</searchLink>; Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Egan+JB%22">Egan JB</searchLink>; Center for Individualized Medicine, Mayo Clinic, Scottsdale, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Lazaridis+KN%22">Lazaridis KN</searchLink>; Center for Individualized Medicine, Mayo Clinic, Scottsdale, AZ, USA.; Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Moossavi+M%22">Moossavi M</searchLink>; Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Advani+PP%22">Advani PP</searchLink>; Hematology and Oncology, Mayo Clinic Florida, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Ayoub+C%22">Ayoub C</searchLink>; Cardiovascular Medicine, Mayo Clinic Arizona, Scottsdale, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Norton+N%22">Norton N</searchLink>; Cancer Biology, Mayo Clinic Florida, Jacksonville, FL, USA.
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  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101767986 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>NLM ISO Abbreviation: </i>medRxiv <i>Subsets: </i>PubMed not MEDLINE
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