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Mapping the Functional Landscape of KCNQ1 to Define Ion Channel Mechanisms and Arrhythmia Risk.

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Title: Mapping the Functional Landscape of KCNQ1 to Define Ion Channel Mechanisms and Arrhythmia Risk.
Authors: Harvey ML; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Osborn E; Vanderbilt Human Genetics Program, Vanderbilt University, Nashville, TN, USA., Lancaster MC; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Smith JE; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Shen Q; Mark Cowley Lidwill Research Program in Cardiac Electrophysiology, Victor Chang Cardiac Research Institute, Darlinghurst, Australia., Abe T; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Cai R; Stanford Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Department of Medicine, Stanford School of Medicine, Palo Alto, CA, USA., Muhammad A; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Kannankeril R; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Yang T; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Calandranis ME; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Blackwell DJ; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Dolder RE 3rd; Vanderbilt Human Genetics Program, Vanderbilt University, Nashville, TN, USA., Aldridge JL; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Fleming MR; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Blair MA; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Soria E; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., O'Sullivan JW; Stanford Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Department of Medicine, Stanford School of Medicine, Palo Alto, CA, USA., Davogustto G; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Kroncke BM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., MacRae CA; Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Knollmann BC; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Roth FP; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Parikh VN; Stanford Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Department of Medicine, Stanford School of Medicine, Palo Alto, CA, USA., Ashley EA; Stanford Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Department of Medicine, Stanford School of Medicine, Palo Alto, CA, USA., Vandenberg JI; Mark Cowley Lidwill Research Program in Cardiac Electrophysiology, Victor Chang Cardiac Research Institute, Darlinghurst, Australia.; School of Clinical Medicine, University of New South Wales, Sydney, Australia., Ng CA; Mark Cowley Lidwill Research Program in Cardiac Electrophysiology, Victor Chang Cardiac Research Institute, Darlinghurst, Australia.; School of Clinical Medicine, University of New South Wales, Sydney, Australia., Roden DM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA., Glazer AM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; School of Clinical Medicine, University of New South Wales, Sydney, Australia.; Lead contact.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Dec 16. Date of Electronic Publication: 2025 Dec 16.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
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Stanford Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Department of Medicine, Stanford School of Medicine, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Muhammad+A%22">Muhammad A</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Kannankeril+R%22">Kannankeril R</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Yang+T%22">Yang T</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Calandranis+ME%22">Calandranis ME</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Blackwell+DJ%22">Blackwell DJ</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Dolder+RE+3rd%22">Dolder RE 3rd</searchLink>; Vanderbilt Human Genetics Program, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Aldridge+JL%22">Aldridge JL</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Fleming+MR%22">Fleming MR</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Blair+MA%22">Blair MA</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Soria+E%22">Soria E</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22O'Sullivan+JW%22">O'Sullivan JW</searchLink>; Stanford Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Department of Medicine, Stanford School of Medicine, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Davogustto+G%22">Davogustto G</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Kroncke+BM%22">Kroncke BM</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22MacRae+CA%22">MacRae CA</searchLink>; Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Knollmann+BC%22">Knollmann BC</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Roth+FP%22">Roth FP</searchLink>; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Parikh+VN%22">Parikh VN</searchLink>; Stanford Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Department of Medicine, Stanford School of Medicine, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ashley+EA%22">Ashley EA</searchLink>; 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Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Glazer+AM%22">Glazer AM</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; School of Clinical Medicine, University of New South Wales, Sydney, Australia.; Lead contact.
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