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Discovery and in vivo evaluation of a fluorine-18 pro-drug tracer for imaging sphingosine-1-phosphate receptor 2 in the brain.

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Bibliographic Details
Title: Discovery and in vivo evaluation of a fluorine-18 pro-drug tracer for imaging sphingosine-1-phosphate receptor 2 in the brain.
Authors: Qiu L; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States., Zhou W; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States., Chen H; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States., Jiang H; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States., Lang J; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States., Xing Z; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States., Heady M; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States., Gropler RJ; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States., Guglielmetti C; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States., Perlmutter JS; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States; Neurology, Neuroscience, Physical Therapy and Occupational Therapy, Washington University School of Medicine, St. Louis, MO 63110, United States., Tu Z; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States. Electronic address: zhudetu@wustl.edu.
Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2026 Mar; Vol. 134, pp. 118536. Date of Electronic Publication: 2025 Dec 20.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1464-3391
DOI:10.1016/j.bmc.2025.118536