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Discovery and in vivo evaluation of a fluorine-18 pro-drug tracer for imaging sphingosine-1-phosphate receptor 2 in the brain.

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Title: Discovery and in vivo evaluation of a fluorine-18 pro-drug tracer for imaging sphingosine-1-phosphate receptor 2 in the brain.
Authors: Qiu L; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States., Zhou W; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States., Chen H; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States., Jiang H; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States., Lang J; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States., Xing Z; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States., Heady M; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States., Gropler RJ; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States., Guglielmetti C; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States., Perlmutter JS; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States; Neurology, Neuroscience, Physical Therapy and Occupational Therapy, Washington University School of Medicine, St. Louis, MO 63110, United States., Tu Z; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States. Electronic address: zhudetu@wustl.edu.
Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2026 Mar; Vol. 134, pp. 118536. Date of Electronic Publication: 2025 Dec 20.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery and in vivo evaluation of a fluorine-18 pro-drug tracer for imaging sphingosine-1-phosphate receptor 2 in the brain.
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  Data: <searchLink fieldCode="AU" term="%22Qiu+L%22">Qiu L</searchLink>; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States.<br /><searchLink fieldCode="AU" term="%22Zhou+W%22">Zhou W</searchLink>; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States.<br /><searchLink fieldCode="AU" term="%22Jiang+H%22">Jiang H</searchLink>; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States.<br /><searchLink fieldCode="AU" term="%22Lang+J%22">Lang J</searchLink>; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States.<br /><searchLink fieldCode="AU" term="%22Xing+Z%22">Xing Z</searchLink>; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States.<br /><searchLink fieldCode="AU" term="%22Heady+M%22">Heady M</searchLink>; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States.<br /><searchLink fieldCode="AU" term="%22Gropler+RJ%22">Gropler RJ</searchLink>; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States.<br /><searchLink fieldCode="AU" term="%22Guglielmetti+C%22">Guglielmetti C</searchLink>; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States.<br /><searchLink fieldCode="AU" term="%22Perlmutter+JS%22">Perlmutter JS</searchLink>; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States; Neurology, Neuroscience, Physical Therapy and Occupational Therapy, Washington University School of Medicine, St. Louis, MO 63110, United States.<br /><searchLink fieldCode="AU" term="%22Tu+Z%22">Tu Z</searchLink>; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States. Electronic address: zhudetu@wustl.edu.
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  Data: <searchLink fieldCode="JN" term="%229413298%22">Bioorganic & medicinal chemistry</searchLink> [Bioorg Med Chem] 2026 Mar; Vol. 134, pp. 118536. <i>Date of Electronic Publication: </i>2025 Dec 20.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9413298 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1464-3391 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209680896%22">09680896 </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.bmc.2025.118536
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        Text: English
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              Text: 2026 Mar
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