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Parabacteroides goldsteinii mitigates parkinsonism in LRRK2 mutant mice by reducing neuroinflammation through Gut-Brain axis.

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Title: Parabacteroides goldsteinii mitigates parkinsonism in LRRK2 mutant mice by reducing neuroinflammation through Gut-Brain axis.
Authors: Lin JD; Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan., Li H; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan., Hsu CL; Department of Medical Research, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan; Center for Computational and Systems Biology, National Taiwan University, Taipei, Taiwan., Lin TL; Department of Medical Biotechnology and Laboratory Science, and Emerging Viral Infections Research Center, Chang Gung University, Taoyuan, Taiwan., Chuang HL; National Applied Research Laboratories, National Laboratory Animal Center, Taipei, Taiwan., Lin HI; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan., Ho EP; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan., Chen YH; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan., Liu CW; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan., Chuang YT; Department of Medical Research, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan., Lung YY; Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan., Lien CJ; Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan., Chen HY; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan., Wu WK; Department of Medical Research, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan., Wu MS; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan., Lu CC; Department of Respiratory Therapy, Fu Jen Catholic University, New Taipei City, Taiwan., Lai HC; Department of Medical Biotechnology and Laboratory Science, and Emerging Viral Infections Research Center, Chang Gung University, Taoyuan, Taiwan. Electronic address: hsin.lai@revivebio.com.tw., Lin CH; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Biomedical Engineering, College of Medical Science and Technology, National Taiwan University, Taipei, Taiwan; Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: chlin@ntu.edu.tw.
Source: Journal of advanced research [J Adv Res] 2025 Dec 23. Date of Electronic Publication: 2025 Dec 23.
Publication Type: Journal Article
Journal Info: Publisher: Cairo University, production and hosting by Elsevier B. V Country of Publication: Egypt NLM ID: 101546952 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2090-1224 (Electronic) Linking ISSN: 20901224 NLM ISO Abbreviation: J Adv Res Subsets: MEDLINE
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  Data: Parabacteroides goldsteinii mitigates parkinsonism in LRRK2 mutant mice by reducing neuroinflammation through Gut-Brain axis.
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  Data: <searchLink fieldCode="AU" term="%22Lin+JD%22">Lin JD</searchLink>; Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsu+CL%22">Hsu CL</searchLink>; Department of Medical Research, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan; Center for Computational and Systems Biology, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+TL%22">Lin TL</searchLink>; Department of Medical Biotechnology and Laboratory Science, and Emerging Viral Infections Research Center, Chang Gung University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chuang+HL%22">Chuang HL</searchLink>; National Applied Research Laboratories, National Laboratory Animal Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+HI%22">Lin HI</searchLink>; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ho+EP%22">Ho EP</searchLink>; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YH%22">Chen YH</searchLink>; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+CW%22">Liu CW</searchLink>; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chuang+YT%22">Chuang YT</searchLink>; Department of Medical Research, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lung+YY%22">Lung YY</searchLink>; Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lien+CJ%22">Lien CJ</searchLink>; Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+HY%22">Chen HY</searchLink>; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+WK%22">Wu WK</searchLink>; Department of Medical Research, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+MS%22">Wu MS</searchLink>; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lu+CC%22">Lu CC</searchLink>; Department of Respiratory Therapy, Fu Jen Catholic University, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lai+HC%22">Lai HC</searchLink>; Department of Medical Biotechnology and Laboratory Science, and Emerging Viral Infections Research Center, Chang Gung University, Taoyuan, Taiwan. Electronic address: hsin.lai@revivebio.com.tw.<br /><searchLink fieldCode="AU" term="%22Lin+CH%22">Lin CH</searchLink>; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Biomedical Engineering, College of Medical Science and Technology, National Taiwan University, Taipei, Taiwan; Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: chlin@ntu.edu.tw.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cairo+University%2C+production+and+hosting+by+Elsevier+B%2E+V%22">Cairo University, production and hosting by Elsevier B. V </searchLink><i>Country of Publication: </i>Egypt <i>NLM ID: </i>101546952 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2090-1224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220901224%22">20901224 </searchLink><i>NLM ISO Abbreviation: </i>J Adv Res <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jare.2025.12.028
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        Text: English
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      – TitleFull: Parabacteroides goldsteinii mitigates parkinsonism in LRRK2 mutant mice by reducing neuroinflammation through Gut-Brain axis.
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              Text: 2025 Dec 23
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