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Abnormal upregulation of SPP1 promotes fibrotic scar after peripheral nerve repair (FS-PNR) by driving M2 macrophage polarization.

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Title: Abnormal upregulation of SPP1 promotes fibrotic scar after peripheral nerve repair (FS-PNR) by driving M2 macrophage polarization.
Authors: Fan J; Department of Microsurgery, Trauma and Hand Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 51080, China., Li Z; Department of Microsurgery, Trauma and Hand Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 51080, China., Zhang N; Department of Medical Ultrasonics, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangzhou 51080, China., Wang S; Department of Microsurgery, Trauma and Hand Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 51080, China., Zheng C; Department of Microsurgery, Trauma and Hand Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 51080, China; Guangdong Province Engineering Laboratory for Soft Tissue Biofabrication, Sun-Yat-sen University, Guangzhou 510080, China; Guangdong Provincial Key Laboratory for Orthopedics and Traumatology, Guangzhou 510080, China., Zhu Q; Department of Microsurgery, Trauma and Hand Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 51080, China; Guangdong Province Engineering Laboratory for Soft Tissue Biofabrication, Sun-Yat-sen University, Guangzhou 510080, China; Guangdong Provincial Key Laboratory for Orthopedics and Traumatology, Guangzhou 510080, China., Wang H; Department of Microsurgery, Trauma and Hand Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 51080, China; Guangdong Province Engineering Laboratory for Soft Tissue Biofabrication, Sun-Yat-sen University, Guangzhou 510080, China; Guangdong Provincial Key Laboratory for Orthopedics and Traumatology, Guangzhou 510080, China., Qi J; Department of Microsurgery, Trauma and Hand Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 51080, China; Guangdong Province Engineering Laboratory for Soft Tissue Biofabrication, Sun-Yat-sen University, Guangzhou 510080, China; Guangdong Provincial Key Laboratory for Orthopedics and Traumatology, Guangzhou 510080, China. Electronic address: qijian@mail.sysu.edu.cn., Yan L; Department of Microsurgery, Trauma and Hand Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 51080, China; Guangdong Province Engineering Laboratory for Soft Tissue Biofabrication, Sun-Yat-sen University, Guangzhou 510080, China; Guangdong Provincial Key Laboratory for Orthopedics and Traumatology, Guangzhou 510080, China. Electronic address: yanlw5@mail.sysu.edu.cn.
Source: Experimental neurology [Exp Neurol] 2026 Apr; Vol. 398, pp. 115612. Date of Electronic Publication: 2025 Dec 23.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2430 (Electronic) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Abnormal upregulation of SPP1 promotes fibrotic scar after peripheral nerve repair (FS-PNR) by driving M2 macrophage polarization.
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  Data: <searchLink fieldCode="AU" term="%22Fan+J%22">Fan J</searchLink>; Department of Microsurgery, Trauma and Hand Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 51080, China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Microsurgery, Trauma and Hand Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 51080, China.<br /><searchLink fieldCode="AU" term="%22Zhang+N%22">Zhang N</searchLink>; Department of Medical Ultrasonics, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangzhou 51080, China.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Department of Microsurgery, Trauma and Hand Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 51080, China.<br /><searchLink fieldCode="AU" term="%22Zheng+C%22">Zheng C</searchLink>; Department of Microsurgery, Trauma and Hand Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 51080, China; Guangdong Province Engineering Laboratory for Soft Tissue Biofabrication, Sun-Yat-sen University, Guangzhou 510080, China; Guangdong Provincial Key Laboratory for Orthopedics and Traumatology, Guangzhou 510080, China.<br /><searchLink fieldCode="AU" term="%22Zhu+Q%22">Zhu Q</searchLink>; Department of Microsurgery, Trauma and Hand Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 51080, China; Guangdong Province Engineering Laboratory for Soft Tissue Biofabrication, Sun-Yat-sen University, Guangzhou 510080, China; Guangdong Provincial Key Laboratory for Orthopedics and Traumatology, Guangzhou 510080, China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Microsurgery, Trauma and Hand Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 51080, China; Guangdong Province Engineering Laboratory for Soft Tissue Biofabrication, Sun-Yat-sen University, Guangzhou 510080, China; Guangdong Provincial Key Laboratory for Orthopedics and Traumatology, Guangzhou 510080, China.<br /><searchLink fieldCode="AU" term="%22Qi+J%22">Qi J</searchLink>; Department of Microsurgery, Trauma and Hand Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 51080, China; Guangdong Province Engineering Laboratory for Soft Tissue Biofabrication, Sun-Yat-sen University, Guangzhou 510080, China; Guangdong Provincial Key Laboratory for Orthopedics and Traumatology, Guangzhou 510080, China. Electronic address: qijian@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Yan+L%22">Yan L</searchLink>; Department of Microsurgery, Trauma and Hand Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 51080, China; Guangdong Province Engineering Laboratory for Soft Tissue Biofabrication, Sun-Yat-sen University, Guangzhou 510080, China; Guangdong Provincial Key Laboratory for Orthopedics and Traumatology, Guangzhou 510080, China. Electronic address: yanlw5@mail.sysu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%220370712%22">Experimental neurology</searchLink> [Exp Neurol] 2026 Apr; Vol. 398, pp. 115612. <i>Date of Electronic Publication: </i>2025 Dec 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Academic+Press%22">Academic Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0370712 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1090-2430 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200144886%22">00144886 </searchLink><i>NLM ISO Abbreviation: </i>Exp Neurol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.expneurol.2025.115612
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        Text: English
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              Text: 2026 Apr
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              Y: 2026
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