PAK1 inhibitor NVS-PAK1-1 preserves dendritic spines in amyloid/tau exposed neurons and 5xFAD mice.
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| Title: | PAK1 inhibitor NVS-PAK1-1 preserves dendritic spines in amyloid/tau exposed neurons and 5xFAD mice. |
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| Authors: | Yang T; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Huhe H; Department of Medicine-Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Williams SP; Department of Medicine-Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Kaur S; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Ay YA; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Davis-Gilbert ZW; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Cary GA; The Jackson Laboratory, Bar Harbor, Maine, USA.; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA., Paisie C; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA., Butler RR 3rd; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Wiley J; Sage Bionetworks, Seattle, Washington, USA., Betarbet R; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.; Department of Neurology, Emory University, Atlanta, Georgia, USA., Fu H; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.; Department of Pharmacology and Chemical Biology, Emory University, Atlanta, Georgia, USA., Duong D; Emory Integrated Proteomics Core (EIPC), Emory University, Atlanta, Georgia, USA., Seyfried NT; Emory Integrated Proteomics Core (EIPC), Emory University, Atlanta, Georgia, USA.; Department of Department of Biochemistry, Emory University, Atlanta, Georgia, USA., Leal K; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.; Sage Bionetworks, Seattle, Washington, USA., Carter GW; The Jackson Laboratory, Bar Harbor, Maine, USA.; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA., Edwards A; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.; Department of Medical Genetics and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Levey AI; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.; Department of Neurology, Emory University, Atlanta, Georgia, USA., Capener JL; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Drewry DH; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Hossain MA; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Oh HJ; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Axtman AD; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA., Sukoff Rizzo SJ; Department of Medicine-Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Longo FM; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.; Wu Tsai Neuroscience Institute, Stanford University, Stanford, California, USA. |
| Corporate Authors: | Emory‐Sage‐SGC‐Jax TREAT‐AD Center; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA. |
| Source: | Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Dec; Vol. 21 (12), pp. e71033. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1552-5279 |
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| DOI: | 10.1002/alz.71033 |
