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A subcutaneous implant that releases islatravir provides long-lasting protection against vaginal SHIV infection in macaques.

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Title: A subcutaneous implant that releases islatravir provides long-lasting protection against vaginal SHIV infection in macaques.
Authors: Daly MB; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA., Kim D; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA., Krovi A; RTI International, Durham, NC 27709, USA., Li L; RTI International, Durham, NC 27709, USA., Norton CA; RTI International, Durham, NC 27709, USA., Gatto GJ; RTI International, Durham, NC 27709, USA., Khalil G; Quantitative Sciences Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA., Brake M; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA., Wier R; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA., Mitchell J; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA., Johnson R; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA., Dinh C; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA., Edwards TE; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA., Haaland R; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA., Lipscomb J; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA., Cottrell ML; University of North Carolina Chapel Hill, Department of Pharmacotherapy and Experimental Therapeutics, NC, USA., Heneine W; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA., García-Lerma JG; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA., Johnson LM; RTI International, Durham, NC 27709, USA. Electronic address: leahjohnson@rti.org., Dobard CW; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: gok5@cdc.gov.
Source: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2026 Feb 10; Vol. 390, pp. 114575. Date of Electronic Publication: 2025 Dec 25.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: A subcutaneous implant that releases islatravir provides long-lasting protection against vaginal SHIV infection in macaques.
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  Data: <searchLink fieldCode="AU" term="%22Daly+MB%22">Daly MB</searchLink>; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+D%22">Kim D</searchLink>; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Krovi+A%22">Krovi A</searchLink>; RTI International, Durham, NC 27709, USA.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; RTI International, Durham, NC 27709, USA.<br /><searchLink fieldCode="AU" term="%22Norton+CA%22">Norton CA</searchLink>; RTI International, Durham, NC 27709, USA.<br /><searchLink fieldCode="AU" term="%22Gatto+GJ%22">Gatto GJ</searchLink>; RTI International, Durham, NC 27709, USA.<br /><searchLink fieldCode="AU" term="%22Khalil+G%22">Khalil G</searchLink>; Quantitative Sciences Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Brake+M%22">Brake M</searchLink>; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Wier+R%22">Wier R</searchLink>; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Mitchell+J%22">Mitchell J</searchLink>; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+R%22">Johnson R</searchLink>; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Dinh+C%22">Dinh C</searchLink>; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Edwards+TE%22">Edwards TE</searchLink>; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Haaland+R%22">Haaland R</searchLink>; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Lipscomb+J%22">Lipscomb J</searchLink>; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Cottrell+ML%22">Cottrell ML</searchLink>; University of North Carolina Chapel Hill, Department of Pharmacotherapy and Experimental Therapeutics, NC, USA.<br /><searchLink fieldCode="AU" term="%22Heneine+W%22">Heneine W</searchLink>; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22García-Lerma+JG%22">García-Lerma JG</searchLink>; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+LM%22">Johnson LM</searchLink>; RTI International, Durham, NC 27709, USA. Electronic address: leahjohnson@rti.org.<br /><searchLink fieldCode="AU" term="%22Dobard+CW%22">Dobard CW</searchLink>; Laboratory Branch, Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: gok5@cdc.gov.
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  Data: <searchLink fieldCode="JN" term="%228607908%22">Journal of controlled release : official journal of the Controlled Release Society</searchLink> [J Control Release] 2026 Feb 10; Vol. 390, pp. 114575. <i>Date of Electronic Publication: </i>2025 Dec 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Publishers%22">Elsevier Science Publishers </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8607908 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-4995 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201683659%22">01683659 </searchLink><i>NLM ISO Abbreviation: </i>J Control Release <i>Subsets: </i>MEDLINE
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        Text: English
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