4-Aminopyridine induced hyperpolarizing oscillations in pediatric human epileptic tissue are network-driven potassium currents that are abolished by activation of KCNQ2-5 (Kv7.2-Kv7.5) channels.
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| Title: | 4-Aminopyridine induced hyperpolarizing oscillations in pediatric human epileptic tissue are network-driven potassium currents that are abolished by activation of KCNQ2-5 (Kv7.2-Kv7.5) channels. |
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| Authors: | Kushner JK; Department of Neurosurgery, School of Medicine, University of Colorado | Anschutz Medical Campus, Aurora, CO 80045, USA; Neuroscience Graduate Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA; Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA; Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA. Electronic address: Keenan.Kushner@cuanschutz.edu., Hoffman PB; Department of Neurosurgery, School of Medicine, University of Colorado | Anschutz Medical Campus, Aurora, CO 80045, USA; Neuroscience Graduate Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Brzezinski CR; Department of Neurosurgery, School of Medicine, University of Colorado | Anschutz Medical Campus, Aurora, CO 80045, USA., O'Neill BR; Department of Neurosurgery, School of Medicine, University of Colorado | Anschutz Medical Campus, Aurora, CO 80045, USA; Division of Pediatric Neurosurgery, Children's Hospital Colorado, Aurora, CO 80045, USA., Hankinson TC; Department of Neurosurgery, School of Medicine, University of Colorado | Anschutz Medical Campus, Aurora, CO 80045, USA; Division of Pediatric Neurosurgery, Children's Hospital Colorado, Aurora, CO 80045, USA., Wilkinson CC; Department of Neurosurgery, School of Medicine, University of Colorado | Anschutz Medical Campus, Aurora, CO 80045, USA; Division of Pediatric Neurosurgery, Children's Hospital Colorado, Aurora, CO 80045, USA., Handler MH; Department of Neurosurgery, School of Medicine, University of Colorado | Anschutz Medical Campus, Aurora, CO 80045, USA; Division of Pediatric Neurosurgery, Children's Hospital Colorado, Aurora, CO 80045, USA., Hoeffer CA; Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA; Linda Crnic Institute, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Alexander AL; Department of Neurosurgery, School of Medicine, University of Colorado | Anschutz Medical Campus, Aurora, CO 80045, USA; Division of Pediatric Neurosurgery, Children's Hospital Colorado, Aurora, CO 80045, USA. Electronic address: Allyson.Alexander@childrenscolorado.org. |
| Source: | Neurobiology of disease [Neurobiol Dis] 2026 Jan; Vol. 218, pp. 107252. Date of Electronic Publication: 2025 Dec 26. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41456614 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: 4-Aminopyridine induced hyperpolarizing oscillations in pediatric human epileptic tissue are network-driven potassium currents that are abolished by activation of KCNQ2-5 (Kv7.2-Kv7.5) channels. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Kushner+JK%22">Kushner JK</searchLink>; Department of Neurosurgery, School of Medicine, University of Colorado | Anschutz Medical Campus, Aurora, CO 80045, USA; Neuroscience Graduate Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA; Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA; Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA. Electronic address: Keenan.Kushner@cuanschutz.edu.<br /><searchLink fieldCode="AU" term="%22Hoffman+PB%22">Hoffman PB</searchLink>; Department of Neurosurgery, School of Medicine, University of Colorado | Anschutz Medical Campus, Aurora, CO 80045, USA; Neuroscience Graduate Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Brzezinski+CR%22">Brzezinski CR</searchLink>; Department of Neurosurgery, School of Medicine, University of Colorado | Anschutz Medical Campus, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22O'Neill+BR%22">O'Neill BR</searchLink>; Department of Neurosurgery, School of Medicine, University of Colorado | Anschutz Medical Campus, Aurora, CO 80045, USA; Division of Pediatric Neurosurgery, Children's Hospital Colorado, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Hankinson+TC%22">Hankinson TC</searchLink>; Department of Neurosurgery, School of Medicine, University of Colorado | Anschutz Medical Campus, Aurora, CO 80045, USA; Division of Pediatric Neurosurgery, Children's Hospital Colorado, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Wilkinson+CC%22">Wilkinson CC</searchLink>; Department of Neurosurgery, School of Medicine, University of Colorado | Anschutz Medical Campus, Aurora, CO 80045, USA; Division of Pediatric Neurosurgery, Children's Hospital Colorado, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Handler+MH%22">Handler MH</searchLink>; Department of Neurosurgery, School of Medicine, University of Colorado | Anschutz Medical Campus, Aurora, CO 80045, USA; Division of Pediatric Neurosurgery, Children's Hospital Colorado, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Hoeffer+CA%22">Hoeffer CA</searchLink>; Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA; Linda Crnic Institute, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Alexander+AL%22">Alexander AL</searchLink>; Department of Neurosurgery, School of Medicine, University of Colorado | Anschutz Medical Campus, Aurora, CO 80045, USA; Division of Pediatric Neurosurgery, Children's Hospital Colorado, Aurora, CO 80045, USA. Electronic address: Allyson.Alexander@childrenscolorado.org. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229500169%22">Neurobiology of disease</searchLink> [Neurobiol Dis] 2026 Jan; Vol. 218, pp. 107252. <i>Date of Electronic Publication: </i>2025 Dec 26. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, N.I.H., Extramural – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Academic+Press%22">Academic Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9500169 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1095-953X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209699961%22">09699961 </searchLink><i>NLM ISO Abbreviation: </i>Neurobiol Dis <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41456614 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.nbd.2025.107252 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 107252 Titles: – TitleFull: 4-Aminopyridine induced hyperpolarizing oscillations in pediatric human epileptic tissue are network-driven potassium currents that are abolished by activation of KCNQ2-5 (Kv7.2-Kv7.5) channels. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kushner JK – PersonEntity: Name: NameFull: Hoffman PB – PersonEntity: Name: NameFull: Brzezinski CR – PersonEntity: Name: NameFull: O'Neill BR – PersonEntity: Name: NameFull: Hankinson TC – PersonEntity: Name: NameFull: Wilkinson CC – PersonEntity: Name: NameFull: Handler MH – PersonEntity: Name: NameFull: Hoeffer CA – PersonEntity: Name: NameFull: Alexander AL IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: 2026 Jan Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1095-953X Numbering: – Type: volume Value: 218 Titles: – TitleFull: Neurobiology of disease Type: main |
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