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A preclinical randomised controlled dose optimization of megadose sodium ascorbate for reversal of gram-negative sepsis-induced cardiovascular, brain and kidney dysfunction.

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Title: A preclinical randomised controlled dose optimization of megadose sodium ascorbate for reversal of gram-negative sepsis-induced cardiovascular, brain and kidney dysfunction.
Authors: Ow CPC; Translational Cardiovascular and Renal Research Group and Preclinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, 3052, Melbourne, VIC, Australia., Peiris RM; Translational Cardiovascular and Renal Research Group and Preclinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, 3052, Melbourne, VIC, Australia., Trask-Marino A; Translational Cardiovascular and Renal Research Group and Preclinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, 3052, Melbourne, VIC, Australia., Hood SG; Translational Cardiovascular and Renal Research Group and Preclinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, 3052, Melbourne, VIC, Australia., Betrie AH; Translational Cardiovascular and Renal Research Group and Preclinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, 3052, Melbourne, VIC, Australia.; Translational Neurodegeneration Laboratory, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia., Lane DJR; Translational Cardiovascular and Renal Research Group and Preclinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, 3052, Melbourne, VIC, Australia.; Translational Neurodegeneration Laboratory, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia., Bellomo R, Plummer MP; Department of Intensive Care, Royal Adelaide Hospital, Adelaide, Australia.; Department of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia., May CN; Translational Cardiovascular and Renal Research Group and Preclinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, 3052, Melbourne, VIC, Australia.; Department of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia., Lankadeva YR; Translational Cardiovascular and Renal Research Group and Preclinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, 3052, Melbourne, VIC, Australia. yugeesh.lankadeva@florey.edu.au.; Department of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia. yugeesh.lankadeva@florey.edu.au.
Source: Critical care (London, England) [Crit Care] 2025 Dec 28; Vol. 30 (1), pp. 6. Date of Electronic Publication: 2025 Dec 28.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 9801902 Publication Model: Electronic Cited Medium: Internet ISSN: 1466-609X (Electronic) Linking ISSN: 13648535 NLM ISO Abbreviation: Crit Care Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A preclinical randomised controlled dose optimization of megadose sodium ascorbate for reversal of gram-negative sepsis-induced cardiovascular, brain and kidney dysfunction.
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  Data: <searchLink fieldCode="AU" term="%22Ow+CPC%22">Ow CPC</searchLink>; Translational Cardiovascular and Renal Research Group and Preclinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, 3052, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Peiris+RM%22">Peiris RM</searchLink>; Translational Cardiovascular and Renal Research Group and Preclinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, 3052, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Trask-Marino+A%22">Trask-Marino A</searchLink>; Translational Cardiovascular and Renal Research Group and Preclinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, 3052, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Hood+SG%22">Hood SG</searchLink>; Translational Cardiovascular and Renal Research Group and Preclinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, 3052, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Betrie+AH%22">Betrie AH</searchLink>; Translational Cardiovascular and Renal Research Group and Preclinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, 3052, Melbourne, VIC, Australia.; Translational Neurodegeneration Laboratory, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Lane+DJR%22">Lane DJR</searchLink>; Translational Cardiovascular and Renal Research Group and Preclinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, 3052, Melbourne, VIC, Australia.; Translational Neurodegeneration Laboratory, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Bellomo+R%22">Bellomo R</searchLink><br /><searchLink fieldCode="AU" term="%22Plummer+MP%22">Plummer MP</searchLink>; Department of Intensive Care, Royal Adelaide Hospital, Adelaide, Australia.; Department of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22May+CN%22">May CN</searchLink>; Translational Cardiovascular and Renal Research Group and Preclinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, 3052, Melbourne, VIC, Australia.; Department of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Lankadeva+YR%22">Lankadeva YR</searchLink>; Translational Cardiovascular and Renal Research Group and Preclinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, 3052, Melbourne, VIC, Australia. yugeesh.lankadeva@florey.edu.au.; Department of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia. yugeesh.lankadeva@florey.edu.au.
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              Text: 2025 Dec 28
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