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PCMT1 generates the C-terminal cyclic imide degron on CRBN substrates.

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Title: PCMT1 generates the C-terminal cyclic imide degron on CRBN substrates.
Authors: Zhao Z; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Xu W; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Feng EY; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Cao S; Department of Pharmacology and Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Hermoso-López A; Department of Biochemistry and Molecular Biology, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) and Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, Madrid, Spain., Peña-Vega P; Department of Biochemistry and Molecular Biology, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) and Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, Madrid, Spain., Lloyd HC; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Porter AKD; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Guzmán M; Department of Biochemistry and Molecular Biology, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) and Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Zheng N; Department of Pharmacology and Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Woo CM; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. cwoo@chemistry.harvard.edu.; Affiliate Member, Broad Institute, Cambridge, MA, USA. cwoo@chemistry.harvard.edu.
Source: Nature chemical biology [Nat Chem Biol] 2026 May; Vol. 22 (5), pp. 802-812. Date of Electronic Publication: 2025 Dec 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
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  Data: PCMT1 generates the C-terminal cyclic imide degron on CRBN substrates.
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  Data: <searchLink fieldCode="AU" term="%22Zhao+Z%22">Zhao Z</searchLink>; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Xu+W%22">Xu W</searchLink>; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Feng+EY%22">Feng EY</searchLink>; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cao+S%22">Cao S</searchLink>; Department of Pharmacology and Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Hermoso-López+A%22">Hermoso-López A</searchLink>; Department of Biochemistry and Molecular Biology, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) and Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Peña-Vega+P%22">Peña-Vega P</searchLink>; Department of Biochemistry and Molecular Biology, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) and Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Lloyd+HC%22">Lloyd HC</searchLink>; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Porter+AKD%22">Porter AKD</searchLink>; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Guzmán+M%22">Guzmán M</searchLink>; Department of Biochemistry and Molecular Biology, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) and Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Zheng+N%22">Zheng N</searchLink>; Department of Pharmacology and Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Woo+CM%22">Woo CM</searchLink>; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. cwoo@chemistry.harvard.edu.; Affiliate Member, Broad Institute, Cambridge, MA, USA. cwoo@chemistry.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%22101231976%22">Nature chemical biology</searchLink> [Nat Chem Biol] 2026 May; Vol. 22 (5), pp. 802-812. <i>Date of Electronic Publication: </i>2025 Dec 29.
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              Text: 2026 May
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