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Microglial Activation in Nociplastic Pain: From Preclinical Models to PET Neuroimaging and Implications for Targeted Therapeutic Strategies.

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Title: Microglial Activation in Nociplastic Pain: From Preclinical Models to PET Neuroimaging and Implications for Targeted Therapeutic Strategies.
Authors: Coluzzi F; Department of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome, 00189 Rome, Italy.; Unit Anesthesia, Intensive Care and Pain Therapy, Sant'Andrea University Hospital, 00189 Rome, Italy., Zeboudj L; Wolfson Sensory, Pain and Regeneration Centre, King's College London, Guy's Campus, London Bridge, London SE1 1UL, UK., Scerpa MS; Unit Anesthesia, Intensive Care and Pain Therapy, Sant'Andrea University Hospital, 00189 Rome, Italy., Giorgio A; Department of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome, 00189 Rome, Italy., De Blasi RA; Department of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome, 00189 Rome, Italy.; Unit Anesthesia, Intensive Care and Pain Therapy, Sant'Andrea University Hospital, 00189 Rome, Italy., Malcangio M; Wolfson Sensory, Pain and Regeneration Centre, King's College London, Guy's Campus, London Bridge, London SE1 1UL, UK., Rocco M; Department of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome, 00189 Rome, Italy.; Unit Anesthesia, Intensive Care and Pain Therapy, Sant'Andrea University Hospital, 00189 Rome, Italy.
Source: International journal of molecular sciences [Int J Mol Sci] 2025 Dec 09; Vol. 26 (24). Date of Electronic Publication: 2025 Dec 09.
Publication Type: Journal Article; Review
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1422-0067
DOI:10.3390/ijms262411861