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Interpretable multimodal deep learning improves postoperative risk stratification in intrahepatic cholangiocarcinoma in multicentre cohorts.

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Title: Interpretable multimodal deep learning improves postoperative risk stratification in intrahepatic cholangiocarcinoma in multicentre cohorts.
Authors: Wan M; Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, & Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Hangzhou, China., Ding Y; Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, & Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Hangzhou, China., Wang Y; Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Jia Y; Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, & Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Hangzhou, China., Wu S; The First Clinical School of Medicine, Zhengzhou University, Zhengzhou, China., Qu W; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Xu Y; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Fu W; Department of Hepatobiliary Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China., Timko MP; Departments of Biology and Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Wan L; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA., Ying L; Department of Medicine, Monash University, Clayton, VIC, Australia., Ye C; Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, & Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Hangzhou, China., Chen R; Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, & Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Hangzhou, China., Li Q; Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, & Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Hangzhou, China., He Y; Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, & Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Hangzhou, China., Xu K; Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, & Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Hangzhou, China., Xu N; Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, & Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Hangzhou, China., Chen J; Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China. chenjinzhang@smu.edu.cn., Zheng D; Department of Oncology, Shunde Hospital, Southern Medical University, Shunde, China. zhengdayong@hotmail.com., Shen Y; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. yifeishen@zju.edu.cn.; Department of Bioinformatics and Computational Biology, MD Anderson Cancer Center, Houston, TX, USA. yifeishen@zju.edu.cn., Ruan J; Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, & Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Hangzhou, China. software233@zju.edu.cn.
Source: NPJ digital medicine [NPJ Digit Med] 2025 Dec 29; Vol. 9 (1), pp. 95. Date of Electronic Publication: 2025 Dec 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101731738 Publication Model: Electronic Cited Medium: Internet ISSN: 2398-6352 (Electronic) Linking ISSN: 23986352 NLM ISO Abbreviation: NPJ Digit Med Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Wan+M%22">Wan M</searchLink>; Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, & Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Ding+Y%22">Ding Y</searchLink>; Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, & Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Jia+Y%22">Jia Y</searchLink>; Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, & Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wu+S%22">Wu S</searchLink>; The First Clinical School of Medicine, Zhengzhou University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Qu+W%22">Qu W</searchLink>; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Fu+W%22">Fu W</searchLink>; Department of Hepatobiliary Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.<br /><searchLink fieldCode="AU" term="%22Timko+MP%22">Timko MP</searchLink>; Departments of Biology and Public Health Sciences, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Wan+L%22">Wan L</searchLink>; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ying+L%22">Ying L</searchLink>; Department of Medicine, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Ye+C%22">Ye C</searchLink>; Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, & Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+R%22">Chen R</searchLink>; Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, & Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, & Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22He+Y%22">He Y</searchLink>; Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, & Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xu+K%22">Xu K</searchLink>; Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, & Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xu+N%22">Xu N</searchLink>; Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, & Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China. chenjinzhang@smu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zheng+D%22">Zheng D</searchLink>; Department of Oncology, Shunde Hospital, Southern Medical University, Shunde, China. zhengdayong@hotmail.com.<br /><searchLink fieldCode="AU" term="%22Shen+Y%22">Shen Y</searchLink>; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. yifeishen@zju.edu.cn.; Department of Bioinformatics and Computational Biology, MD Anderson Cancer Center, Houston, TX, USA. yifeishen@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Ruan+J%22">Ruan J</searchLink>; Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, & Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Hangzhou, China. software233@zju.edu.cn.
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