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Mycophenolate Mofetil Treatment Reduces the Risk of Treatment Escalation Due to Vascular Complications in Limited Cutaneous Systemic Sclerosis: Emulation of a Target Trial From the Italian Rheumatology Society SPRING Registry.

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Title: Mycophenolate Mofetil Treatment Reduces the Risk of Treatment Escalation Due to Vascular Complications in Limited Cutaneous Systemic Sclerosis: Emulation of a Target Trial From the Italian Rheumatology Society SPRING Registry.
Authors: De Lorenzis E; Division of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Rheumatology, Faculty of Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy., Natalello G; Division of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Rheumatology, Faculty of Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy., De Angelis R; Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy., Verardi L; Division of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Rheumatology, Faculty of Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy., Giuggioli D; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy., Bajocchi G; Rheumatology Unit, Azienda USL IRCCS di Reggio Emilia, Reggio Emilia, Italy., Dagna L; Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy., Bellando-Randone S; Division of Rheumatology, Scleroderma Unit, Department of Experimental and Clinical Medicine, AOU Careggi, University of Florence, Florence, Italy., Zanframundo G; Department of Internal Medicine and Therapeutics, Università di Pavia, Pavia, Italy.; Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Foti R; Rheumatology Unit, AOU Policlinico S. Marco, Catania, Italy., Cacciapaglia F; Rheumatology Service 'F. Miulli' General Hospital Acquaviva delle Fonti - Department of Medicine and Surgery, LUM University 'Giuseppe De Gennaro' Casamassima, Bari, Italy., Cuomo G; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Caserta, Italy., Ariani A; Department of Medicine, Internal Medicine and Rheumatology, Azienda Ospedaliero Universitaria di Parma, Parma, Italy., Rosato E; Department of Translational and Precision Medicine, Sapienza University of Rome, Roma, Italy., Lepri G; Division of Rheumatology, Scleroderma Unit, Department of Experimental and Clinical Medicine, AOU Careggi, University of Florence, Florence, Italy., Girelli F; Rheumatology Unit, AUSL Romagna, Ospedale G.B. Morgagni, Forlì, Italy., Riccieri V; Department of Rheumatology, Sapienza University of Rome, Rome, Italy., Zanatta E; Department of Rheumatology, University of Padua, Padua, Italy.; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy., Cavazzana I; Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Ingegnoli F; Rheumatology Clinic, ASST Pini CTO, Department of Clinical Sciences & Community Health, Università degli Studi di Milano, Milan, Italy., De Santis M; Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy., Murdaca G; Research Hospital San Martino, University of Genoa, Genoa, Italy., Abignano G; Rheumatology Institute of Lucania (IReL) and Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy., Pettiti G; Azienda Ospedaliera S Croce e Carle, Cuneo, Italy., Rossa AD; Department of Rheumatology, University of Pisa, Pisa, Italy., Caminiti M; Departmental Rheumatology Unit, Grande Ospedale Metropolitano, Reggio Calabria, Italy., Iuliano A; Rheumatology Unit, San Camillo - Forlanini Hospital, Rome, Italy., Ciano G; Hospital of Ariano Irpino, Local Health Department, Ariano Irpino, Avellino, Italy., Beretta L; Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano, Milan, Italy., Bagnato G; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy., Lubrano E; Department of Rheumatology, University of Molise, Campobasso, Italy., De Andres MI; Rheumatology Unit, Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione 'Garibaldi,', Catania, Italy., Giollo A; Rheumatology Section, Department of Medicine, University of Verona, Verona, Italy., Bruni C; Division of Rheumatology, Scleroderma Unit, Department of Experimental and Clinical Medicine, AOU Careggi, University of Florence, Florence, Italy., Orlandi M; Rheumatology Unit, Azienda USL IRCCS di Reggio Emilia, Reggio Emilia, Italy., Fornaro M; Rheumatology Unit, Department of Precision and Regenerative Medicine Ionian Area, University of Bari Aldo Moro, Bari, Italy., Saracco M; Rheumatology Unit, Mauriziano-Umberto I Hospital, Torino, Italy., Agnes C; San Lorenzo Hospital, Carmagnola, Turin, Italy., Cerasuolo PG; Division of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Rheumatology, Faculty of Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy., Alonzi G; Division of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Rheumatology, Faculty of Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy., Cipolletta E; Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy., Lumetti F; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy., Spinella A; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy., Magnani L; Rheumatology Unit, Azienda USL IRCCS di Reggio Emilia, Reggio Emilia, Italy., Campochiaro C; Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy., De Luca G; Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy., Codullo V; Department of Internal Medicine and Therapeutics, Università di Pavia, Pavia, Italy.; Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Visalli E; Rheumatology Unit, AOU Policlinico S. Marco, Catania, Italy., Iandoli C; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Caserta, Italy., Gigante A; Department of Translational and Precision Medicine, Sapienza University of Rome, Roma, Italy., Pellegrino G; IRCCS Ospedale Galeazzi Sant'Ambrogio, Milan, Italy.; Dipartimento di Scienze Biomediche e Cliniche, Università degli Studi di Milano, Milan, Italy., Pigatto E; Medicine Unit, Department of Medicine, San Bassiano Hospital, Bassano del Grappa, Italy., Lazzaroni MG; Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Franceschini F; Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Generali E; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy., Mennillo G; Rheumatology Institute of Lucania (IReL) and Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy., Barsotti S; Department of Rheumatology, University of Pisa, Pisa, Italy., Mariano GP; Departmental Rheumatology Unit, Grande Ospedale Metropolitano, Reggio Calabria, Italy., Furini F; Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliera-Universitaria S. Anna di Ferrara, Ferrara, Italy., Vultaggio L; Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliera-Universitaria S. Anna di Ferrara, Ferrara, Italy., Parisi S; Rheumatology Unit, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy., Peroni CL; Rheumatology Unit, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy., Bianchi G; Rheumatology Unit, Department of Musculoskeletal Sciences, Local Health Trust La Colletta Hospital, Genoa, Italy., Fusaro E; Rheumatology Unit, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy., Sebastiani GD; Rheumatology Unit, San Camillo - Forlanini Hospital, Rome, Italy., Govoni M; Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliera-Universitaria S. Anna di Ferrara, Ferrara, Italy., D'Angelo S; Rheumatology Institute of Lucania (IReL) and Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy.; Department of Health Science, University of Basilicata, Potenza, Italy., Cozzi F; Medicine Unit, Department of Medicine, San Bassiano Hospital, Bassano del Grappa, Italy., Conti F; Department of Rheumatology, Sapienza University of Rome, Rome, Italy., Guiducci S; Division of Rheumatology, Scleroderma Unit, Department of Experimental and Clinical Medicine, AOU Careggi, University of Florence, Florence, Italy., Doria A; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy., Salvarani C; Rheumatology Unit, Azienda USL IRCCS di Reggio Emilia, University of Modena and Reggio Emilia, Reggio Emilia, Italy., Iannone F; Rheumatology Unit, Department of Precision and Regenerative Medicine Ionian Area, University of Bari Aldo Moro, Bari, Italy., D'Agostino MA; Division of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Rheumatology, Faculty of Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy., Ferri C; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy., Matucci Cerinic M; Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.; Inflammation Fibrosis and Ageing Initiative (INFLAGE), Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Bosello SL; Division of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Rheumatology, Faculty of Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy.
Corporate Authors: SPRING Italian Registry Collaborators
Source: Arthritis care & research [Arthritis Care Res (Hoboken)] 2025 Dec 29. Date of Electronic Publication: 2025 Dec 29.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101518086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2151-4658 (Electronic) Linking ISSN: 2151464X NLM ISO Abbreviation: Arthritis Care Res (Hoboken) Subsets: MEDLINE
Database: MEDLINE Ultimate
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Mycophenolate Mofetil Treatment Reduces the Risk of Treatment Escalation Due to Vascular Complications in Limited Cutaneous Systemic Sclerosis: Emulation of a Target Trial From the Italian Rheumatology Society SPRING Registry.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22De+Lorenzis+E%22">De Lorenzis E</searchLink>; Division of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Rheumatology, Faculty of Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Natalello+G%22">Natalello G</searchLink>; Division of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Rheumatology, Faculty of Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22De+Angelis+R%22">De Angelis R</searchLink>; Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy.<br /><searchLink fieldCode="AU" term="%22Verardi+L%22">Verardi L</searchLink>; Division of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Rheumatology, Faculty of Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Giuggioli+D%22">Giuggioli D</searchLink>; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Bajocchi+G%22">Bajocchi G</searchLink>; Rheumatology Unit, Azienda USL IRCCS di Reggio Emilia, Reggio Emilia, Italy.<br /><searchLink fieldCode="AU" term="%22Dagna+L%22">Dagna L</searchLink>; Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bellando-Randone+S%22">Bellando-Randone S</searchLink>; Division of Rheumatology, Scleroderma Unit, Department of Experimental and Clinical Medicine, AOU Careggi, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Zanframundo+G%22">Zanframundo G</searchLink>; Department of Internal Medicine and Therapeutics, Università di Pavia, Pavia, Italy.; Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Foti+R%22">Foti R</searchLink>; Rheumatology Unit, AOU Policlinico S. Marco, Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Cacciapaglia+F%22">Cacciapaglia F</searchLink>; Rheumatology Service 'F. Miulli' General Hospital Acquaviva delle Fonti - Department of Medicine and Surgery, LUM University 'Giuseppe De Gennaro' Casamassima, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Cuomo+G%22">Cuomo G</searchLink>; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Caserta, Italy.<br /><searchLink fieldCode="AU" term="%22Ariani+A%22">Ariani A</searchLink>; Department of Medicine, Internal Medicine and Rheumatology, Azienda Ospedaliero Universitaria di Parma, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Rosato+E%22">Rosato E</searchLink>; Department of Translational and Precision Medicine, Sapienza University of Rome, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Lepri+G%22">Lepri G</searchLink>; Division of Rheumatology, Scleroderma Unit, Department of Experimental and Clinical Medicine, AOU Careggi, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Girelli+F%22">Girelli F</searchLink>; Rheumatology Unit, AUSL Romagna, Ospedale G.B. Morgagni, Forlì, Italy.<br /><searchLink fieldCode="AU" term="%22Riccieri+V%22">Riccieri V</searchLink>; Department of Rheumatology, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Zanatta+E%22">Zanatta E</searchLink>; Department of Rheumatology, University of Padua, Padua, Italy.; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Cavazzana+I%22">Cavazzana I</searchLink>; Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Ingegnoli+F%22">Ingegnoli F</searchLink>; Rheumatology Clinic, ASST Pini CTO, Department of Clinical Sciences & Community Health, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22De+Santis+M%22">De Santis M</searchLink>; Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Murdaca+G%22">Murdaca G</searchLink>; Research Hospital San Martino, University of Genoa, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Abignano+G%22">Abignano G</searchLink>; Rheumatology Institute of Lucania (IReL) and Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy.<br /><searchLink fieldCode="AU" term="%22Pettiti+G%22">Pettiti G</searchLink>; Azienda Ospedaliera S Croce e Carle, Cuneo, Italy.<br /><searchLink fieldCode="AU" term="%22Rossa+AD%22">Rossa AD</searchLink>; Department of Rheumatology, University of Pisa, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Caminiti+M%22">Caminiti M</searchLink>; Departmental Rheumatology Unit, Grande Ospedale Metropolitano, Reggio Calabria, Italy.<br /><searchLink fieldCode="AU" term="%22Iuliano+A%22">Iuliano A</searchLink>; Rheumatology Unit, San Camillo - Forlanini Hospital, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Ciano+G%22">Ciano G</searchLink>; Hospital of Ariano Irpino, Local Health Department, Ariano Irpino, Avellino, Italy.<br /><searchLink fieldCode="AU" term="%22Beretta+L%22">Beretta L</searchLink>; Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bagnato+G%22">Bagnato G</searchLink>; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.<br /><searchLink fieldCode="AU" term="%22Lubrano+E%22">Lubrano E</searchLink>; Department of Rheumatology, University of Molise, Campobasso, Italy.<br /><searchLink fieldCode="AU" term="%22De+Andres+MI%22">De Andres MI</searchLink>; Rheumatology Unit, Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione 'Garibaldi,', Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Giollo+A%22">Giollo A</searchLink>; Rheumatology Section, Department of Medicine, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Bruni+C%22">Bruni C</searchLink>; Division of Rheumatology, Scleroderma Unit, Department of Experimental and Clinical Medicine, AOU Careggi, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Orlandi+M%22">Orlandi M</searchLink>; Rheumatology Unit, Azienda USL IRCCS di Reggio Emilia, Reggio Emilia, Italy.<br /><searchLink fieldCode="AU" term="%22Fornaro+M%22">Fornaro M</searchLink>; Rheumatology Unit, Department of Precision and Regenerative Medicine Ionian Area, University of Bari Aldo Moro, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Saracco+M%22">Saracco M</searchLink>; Rheumatology Unit, Mauriziano-Umberto I Hospital, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Agnes+C%22">Agnes C</searchLink>; San Lorenzo Hospital, Carmagnola, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Cerasuolo+PG%22">Cerasuolo PG</searchLink>; Division of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Rheumatology, Faculty of Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Alonzi+G%22">Alonzi G</searchLink>; Division of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Rheumatology, Faculty of Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Cipolletta+E%22">Cipolletta E</searchLink>; Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy.<br /><searchLink fieldCode="AU" term="%22Lumetti+F%22">Lumetti F</searchLink>; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Spinella+A%22">Spinella A</searchLink>; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Magnani+L%22">Magnani L</searchLink>; Rheumatology Unit, Azienda USL IRCCS di Reggio Emilia, Reggio Emilia, Italy.<br /><searchLink fieldCode="AU" term="%22Campochiaro+C%22">Campochiaro C</searchLink>; Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22De+Luca+G%22">De Luca G</searchLink>; Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Codullo+V%22">Codullo V</searchLink>; Department of Internal Medicine and Therapeutics, Università di Pavia, Pavia, Italy.; Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Visalli+E%22">Visalli E</searchLink>; Rheumatology Unit, AOU Policlinico S. Marco, Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Iandoli+C%22">Iandoli C</searchLink>; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Caserta, Italy.<br /><searchLink fieldCode="AU" term="%22Gigante+A%22">Gigante A</searchLink>; Department of Translational and Precision Medicine, Sapienza University of Rome, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Pellegrino+G%22">Pellegrino G</searchLink>; IRCCS Ospedale Galeazzi Sant'Ambrogio, Milan, Italy.; Dipartimento di Scienze Biomediche e Cliniche, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pigatto+E%22">Pigatto E</searchLink>; Medicine Unit, Department of Medicine, San Bassiano Hospital, Bassano del Grappa, Italy.<br /><searchLink fieldCode="AU" term="%22Lazzaroni+MG%22">Lazzaroni MG</searchLink>; Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Franceschini+F%22">Franceschini F</searchLink>; Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Generali+E%22">Generali E</searchLink>; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Mennillo+G%22">Mennillo G</searchLink>; Rheumatology Institute of Lucania (IReL) and Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy.<br /><searchLink fieldCode="AU" term="%22Barsotti+S%22">Barsotti S</searchLink>; Department of Rheumatology, University of Pisa, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Mariano+GP%22">Mariano GP</searchLink>; Departmental Rheumatology Unit, Grande Ospedale Metropolitano, Reggio Calabria, Italy.<br /><searchLink fieldCode="AU" term="%22Furini+F%22">Furini F</searchLink>; Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliera-Universitaria S. Anna di Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Vultaggio+L%22">Vultaggio L</searchLink>; Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliera-Universitaria S. Anna di Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Parisi+S%22">Parisi S</searchLink>; Rheumatology Unit, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Peroni+CL%22">Peroni CL</searchLink>; Rheumatology Unit, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Bianchi+G%22">Bianchi G</searchLink>; Rheumatology Unit, Department of Musculoskeletal Sciences, Local Health Trust La Colletta Hospital, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Fusaro+E%22">Fusaro E</searchLink>; Rheumatology Unit, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Sebastiani+GD%22">Sebastiani GD</searchLink>; Rheumatology Unit, San Camillo - Forlanini Hospital, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Govoni+M%22">Govoni M</searchLink>; Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliera-Universitaria S. Anna di Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22D'Angelo+S%22">D'Angelo S</searchLink>; Rheumatology Institute of Lucania (IReL) and Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy.; Department of Health Science, University of Basilicata, Potenza, Italy.<br /><searchLink fieldCode="AU" term="%22Cozzi+F%22">Cozzi F</searchLink>; Medicine Unit, Department of Medicine, San Bassiano Hospital, Bassano del Grappa, Italy.<br /><searchLink fieldCode="AU" term="%22Conti+F%22">Conti F</searchLink>; Department of Rheumatology, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Guiducci+S%22">Guiducci S</searchLink>; Division of Rheumatology, Scleroderma Unit, Department of Experimental and Clinical Medicine, AOU Careggi, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Doria+A%22">Doria A</searchLink>; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Salvarani+C%22">Salvarani C</searchLink>; Rheumatology Unit, Azienda USL IRCCS di Reggio Emilia, University of Modena and Reggio Emilia, Reggio Emilia, Italy.<br /><searchLink fieldCode="AU" term="%22Iannone+F%22">Iannone F</searchLink>; Rheumatology Unit, Department of Precision and Regenerative Medicine Ionian Area, University of Bari Aldo Moro, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22D'Agostino+MA%22">D'Agostino MA</searchLink>; Division of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Rheumatology, Faculty of Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Ferri+C%22">Ferri C</searchLink>; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Matucci+Cerinic+M%22">Matucci Cerinic M</searchLink>; Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.; Inflammation Fibrosis and Ageing Initiative (INFLAGE), Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bosello+SL%22">Bosello SL</searchLink>; Division of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Rheumatology, Faculty of Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy.
– Name: AuthorCorporate
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  Data: <searchLink fieldCode="CA" term="%22SPRING+Italian+Registry+Collaborators%22">SPRING Italian Registry Collaborators</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22101518086%22">Arthritis care & research</searchLink> [Arthritis Care Res (Hoboken)] 2025 Dec 29. <i>Date of Electronic Publication: </i>2025 Dec 29.
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  Data: Journal Article
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%22">John Wiley & Sons </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101518086 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2151-4658 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222151464X%22">2151464X </searchLink><i>NLM ISO Abbreviation: </i>Arthritis Care Res (Hoboken) <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41466450
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      – Type: doi
        Value: 10.1002/acr.70039
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      – Code: eng
        Text: English
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      – TitleFull: Mycophenolate Mofetil Treatment Reduces the Risk of Treatment Escalation Due to Vascular Complications in Limited Cutaneous Systemic Sclerosis: Emulation of a Target Trial From the Italian Rheumatology Society SPRING Registry.
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              Text: 2025 Dec 29
              Type: published
              Y: 2025
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            – Type: issn-electronic
              Value: 2151-4658
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            – TitleFull: Arthritis care & research
              Type: main
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