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Mutant p53 promotes clonal hematopoiesis by generating a chronic inflammatory microenvironment.

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Title: Mutant p53 promotes clonal hematopoiesis by generating a chronic inflammatory microenvironment.
Authors: Chen S; Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Barajas S; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Department of Biochemistry and Molecular Biology, and., Vemula S; Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA., Yang Y; Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Medical Genetics, School of Basic Medical Sciences, Peking University, Beijing, China., Simpson E; Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Gao H; Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Li R; Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Behzadnia F; Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Nabinger SC; Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA., Schmitz DA; Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA., Chen H; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Department of Hematology and Oncology, Chongqing University Three Gorges Hospital, Chongqing, China., Cai W; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Department of Biochemistry and Molecular Biology, and., Xiao S; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Luo R; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Amin MA; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Capitano ML; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA., Ropa JP; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA., Fahey A; Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA., Zhou S; Precision Research Center for Refractory Diseases, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Mays TM; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Sotelo M; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Pan H; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Hu SK; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Veranga S; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Ali M; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Shumilina M; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Kapur R; Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA., Ren K; Department of Pathology and., Jia Y; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Liu H; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois, USA., Khan I; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois, USA., Abaza Y; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois, USA., Altman JK; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois, USA., Eklund EA; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois, USA.; Department of Medicine, Jesse Brown VA Medical Center, Chicago, Illinois, USA., Godley LA; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois, USA., Zhang CR; Department of Pathology and.; Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois, USA., Ji P; Department of Pathology and.; Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois, USA., Masters SL; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Croker BA; Department of Pediatrics, University of California San Diego, La Jolla, California, USA., Boswell HS; Department of Medicine and., Sandusky GE; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA., Gao Z; Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania, USA., Mayo LD; Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA., Savage SA; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA., Halene S; Department of Internal Medicine and Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut, USA., Dou Y; Department of Medicine, University of Southern California, Los Angeles, California, USA., Platanias LC; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois, USA.; Department of Medicine, Jesse Brown VA Medical Center, Chicago, Illinois, USA., Sukhanova M; Department of Pathology and.; Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois, USA., Liu Y; Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Abdel-Wahab O; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Liu Y; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois, USA.
Source: The Journal of clinical investigation [J Clin Invest] 2025 Dec 30; Vol. 136 (3). Date of Electronic Publication: 2025 Dec 30 (Print Publication: 2026).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
Database: MEDLINE Ultimate
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