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Multiscale mitochondrial cristae remodeling links Opa1 downregulation to reduced OXPHOS capacity in aged hearts.

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Title: Multiscale mitochondrial cristae remodeling links Opa1 downregulation to reduced OXPHOS capacity in aged hearts.
Authors: Molina-Riquelme I; Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago de Chile 8331150, Chile., Barrientos G; Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago de Chile 8331150, Chile., Breitsprecher L; Center of Cellular Nanoanalytics, Integrated Bioimaging Facility, University of Osnabrück, Osnabrück, Lower Saxony 49076, Germany., Gómez W; Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago de Chile 8331150, Chile., Díaz-Castro F; Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago de Chile 8331150, Chile., Morris S; Institute of Integrative Cell Biology and Physiology, Faculty of Biology, University of Muenster, Muenster, North-Rhine-Westphalia 48149, Germany., Almarza G; Laboratorio de Fisiología y Bioenergética Celular, Departamento de Farmacia, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago de Chile 7820436, Chile., Del Campo A; Laboratorio de Fisiología y Bioenergética Celular, Departamento de Farmacia, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago de Chile 7820436, Chile., Garrido-Olivares L; Laboratorio de Fisiología y Bioenergética Celular, Departamento de Farmacia, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago de Chile 7820436, Chile., Verdejo HE; Facultad de Medicina, División de Cirugía, Pontificia Universidad Católica de Chile, Santiago de Chile 8331150, Chile., Psathaki OE; Center of Cellular Nanoanalytics, Integrated Bioimaging Facility, University of Osnabrück, Osnabrück, Lower Saxony 49076, Germany., Busch KB; Institute of Integrative Cell Biology and Physiology, Faculty of Biology, University of Muenster, Muenster, North-Rhine-Westphalia 48149, Germany., Eisner V; Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago de Chile 8331150, Chile.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jan 06; Vol. 123 (1), pp. e2508911123. Date of Electronic Publication: 2025 Dec 30.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Multiscale mitochondrial cristae remodeling links Opa1 downregulation to reduced OXPHOS capacity in aged hearts.
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  Data: <searchLink fieldCode="AU" term="%22Molina-Riquelme+I%22">Molina-Riquelme I</searchLink>; Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago de Chile 8331150, Chile.<br /><searchLink fieldCode="AU" term="%22Barrientos+G%22">Barrientos G</searchLink>; Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago de Chile 8331150, Chile.<br /><searchLink fieldCode="AU" term="%22Breitsprecher+L%22">Breitsprecher L</searchLink>; Center of Cellular Nanoanalytics, Integrated Bioimaging Facility, University of Osnabrück, Osnabrück, Lower Saxony 49076, Germany.<br /><searchLink fieldCode="AU" term="%22Gómez+W%22">Gómez W</searchLink>; Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago de Chile 8331150, Chile.<br /><searchLink fieldCode="AU" term="%22Díaz-Castro+F%22">Díaz-Castro F</searchLink>; Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago de Chile 8331150, Chile.<br /><searchLink fieldCode="AU" term="%22Morris+S%22">Morris S</searchLink>; Institute of Integrative Cell Biology and Physiology, Faculty of Biology, University of Muenster, Muenster, North-Rhine-Westphalia 48149, Germany.<br /><searchLink fieldCode="AU" term="%22Almarza+G%22">Almarza G</searchLink>; Laboratorio de Fisiología y Bioenergética Celular, Departamento de Farmacia, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago de Chile 7820436, Chile.<br /><searchLink fieldCode="AU" term="%22Del+Campo+A%22">Del Campo A</searchLink>; Laboratorio de Fisiología y Bioenergética Celular, Departamento de Farmacia, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago de Chile 7820436, Chile.<br /><searchLink fieldCode="AU" term="%22Garrido-Olivares+L%22">Garrido-Olivares L</searchLink>; Laboratorio de Fisiología y Bioenergética Celular, Departamento de Farmacia, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago de Chile 7820436, Chile.<br /><searchLink fieldCode="AU" term="%22Verdejo+HE%22">Verdejo HE</searchLink>; Facultad de Medicina, División de Cirugía, Pontificia Universidad Católica de Chile, Santiago de Chile 8331150, Chile.<br /><searchLink fieldCode="AU" term="%22Psathaki+OE%22">Psathaki OE</searchLink>; Center of Cellular Nanoanalytics, Integrated Bioimaging Facility, University of Osnabrück, Osnabrück, Lower Saxony 49076, Germany.<br /><searchLink fieldCode="AU" term="%22Busch+KB%22">Busch KB</searchLink>; Institute of Integrative Cell Biology and Physiology, Faculty of Biology, University of Muenster, Muenster, North-Rhine-Westphalia 48149, Germany.<br /><searchLink fieldCode="AU" term="%22Eisner+V%22">Eisner V</searchLink>; Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago de Chile 8331150, Chile.
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