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A multi-centre performance evaluation of a commercially developed liquid biopsy for the earlier detection of brain tumours.

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Title: A multi-centre performance evaluation of a commercially developed liquid biopsy for the earlier detection of brain tumours.
Authors: Brennan PM; Translational Neurosurgery, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. Electronic address: Paul.Brennan@ed.ac.uk., Cameron JM; Dxcover Ltd, Royal College Building, Suite RC534, Glasgow, UK., Eustace D; Dxcover Ltd, Royal College Building, Suite RC534, Glasgow, UK., Butler HJ; Dxcover Ltd, Royal College Building, Suite RC534, Glasgow, UK., Sala A; Dxcover Ltd, Royal College Building, Suite RC534, Glasgow, UK., Lazarus A; Dxcover Ltd, Royal College Building, Suite RC534, Glasgow, UK., Antoniou G; Dxcover Ltd, Royal College Building, Suite RC534, Glasgow, UK., Palmer DS; Dxcover Ltd, Royal College Building, Suite RC534, Glasgow, UK; Department of Chemistry, University of Strathclyde, Glasgow, UK., Gray E; Freelance Consultant, Edinburgh, UK., Kerrie C; Edinburgh Clinical Trials Unit, University of Edinburgh, Edinburgh, UK., McDonald S; Emergency Medicine Research Group of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK., Black P; Emergency Medicine Research Group of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK., Sheraz S; Translational Neurosurgery, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Adekoya I; Emergency Medicine Research Group of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK., Jakola A; Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, University of Gothenburg, Sahlgrenska Academy, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Neurosurgery, Gothenburg, Sweden., Denes A; Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, University of Gothenburg, Sahlgrenska Academy, Gothenburg, Sweden., Jenkinson MD; The Walton Centre, NHS Foundation Trust Liverpool, Liverpool, UK., Jones J; The Walton Centre, NHS Foundation Trust Liverpool, Liverpool, UK., Pendered S; The Walton Centre, NHS Foundation Trust Liverpool, Liverpool, UK., Koljenovic S; Department of Pathology, Universitair Ziekenhuis Antwerpen (UZA), Antwerp, Belgium., Zwaenepoel K; Department of Pathology, Universitair Ziekenhuis Antwerpen (UZA), Antwerp, Belgium., Sieben A; Department of Pathology, Universitair Ziekenhuis Antwerpen (UZA), Antwerp, Belgium., Ahmed M; Department of Pathology, Universitair Ziekenhuis Antwerpen (UZA), Antwerp, Belgium., Feyen B; Department of Pathology, Universitair Ziekenhuis Antwerpen (UZA), Antwerp, Belgium., Mathew RK; Department of Neurosurgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK; School of Medicine, University of Leeds, Leeds, UK., Coils C; Department of Neurosurgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK., Ismail A; School of Medicine, University of Leeds, Leeds, UK., Phang I; Lancashire Clinical Research Facility, Royal Preston Hospital, Preston, UK., Brown A; Lancashire Clinical Research Facility, Royal Preston Hospital, Preston, UK., Patel S; Lancashire Clinical Research Facility, Royal Preston Hospital, Preston, UK., Weiss T; Klinik für Neurologie, Universitätsspital Zürich (USZ), Zurich, Switzerland., Westarp PW; Klinik für Neurologie, Universitätsspital Zürich (USZ), Zurich, Switzerland., Kopp A; Klinik für Neurologie, Universitätsspital Zürich (USZ), Zurich, Switzerland., Baker MJ; Dxcover Ltd, Royal College Building, Suite RC534, Glasgow, UK; School of Medicine & Dentistry, University of Lancashire, Preston, UK. Electronic address: matthew.baker@dxcover.com.
Source: ESMO open [ESMO Open] 2026 Jan; Vol. 11 (1), pp. 105938. Date of Electronic Publication: 2025 Dec 29.
Publication Type: Journal Article; Multicenter Study; Observational Study
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101690685 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2059-7029 (Electronic) Linking ISSN: 20597029 NLM ISO Abbreviation: ESMO Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A multi-centre performance evaluation of a commercially developed liquid biopsy for the earlier detection of brain tumours.
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  Data: <searchLink fieldCode="AU" term="%22Brennan+PM%22">Brennan PM</searchLink>; Translational Neurosurgery, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. Electronic address: Paul.Brennan@ed.ac.uk.<br /><searchLink fieldCode="AU" term="%22Cameron+JM%22">Cameron JM</searchLink>; Dxcover Ltd, Royal College Building, Suite RC534, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Eustace+D%22">Eustace D</searchLink>; Dxcover Ltd, Royal College Building, Suite RC534, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Butler+HJ%22">Butler HJ</searchLink>; Dxcover Ltd, Royal College Building, Suite RC534, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Sala+A%22">Sala A</searchLink>; Dxcover Ltd, Royal College Building, Suite RC534, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Lazarus+A%22">Lazarus A</searchLink>; Dxcover Ltd, Royal College Building, Suite RC534, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Antoniou+G%22">Antoniou G</searchLink>; Dxcover Ltd, Royal College Building, Suite RC534, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Palmer+DS%22">Palmer DS</searchLink>; Dxcover Ltd, Royal College Building, Suite RC534, Glasgow, UK; Department of Chemistry, University of Strathclyde, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Gray+E%22">Gray E</searchLink>; Freelance Consultant, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Kerrie+C%22">Kerrie C</searchLink>; Edinburgh Clinical Trials Unit, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22McDonald+S%22">McDonald S</searchLink>; Emergency Medicine Research Group of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Black+P%22">Black P</searchLink>; Emergency Medicine Research Group of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Sheraz+S%22">Sheraz S</searchLink>; Translational Neurosurgery, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Adekoya+I%22">Adekoya I</searchLink>; Emergency Medicine Research Group of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Jakola+A%22">Jakola A</searchLink>; Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, University of Gothenburg, Sahlgrenska Academy, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Neurosurgery, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Denes+A%22">Denes A</searchLink>; Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, University of Gothenburg, Sahlgrenska Academy, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Jenkinson+MD%22">Jenkinson MD</searchLink>; The Walton Centre, NHS Foundation Trust Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Jones+J%22">Jones J</searchLink>; The Walton Centre, NHS Foundation Trust Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Pendered+S%22">Pendered S</searchLink>; The Walton Centre, NHS Foundation Trust Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Koljenovic+S%22">Koljenovic S</searchLink>; Department of Pathology, Universitair Ziekenhuis Antwerpen (UZA), Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Zwaenepoel+K%22">Zwaenepoel K</searchLink>; Department of Pathology, Universitair Ziekenhuis Antwerpen (UZA), Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Sieben+A%22">Sieben A</searchLink>; Department of Pathology, Universitair Ziekenhuis Antwerpen (UZA), Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Ahmed+M%22">Ahmed M</searchLink>; Department of Pathology, Universitair Ziekenhuis Antwerpen (UZA), Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Feyen+B%22">Feyen B</searchLink>; Department of Pathology, Universitair Ziekenhuis Antwerpen (UZA), Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Mathew+RK%22">Mathew RK</searchLink>; Department of Neurosurgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK; School of Medicine, University of Leeds, Leeds, UK.<br /><searchLink fieldCode="AU" term="%22Coils+C%22">Coils C</searchLink>; Department of Neurosurgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK.<br /><searchLink fieldCode="AU" term="%22Ismail+A%22">Ismail A</searchLink>; School of Medicine, University of Leeds, Leeds, UK.<br /><searchLink fieldCode="AU" term="%22Phang+I%22">Phang I</searchLink>; Lancashire Clinical Research Facility, Royal Preston Hospital, Preston, UK.<br /><searchLink fieldCode="AU" term="%22Brown+A%22">Brown A</searchLink>; Lancashire Clinical Research Facility, Royal Preston Hospital, Preston, UK.<br /><searchLink fieldCode="AU" term="%22Patel+S%22">Patel S</searchLink>; Lancashire Clinical Research Facility, Royal Preston Hospital, Preston, UK.<br /><searchLink fieldCode="AU" term="%22Weiss+T%22">Weiss T</searchLink>; Klinik für Neurologie, Universitätsspital Zürich (USZ), Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Westarp+PW%22">Westarp PW</searchLink>; Klinik für Neurologie, Universitätsspital Zürich (USZ), Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kopp+A%22">Kopp A</searchLink>; Klinik für Neurologie, Universitätsspital Zürich (USZ), Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Baker+MJ%22">Baker MJ</searchLink>; Dxcover Ltd, Royal College Building, Suite RC534, Glasgow, UK; School of Medicine & Dentistry, University of Lancashire, Preston, UK. Electronic address: matthew.baker@dxcover.com.
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  Data: <searchLink fieldCode="JN" term="%22101690685%22">ESMO open</searchLink> [ESMO Open] 2026 Jan; Vol. 11 (1), pp. 105938. <i>Date of Electronic Publication: </i>2025 Dec 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101690685 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2059-7029 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220597029%22">20597029 </searchLink><i>NLM ISO Abbreviation: </i>ESMO Open <i>Subsets: </i>MEDLINE
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