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Naphthalimide-nitrosourea derivatives as dual-function antitumor agents for exploration of their action mechanisms and chemical degradation process.

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Title: Naphthalimide-nitrosourea derivatives as dual-function antitumor agents for exploration of their action mechanisms and chemical degradation process.
Authors: Han ZY; Qingdao Key Laboratory of Biomacromolecular Drug Discovery and Development, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, People's Republic of China., Jia ZH; Qingdao Key Laboratory of Biomacromolecular Drug Discovery and Development, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, People's Republic of China., Meng FX; Qingdao Key Laboratory of Biomacromolecular Drug Discovery and Development, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, People's Republic of China., Yu RL; Key laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China., Wang Q; Shandong Xinhua Pharmaceutical Co., Ltd., Zibo 255075, People's Republic of China., Xia YM; Qingdao Key Laboratory of Biomacromolecular Drug Discovery and Development, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, People's Republic of China. Electronic address: xiayamu@126.com., Gao WW; Qingdao Key Laboratory of Biomacromolecular Drug Discovery and Development, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, People's Republic of China. Electronic address: gww501@qust.edu.cn.
Source: Bioorganic chemistry [Bioorg Chem] 2026 Feb; Vol. 169, pp. 109435. Date of Electronic Publication: 2025 Dec 26.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Naphthalimide-nitrosourea derivatives as dual-function antitumor agents for exploration of their action mechanisms and chemical degradation process.
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  Data: <searchLink fieldCode="AU" term="%22Han+ZY%22">Han ZY</searchLink>; Qingdao Key Laboratory of Biomacromolecular Drug Discovery and Development, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Jia+ZH%22">Jia ZH</searchLink>; Qingdao Key Laboratory of Biomacromolecular Drug Discovery and Development, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Meng+FX%22">Meng FX</searchLink>; Qingdao Key Laboratory of Biomacromolecular Drug Discovery and Development, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Yu+RL%22">Yu RL</searchLink>; Key laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Shandong Xinhua Pharmaceutical Co., Ltd., Zibo 255075, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Xia+YM%22">Xia YM</searchLink>; Qingdao Key Laboratory of Biomacromolecular Drug Discovery and Development, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, People's Republic of China. Electronic address: xiayamu@126.com.<br /><searchLink fieldCode="AU" term="%22Gao+WW%22">Gao WW</searchLink>; Qingdao Key Laboratory of Biomacromolecular Drug Discovery and Development, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, People's Republic of China. Electronic address: gww501@qust.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%221303703%22">Bioorganic chemistry</searchLink> [Bioorg Chem] 2026 Feb; Vol. 169, pp. 109435. <i>Date of Electronic Publication: </i>2025 Dec 26.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>1303703 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1090-2120 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200452068%22">00452068 </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.bioorg.2025.109435
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        Text: English
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      – TitleFull: Naphthalimide-nitrosourea derivatives as dual-function antitumor agents for exploration of their action mechanisms and chemical degradation process.
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              Text: 2026 Feb
              Type: published
              Y: 2026
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