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Intratumoral delivery of FLT3L with CXCR3/CCR5 ligands promotes XCR1+ cDC1 infiltration and activates anti-tumor immunity.

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Title: Intratumoral delivery of FLT3L with CXCR3/CCR5 ligands promotes XCR1+ cDC1 infiltration and activates anti-tumor immunity.
Authors: Gorline L; Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France.; CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France.; Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France., do Carmo FLR; Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France.; CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France.; Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France., Bourdely P; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, VIB, Leuven, Belgium.; INSERM UMR 1016, CNRS UMR 8104, Institut Cochin, Université Paris Cité, Paris, France., Bornères J; Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France.; CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France.; Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France., Vaudiau N; Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France.; CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France.; Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France., Semervil A; Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France.; CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France.; Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France.; INSERM UMR 1016, CNRS UMR 8104, Institut Cochin, Université Paris Cité, Paris, France., Vetillard M; Bichat Medical School, INSERM UMR1149, CNRS EMR8252, Université Paris Cité, Paris, France., Coulibaly ASK; Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France.; CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France.; Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France., Jugniot N; Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France.; CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France.; Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France., Ok A; Bichat Medical School, INSERM UMR1149, CNRS EMR8252, Université Paris Cité, Paris, France., Bausart M; Department of Pathology and Immunology, Geneva Medical School, Geneva, Switzerland., Fiquet O; Human Disease Models Core Facility, Institut Pasteur, Université Paris Cité, Paris, France., Andrade M; Human Disease Models Core Facility, Institut Pasteur, Université Paris Cité, Paris, France., Fardol D; Nutrition and Obesity: Systemic Approaches, Inserm, Sorbonne University, Paris, France., Haddar I; Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France.; CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France.; Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France., Abou Nader Z; INSERM UMR 1016, CNRS UMR 8104, Institut Cochin, Université Paris Cité, Paris, France., Weber J; INSERM UMR 1016, CNRS UMR 8104, Institut Cochin, Université Paris Cité, Paris, France., Theobald H; Inserm U1015, Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France., Collin M; Inserm Transfert, Paris, France., Calmette J; Inserm Transfert, Paris, France., Anselmi G; Deparment of Cellular Immunology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy., Fico F; Department of Pathology and Immunology, Geneva Medical School, Geneva, Switzerland., Ginhoux F; Inserm U1015, Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France., Majlessi L; Virology Department, Pasteur-TheraVectys Joint Laboratory, Institut Pasteur, Université Paris Cité, Paris, France., Gautier EL; Nutrition and Obesity: Systemic Approaches, Inserm, Sorbonne University, Paris, France., Saveanu L; Bichat Medical School, INSERM UMR1149, CNRS EMR8252, Université Paris Cité, Paris, France., Helft J; INSERM UMR 1016, CNRS UMR 8104, Institut Cochin, Université Paris Cité, Paris, France., Dalod M; Centre d'Immunologie de Marseille-Luminy, CIML, CNRS, INSERM, Aix Marseille Université, Marseille, France., Dusseaux M; Human Disease Models Core Facility, Institut Pasteur, Université Paris Cité, Paris, France., Di Santo JP; Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France.; Immunology Department, Immunité Innée, Institut Pasteur, Paris, France., Hugues S; Department of Pathology and Immunology, Geneva Medical School, Geneva, Switzerland., Guermonprez P; Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France. pierre.guermonprez@pasteur.fr.; CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France. pierre.guermonprez@pasteur.fr.; Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France. pierre.guermonprez@pasteur.fr.
Source: Nature communications [Nat Commun] 2025 Dec 30; Vol. 17 (1), pp. 1258. Date of Electronic Publication: 2025 Dec 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Intratumoral delivery of FLT3L with CXCR3/CCR5 ligands promotes XCR1<superscript>+</superscript> cDC1 infiltration and activates anti-tumor immunity.
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  Data: <searchLink fieldCode="AU" term="%22Gorline+L%22">Gorline L</searchLink>; Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France.; CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France.; Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France.<br /><searchLink fieldCode="AU" term="%22do+Carmo+FLR%22">do Carmo FLR</searchLink>; Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France.; CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France.; Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bourdely+P%22">Bourdely P</searchLink>; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, VIB, Leuven, Belgium.; INSERM UMR 1016, CNRS UMR 8104, Institut Cochin, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bornères+J%22">Bornères J</searchLink>; Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France.; CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France.; Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France.<br /><searchLink fieldCode="AU" term="%22Vaudiau+N%22">Vaudiau N</searchLink>; Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France.; CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France.; Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France.<br /><searchLink fieldCode="AU" term="%22Semervil+A%22">Semervil A</searchLink>; Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France.; CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France.; Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France.; INSERM UMR 1016, CNRS UMR 8104, Institut Cochin, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Vetillard+M%22">Vetillard M</searchLink>; Bichat Medical School, INSERM UMR1149, CNRS EMR8252, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Coulibaly+ASK%22">Coulibaly ASK</searchLink>; Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France.; CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France.; Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France.<br /><searchLink fieldCode="AU" term="%22Jugniot+N%22">Jugniot N</searchLink>; Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France.; CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France.; Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France.<br /><searchLink fieldCode="AU" term="%22Ok+A%22">Ok A</searchLink>; Bichat Medical School, INSERM UMR1149, CNRS EMR8252, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bausart+M%22">Bausart M</searchLink>; Department of Pathology and Immunology, Geneva Medical School, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Fiquet+O%22">Fiquet O</searchLink>; Human Disease Models Core Facility, Institut Pasteur, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Andrade+M%22">Andrade M</searchLink>; Human Disease Models Core Facility, Institut Pasteur, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Fardol+D%22">Fardol D</searchLink>; Nutrition and Obesity: Systemic Approaches, Inserm, Sorbonne University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Haddar+I%22">Haddar I</searchLink>; Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France.; 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Department of Pathology and Immunology, Geneva Medical School, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ginhoux+F%22">Ginhoux F</searchLink>; Inserm U1015, Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Majlessi+L%22">Majlessi L</searchLink>; Virology Department, Pasteur-TheraVectys Joint Laboratory, Institut Pasteur, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Gautier+EL%22">Gautier EL</searchLink>; Nutrition and Obesity: Systemic Approaches, Inserm, Sorbonne University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Saveanu+L%22">Saveanu L</searchLink>; Bichat Medical School, INSERM UMR1149, CNRS EMR8252, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Helft+J%22">Helft J</searchLink>; INSERM UMR 1016, CNRS UMR 8104, Institut Cochin, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Dalod+M%22">Dalod M</searchLink>; Centre d'Immunologie de Marseille-Luminy, CIML, CNRS, INSERM, Aix Marseille Université, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Dusseaux+M%22">Dusseaux M</searchLink>; Human Disease Models Core Facility, Institut Pasteur, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Di+Santo+JP%22">Di Santo JP</searchLink>; Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France.; Immunology Department, Immunité Innée, Institut Pasteur, Paris, France.<br /><searchLink fieldCode="AU" term="%22Hugues+S%22">Hugues S</searchLink>; Department of Pathology and Immunology, Geneva Medical School, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Guermonprez+P%22">Guermonprez P</searchLink>; Dendritic Cells and Adaptive Immunity Unit, Immunology Department, Institut Pasteur, Université de Paris Cité, Paris, France. pierre.guermonprez@pasteur.fr.; CNRS UMR3738, Developmental Biology and Stem Cells, Institut Pasteur, Université de Paris Cité, Paris, France. pierre.guermonprez@pasteur.fr.; Centre for Vaccine and Immunotherapy, Institut Pasteur, Paris, France. pierre.guermonprez@pasteur.fr.
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