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Novel anti-ITGA4 monoclonal antibody induces cell death via large pore formation in NK/T-cell lymphoma cells.

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Title: Novel anti-ITGA4 monoclonal antibody induces cell death via large pore formation in NK/T-cell lymphoma cells.
Authors: Takeuchi S; Department of Obstetrics and Gynecology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.; Department of Immunological Diagnosis, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan., Ito Y; Department of Immunological Diagnosis, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan., Matsuoka S; Department of Immunological Diagnosis, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. matsuoka@juntendo.ac.jp.; Division of Cancer Immunotherapy, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan. matsuoka@juntendo.ac.jp., Abe M; Department of Immunological Diagnosis, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan., Tsurui H; Department of Immunological Diagnosis, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan., Horimoto Y; Department of Breast Surgery and Oncology, Tokyo Medical University, Tokyo, Japan., Fukuhara T; Neurodegenerative Disorders Collaboration Laboratory, RIKEN Center for Brain Science, Wako, Japan.; Department of Neurology, Graduate School of Medicine, Juntendo University, Tokyo, Japan., Hirano T; Department of Immunological Diagnosis, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan., Mizutani N; Department of Immunological Diagnosis, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.; Department of Medical Technology, Faculty of Health Science, Kyorin University, Tokyo, Japan., Ito T; Department of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University, Tokyo, Japan., Hatano R; Department of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University, Tokyo, Japan., Nakao A; Department of Immunology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.; Atopy (Allergy) Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan., Terao Y; Department of Obstetrics and Gynecology, Graduate School of Medicine, Juntendo University, Tokyo, Japan., Kitade M; Department of Obstetrics and Gynecology, Graduate School of Medicine, Juntendo University, Tokyo, Japan., Hamano Y; Department of Immunological Diagnosis, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan., Takamatsu H; Faculty of Transdisciplinary Sciences for Innovation, Institute of Transdisciplinary Sciences for Innovation, Kanazawa University, Kanazawa, Japan., Matsuoka H; Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan., Nakatsura T; Division of Cancer Immunotherapy, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan., Yagita H; Department of Immunological Diagnosis, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan., Okumura K; Atopy (Allergy) Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan., Itakura A; Department of Obstetrics and Gynecology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Source: Scientific reports [Sci Rep] 2025 Dec 30; Vol. 15 (1), pp. 45655. Date of Electronic Publication: 2025 Dec 30.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Novel anti-ITGA4 monoclonal antibody induces cell death via large pore formation in NK/T-cell lymphoma cells.
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  Data: <searchLink fieldCode="AU" term="%22Takeuchi+S%22">Takeuchi S</searchLink>; Department of Obstetrics and Gynecology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.; Department of Immunological Diagnosis, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.<br /><searchLink fieldCode="AU" term="%22Ito+Y%22">Ito Y</searchLink>; Department of Immunological Diagnosis, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.<br /><searchLink fieldCode="AU" term="%22Matsuoka+S%22">Matsuoka S</searchLink>; Department of Immunological Diagnosis, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. matsuoka@juntendo.ac.jp.; Division of Cancer Immunotherapy, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan. matsuoka@juntendo.ac.jp.<br /><searchLink fieldCode="AU" term="%22Abe+M%22">Abe M</searchLink>; Department of Immunological Diagnosis, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.<br /><searchLink fieldCode="AU" term="%22Tsurui+H%22">Tsurui H</searchLink>; Department of Immunological Diagnosis, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.<br /><searchLink fieldCode="AU" term="%22Horimoto+Y%22">Horimoto Y</searchLink>; Department of Breast Surgery and Oncology, Tokyo Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Fukuhara+T%22">Fukuhara T</searchLink>; Neurodegenerative Disorders Collaboration Laboratory, RIKEN Center for Brain Science, Wako, Japan.; Department of Neurology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hirano+T%22">Hirano T</searchLink>; Department of Immunological Diagnosis, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.<br /><searchLink fieldCode="AU" term="%22Mizutani+N%22">Mizutani N</searchLink>; Department of Immunological Diagnosis, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.; Department of Medical Technology, Faculty of Health Science, Kyorin University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ito+T%22">Ito T</searchLink>; Department of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hatano+R%22">Hatano R</searchLink>; Department of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nakao+A%22">Nakao A</searchLink>; Department of Immunology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.; Atopy (Allergy) Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Terao+Y%22">Terao Y</searchLink>; Department of Obstetrics and Gynecology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kitade+M%22">Kitade M</searchLink>; Department of Obstetrics and Gynecology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hamano+Y%22">Hamano Y</searchLink>; Department of Immunological Diagnosis, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.<br /><searchLink fieldCode="AU" term="%22Takamatsu+H%22">Takamatsu H</searchLink>; Faculty of Transdisciplinary Sciences for Innovation, Institute of Transdisciplinary Sciences for Innovation, Kanazawa University, Kanazawa, Japan.<br /><searchLink fieldCode="AU" term="%22Matsuoka+H%22">Matsuoka H</searchLink>; Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.<br /><searchLink fieldCode="AU" term="%22Nakatsura+T%22">Nakatsura T</searchLink>; Division of Cancer Immunotherapy, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan.<br /><searchLink fieldCode="AU" term="%22Yagita+H%22">Yagita H</searchLink>; Department of Immunological Diagnosis, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.<br /><searchLink fieldCode="AU" term="%22Okumura+K%22">Okumura K</searchLink>; Atopy (Allergy) Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Itakura+A%22">Itakura A</searchLink>; Department of Obstetrics and Gynecology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
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