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Synthesis of Novel Arylhydrazones Bearing 8-Trifluoromethyl Quinoline: Crystal Insights, Larvicidal Activity, ADMET Predictions, and Molecular Docking Studies.

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Title: Synthesis of Novel Arylhydrazones Bearing 8-Trifluoromethyl Quinoline: Crystal Insights, Larvicidal Activity, ADMET Predictions, and Molecular Docking Studies.
Authors: Kotyan S; Department of Chemistry, Mangalore University, Mangalagangotri 574199, Karnataka, India., Chandana SN; Department of Physics, Rajeev Institute of Technology, Hassan 573201, Karnataka, India., Ganesha DP; Department of Physics, Malnad College of Engineering, Affiliated to Visvesvaraya Technological University, Hassan 573201, Karnataka, India., Lakshminarayana BN; Research Center, Department of Physics, Adichunchanagiri Institute of Technology, Affiliated to Visvesvaraya Technological University, Jyothinagara, Chikkamagaluru 577102, Karnataka, India., Pandikatte N; Department of PG Studies and Research in Chemistry, Sri Dharmasthala Manjunatheshwara College (Autonomous), Ujire 574240, Karnataka, India., Deb PK; Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology (BIT), Mesra 835215, Jharkhand, India., Ghosh M; Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology (BIT), Mesra 835215, Jharkhand, India., Gleiser RM; CREAN-IMBIV (UNC-CONICET), Av. Valparaiso s.n., and FCEFyN, Universidad Nacional de Cordoba, Av. V. Sarsfield 299, Cordoba 5000, Argentina., Mahomoodally MF; Institute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam.; School of Engineering & Technology, Duy Tan University, Da Nang 550000, Vietnam.; Laboratory of Natural Products and Medicinal Chemistry (LNPMC), Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam, Chennai 602105, Tamil Nadu, India.; Centre of Excellence for Pharmaceutical Sciences (Pharmacen), North West University, Potchefstroom 2520, South Africa.; Department of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Reduit 80837, Mauritius., Alherz SA; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia., Morsy MA; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia., Khalil HE; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia., Attimarad M; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia., Nagaraja S; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia., Almuqbil RM; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia., Balgoname AA; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia., Al-Dhubiab BE; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia., Asif AH; Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia., Venugopala KN; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia.; Department of Biotechnology and Food Science, Faculty of Applied Sciences, Durban University of Technology, Durban 4001, South Africa., Dasappa JP; Department of Chemistry, Mangalore University, Mangalagangotri 574199, Karnataka, India.
Source: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2025 Nov 26; Vol. 18 (12). Date of Electronic Publication: 2025 Nov 26.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print) Linking ISSN: 14248247 NLM ISO Abbreviation: Pharmaceuticals (Basel) Subsets: PubMed not MEDLINE
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  Data: Synthesis of Novel Arylhydrazones Bearing 8-Trifluoromethyl Quinoline: Crystal Insights, Larvicidal Activity, ADMET Predictions, and Molecular Docking Studies.
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