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LDLR variant classification through activity-normalized prime editing screening.

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Title: LDLR variant classification through activity-normalized prime editing screening.
Authors: Zhou PJ; Brigham and Women's Hospital Department of Medicine, Division of Genetics, Boston, MA, USA., Velimirovic M; Brigham and Women's Hospital Department of Medicine, Division of Genetics, Boston, MA, USA.; Département de Médecine Moléculaire, Faculté de Médecine, Université Laval, Québec City, QC, Canada., Yu T; Brigham and Women's Hospital Department of Medicine, Division of Genetics, Boston, MA, USA., Gligorovski V; Laboratory of the Physics of Biological Systems, Institute of Physics, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland., Mathis N; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Zhao J; Translational Neuroscience Center, Boston Children's Hospital, Boston, MA, USA., Phan QV; Brigham and Women's Hospital Department of Medicine, Division of Genetics, Boston, MA, USA., Vogd F; Brigham and Women's Hospital Department of Medicine, Division of Genetics, Boston, MA, USA., Ryu J; Molecular Pathology Unit, Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Pan Q; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia.; Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia., Tyagi A; Brigham and Women's Hospital Department of Medicine, Division of Genetics, Boston, MA, USA., Ascher DB; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia.; Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia., Schwank G; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Pinello L; Molecular Pathology Unit, Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Cassa CA; Brigham and Women's Hospital Department of Medicine, Division of Genetics, Boston, MA, USA., Sherwood RI; Brigham and Women's Hospital Department of Medicine, Division of Genetics, Boston, MA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Dec 18. Date of Electronic Publication: 2025 Dec 18.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Zhou+PJ%22">Zhou PJ</searchLink>; Brigham and Women's Hospital Department of Medicine, Division of Genetics, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Velimirovic+M%22">Velimirovic M</searchLink>; Brigham and Women's Hospital Department of Medicine, Division of Genetics, Boston, MA, USA.; Département de Médecine Moléculaire, Faculté de Médecine, Université Laval, Québec City, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Yu+T%22">Yu T</searchLink>; Brigham and Women's Hospital Department of Medicine, Division of Genetics, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gligorovski+V%22">Gligorovski V</searchLink>; Laboratory of the Physics of Biological Systems, Institute of Physics, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mathis+N%22">Mathis N</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Zhao+J%22">Zhao J</searchLink>; Translational Neuroscience Center, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Phan+QV%22">Phan QV</searchLink>; Brigham and Women's Hospital Department of Medicine, Division of Genetics, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Vogd+F%22">Vogd F</searchLink>; Brigham and Women's Hospital Department of Medicine, Division of Genetics, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ryu+J%22">Ryu J</searchLink>; Molecular Pathology Unit, Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pan+Q%22">Pan Q</searchLink>; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia.; Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Tyagi+A%22">Tyagi A</searchLink>; Brigham and Women's Hospital Department of Medicine, Division of Genetics, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ascher+DB%22">Ascher DB</searchLink>; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia.; Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Schwank+G%22">Schwank G</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pinello+L%22">Pinello L</searchLink>; Molecular Pathology Unit, Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cassa+CA%22">Cassa CA</searchLink>; Brigham and Women's Hospital Department of Medicine, Division of Genetics, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sherwood+RI%22">Sherwood RI</searchLink>; Brigham and Women's Hospital Department of Medicine, Division of Genetics, Boston, MA, USA.
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              Text: 2025 Dec 18
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