A novel hierarchical framework elucidating regional differences in α-synuclein and tau co-pathology in military veterans with parkinsonism.

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Title: A novel hierarchical framework elucidating regional differences in α-synuclein and tau co-pathology in military veterans with parkinsonism.
Authors: Flores Almazan VG; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Laborc KF; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States., De Sanctis C; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Thorn EL; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Goldstein A; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Cervera A; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Quintana Mora DF; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Neurology, James J. Peters Veterans Affairs Medical Center, Bronx, NY, United States.; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Mendez Y; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Neurology, James J. Peters Veterans Affairs Medical Center, Bronx, NY, United States.; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States., McGoldrick AC; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Neurology, James J. Peters Veterans Affairs Medical Center, Bronx, NY, United States.; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Chiu LY; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Hossain QI; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States., McQuillan S; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Lind-Watson K; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Walker JM; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, TX, United States., Walker RH; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Neurology, James J. Peters Veterans Affairs Medical Center, Bronx, NY, United States.; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Nirenberg MJ; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Neurology, James J. Peters Veterans Affairs Medical Center, Bronx, NY, United States.; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Crary JF; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Department of Artificial Intelligence & Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Source: Journal of neuropathology and experimental neurology [J Neuropathol Exp Neurol] 2026 Jun 01; Vol. 85 (6), pp. 525-536.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 2985192R Publication Model: Print Cited Medium: Internet ISSN: 1554-6578 (Electronic) Linking ISSN: 00223069 NLM ISO Abbreviation: J Neuropathol Exp Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1554-6578
DOI:10.1093/jnen/nlaf137