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Assessing PARP trapping dynamics in ovarian cancer using a CRISPR-engineered FRET biosensor.

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Title: Assessing PARP trapping dynamics in ovarian cancer using a CRISPR-engineered FRET biosensor.
Authors: Marks D; Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK; Francis Crick Institute, London NW1 1AT, UK; Department of Physics, Imperial College London, London SW7 2AZ, UK., Garcia E; Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK; Francis Crick Institute, London NW1 1AT, UK; Department of Physics, Imperial College London, London SW7 2AZ, UK., Kumar S; Francis Crick Institute, London NW1 1AT, UK; Department of Physics, Imperial College London, London SW7 2AZ, UK., Tyson K; Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK., Koch C; Department of Chemistry, Imperial College London, London W12 0BZ, UK., Ivanov AP; Department of Chemistry, Imperial College London, London W12 0BZ, UK., Edel JB; Department of Chemistry, Imperial College London, London W12 0BZ, UK., Mirza HB; Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK., Flanagan W; Francis Crick Institute, London NW1 1AT, UK; Department of Physics, Imperial College London, London SW7 2AZ, UK., Dunsby C; Francis Crick Institute, London NW1 1AT, UK; Department of Physics, Imperial College London, London SW7 2AZ, UK., French PMW; Francis Crick Institute, London NW1 1AT, UK; Department of Physics, Imperial College London, London SW7 2AZ, UK., McNeish IA; Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK. Electronic address: i.mcneish@imperial.ac.uk.
Source: Cell reports methods [Cell Rep Methods] 2026 Jan 26; Vol. 6 (1), pp. 101270. Date of Electronic Publication: 2025 Dec 30.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 9918227360606676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2667-2375 (Electronic) Linking ISSN: 26672375 NLM ISO Abbreviation: Cell Rep Methods Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Marks+D%22">Marks D</searchLink>; Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK; Francis Crick Institute, London NW1 1AT, UK; Department of Physics, Imperial College London, London SW7 2AZ, UK.<br /><searchLink fieldCode="AU" term="%22Garcia+E%22">Garcia E</searchLink>; Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK; Francis Crick Institute, London NW1 1AT, UK; Department of Physics, Imperial College London, London SW7 2AZ, UK.<br /><searchLink fieldCode="AU" term="%22Kumar+S%22">Kumar S</searchLink>; Francis Crick Institute, London NW1 1AT, UK; Department of Physics, Imperial College London, London SW7 2AZ, UK.<br /><searchLink fieldCode="AU" term="%22Tyson+K%22">Tyson K</searchLink>; Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK.<br /><searchLink fieldCode="AU" term="%22Koch+C%22">Koch C</searchLink>; Department of Chemistry, Imperial College London, London W12 0BZ, UK.<br /><searchLink fieldCode="AU" term="%22Ivanov+AP%22">Ivanov AP</searchLink>; Department of Chemistry, Imperial College London, London W12 0BZ, UK.<br /><searchLink fieldCode="AU" term="%22Edel+JB%22">Edel JB</searchLink>; Department of Chemistry, Imperial College London, London W12 0BZ, UK.<br /><searchLink fieldCode="AU" term="%22Mirza+HB%22">Mirza HB</searchLink>; Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK.<br /><searchLink fieldCode="AU" term="%22Flanagan+W%22">Flanagan W</searchLink>; Francis Crick Institute, London NW1 1AT, UK; Department of Physics, Imperial College London, London SW7 2AZ, UK.<br /><searchLink fieldCode="AU" term="%22Dunsby+C%22">Dunsby C</searchLink>; Francis Crick Institute, London NW1 1AT, UK; Department of Physics, Imperial College London, London SW7 2AZ, UK.<br /><searchLink fieldCode="AU" term="%22French+PMW%22">French PMW</searchLink>; Francis Crick Institute, London NW1 1AT, UK; Department of Physics, Imperial College London, London SW7 2AZ, UK.<br /><searchLink fieldCode="AU" term="%22McNeish+IA%22">McNeish IA</searchLink>; Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK. Electronic address: i.mcneish@imperial.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%229918227360606676%22">Cell reports methods</searchLink> [Cell Rep Methods] 2026 Jan 26; Vol. 6 (1), pp. 101270. <i>Date of Electronic Publication: </i>2025 Dec 30.
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