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4R-tau seeding activity reveals molecular subtypes in progressive supranuclear palsy.

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Title: 4R-tau seeding activity reveals molecular subtypes in progressive supranuclear palsy.
Authors: Martinez-Valbuena I; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada., Lee S; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Santamaria E; Clinical Neuroproteomics Unit, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdisNa), Pamplona, Navarra, Spain., Fernández-Irigoyen J; Clinical Neuroproteomics Unit, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdisNa), Pamplona, Navarra, Spain., Forrest SL; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.; Dementia Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia., Zampar S; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada., Li J; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada., Tanaka H; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Couto B; Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada.; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada.; Institute of Cognitive and Translational Neuroscience (INCyT-INECO), Buenos Aires, Argentina., Gil D Reyes N; Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada.; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada., Qamar SH; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Karakani AM; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada., Kim A; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Senkevich K; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada., Rogaeva E; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada., Fox SH; Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada., Tartaglia MC; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.; University Health Network Memory Clinic, Toronto Western Hospital, Toronto, ON, Canada.; Department of Medicine, University of Toronto, Toronto, ON, Canada., Visanji NP; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada., Ingelsson M; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; University Health Network Memory Clinic, Toronto Western Hospital, Toronto, ON, Canada.; Department of Medicine, University of Toronto, Toronto, ON, Canada.; Department of Public Health and Caring Sciences, Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden., Andrews T; Department of Biochemistry, University of Western Ontario, London, ON, Canada.; Department of Computer Science, University of Western Ontario, London, ON, Canada., Lang AE; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada., Kovacs GG; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada. gabor.kovacs@uhn.ca.; Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada. gabor.kovacs@uhn.ca.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada. gabor.kovacs@uhn.ca.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. gabor.kovacs@uhn.ca.; Dementia Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia. gabor.kovacs@uhn.ca.; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada. gabor.kovacs@uhn.ca.
Source: Nature communications [Nat Commun] 2025 Dec 31; Vol. 17 (1), pp. 1006. Date of Electronic Publication: 2025 Dec 31.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Martinez-Valbuena+I%22">Martinez-Valbuena I</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Lee+S%22">Lee S</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Santamaria+E%22">Santamaria E</searchLink>; Clinical Neuroproteomics Unit, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdisNa), Pamplona, Navarra, Spain.<br /><searchLink fieldCode="AU" term="%22Fernández-Irigoyen+J%22">Fernández-Irigoyen J</searchLink>; Clinical Neuroproteomics Unit, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdisNa), Pamplona, Navarra, Spain.<br /><searchLink fieldCode="AU" term="%22Forrest+SL%22">Forrest SL</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.; Dementia Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Zampar+S%22">Zampar S</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Tanaka+H%22">Tanaka H</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Couto+B%22">Couto B</searchLink>; Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada.; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada.; Institute of Cognitive and Translational Neuroscience (INCyT-INECO), Buenos Aires, Argentina.<br /><searchLink fieldCode="AU" term="%22Gil+D+Reyes+N%22">Gil D Reyes N</searchLink>; Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada.; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Qamar+SH%22">Qamar SH</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Karakani+AM%22">Karakani AM</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Kim+A%22">Kim A</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Senkevich+K%22">Senkevich K</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Rogaeva+E%22">Rogaeva E</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Fox+SH%22">Fox SH</searchLink>; Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Tartaglia+MC%22">Tartaglia MC</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.; University Health Network Memory Clinic, Toronto Western Hospital, Toronto, ON, Canada.; Department of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Visanji+NP%22">Visanji NP</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Ingelsson+M%22">Ingelsson M</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; University Health Network Memory Clinic, Toronto Western Hospital, Toronto, ON, Canada.; Department of Medicine, University of Toronto, Toronto, ON, Canada.; Department of Public Health and Caring Sciences, Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Andrews+T%22">Andrews T</searchLink>; Department of Biochemistry, University of Western Ontario, London, ON, Canada.; Department of Computer Science, University of Western Ontario, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Lang+AE%22">Lang AE</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Kovacs+GG%22">Kovacs GG</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada. gabor.kovacs@uhn.ca.; Rossy Progressive Supranuclear Palsy Centre, Toronto Western Hospital, Toronto, ON, Canada. gabor.kovacs@uhn.ca.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada. gabor.kovacs@uhn.ca.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. gabor.kovacs@uhn.ca.; Dementia Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia. gabor.kovacs@uhn.ca.; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada. gabor.kovacs@uhn.ca.
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