NLRP3 facilitates α-synuclein-induced dopaminergic neuronal senescence in a mouse model of Parkinson's disease through SATB1/DNA damage/p21 signaling pathway.
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| Title: | NLRP3 facilitates α-synuclein-induced dopaminergic neuronal senescence in a mouse model of Parkinson's disease through SATB1/DNA damage/p21 signaling pathway. |
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| Authors: | Chen LL; Institute of Brain Science and Disease, Qingdao University, Qingdao, 266071, China. leileichen2019@qdu.edu.cn.; Shandong Provincial Neuroscience Research Center, Qingdao University, Qingdao, 266071, China. leileichen2019@qdu.edu.cn.; Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Qingdao University, Qingdao, 266071, China. leileichen2019@qdu.edu.cn.; Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Qingdao University, Qingdao, 266071, China. leileichen2019@qdu.edu.cn., Shen QQ; Institute of Brain Science and Disease, Qingdao University, Qingdao, 266071, China.; Shandong Provincial Neuroscience Research Center, Qingdao University, Qingdao, 266071, China.; Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Qingdao University, Qingdao, 266071, China.; Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Qingdao University, Qingdao, 266071, China.; Medical School, Linyi University, Linyi, 276000, China., Sun LP; Institute of Brain Science and Disease, Qingdao University, Qingdao, 266071, China.; Shandong Provincial Neuroscience Research Center, Qingdao University, Qingdao, 266071, China.; Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Qingdao University, Qingdao, 266071, China.; Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Qingdao University, Qingdao, 266071, China., Song YX; Institute of Brain Science and Disease, Qingdao University, Qingdao, 266071, China.; Shandong Provincial Neuroscience Research Center, Qingdao University, Qingdao, 266071, China.; Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Qingdao University, Qingdao, 266071, China.; Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Qingdao University, Qingdao, 266071, China., Jia WT; Institute of Brain Science and Disease, Qingdao University, Qingdao, 266071, China.; Shandong Provincial Neuroscience Research Center, Qingdao University, Qingdao, 266071, China.; Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Qingdao University, Qingdao, 266071, China.; Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Qingdao University, Qingdao, 266071, China., Qu L; Institute of Brain Science and Disease, Qingdao University, Qingdao, 266071, China.; Shandong Provincial Neuroscience Research Center, Qingdao University, Qingdao, 266071, China.; Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Qingdao University, Qingdao, 266071, China.; Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Qingdao University, Qingdao, 266071, China., Xie JX; Institute of Brain Science and Disease, Qingdao University, Qingdao, 266071, China. jxiaxie@163.com.; Shandong Provincial Neuroscience Research Center, Qingdao University, Qingdao, 266071, China. jxiaxie@163.com.; Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Qingdao University, Qingdao, 266071, China. jxiaxie@163.com.; Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Qingdao University, Qingdao, 266071, China. jxiaxie@163.com. |
| Source: | Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Apr; Vol. 47 (4), pp. 860-875. Date of Electronic Publication: 2026 Jan 01. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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