Native C3 is activated without proteolytic cleavage by transformation to C3(H2O) on phospholipid-scrambled cell membranes. - Eikrem D; Manivel VA; Whittaker J; Hamad OA; Mohlin C; Adler A; Dührkop C; Ebert R; Teramura Y; Ekdahl KN; Fromell K; Nilsson B (Frontiers in immunology, 2025)