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Development of a novel 18F-labeled reversible-binding radioligand for imaging monoacylglycerol lipase with positron emission tomography.

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Title: Development of a novel 18F-labeled reversible-binding radioligand for imaging monoacylglycerol lipase with positron emission tomography.
Authors: Rong J; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA., Zhao C; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA., Chaudhary AF; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA., Ware T; The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Van RS; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA., Li Y; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA., Calderon Leon ER; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA., Dang V; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA., Chen J; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA., Xiao Z; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA., Zhou X; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA., Zhang W; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA., Bi C; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA., Zhang K; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA., Patel JS; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA., Shao Y; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA., Ran C; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA., Collin L; F. Hoffmann-La Roche Ltd. Roche. Innovation Center Basel, Switzerland by Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, Basel 4070, Switzerland., Haider A; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA.; F. Hoffmann-La Roche Ltd. Roche. Innovation Center Basel, Switzerland by Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, Basel 4070, Switzerland., Cravatt BF; The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Liang SH; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA.
Source: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2025 Dec; Vol. 15 (12), pp. 6714-6726. Date of Electronic Publication: 2025 Jun 03.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101600560 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2211-3835 (Print) Linking ISSN: 22113835 NLM ISO Abbreviation: Acta Pharm Sin B Subsets: PubMed not MEDLINE
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  Data: Development of a novel <superscript>18</superscript>F-labeled reversible-binding radioligand for imaging monoacylglycerol lipase with positron emission tomography.
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  Data: <searchLink fieldCode="AU" term="%22Rong+J%22">Rong J</searchLink>; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+C%22">Zhao C</searchLink>; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Chaudhary+AF%22">Chaudhary AF</searchLink>; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Ware+T%22">Ware T</searchLink>; The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Van+RS%22">Van RS</searchLink>; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Calderon+Leon+ER%22">Calderon Leon ER</searchLink>; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA.<br /><searchLink fieldCode="AU" term="%22Dang+V%22">Dang V</searchLink>; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Xiao+Z%22">Xiao Z</searchLink>; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Bi+C%22">Bi C</searchLink>; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+K%22">Zhang K</searchLink>; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Patel+JS%22">Patel JS</searchLink>; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Shao+Y%22">Shao Y</searchLink>; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA.<br /><searchLink fieldCode="AU" term="%22Ran+C%22">Ran C</searchLink>; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Collin+L%22">Collin L</searchLink>; F. Hoffmann-La Roche Ltd. Roche. Innovation Center Basel, Switzerland by Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, Basel 4070, Switzerland.<br /><searchLink fieldCode="AU" term="%22Haider+A%22">Haider A</searchLink>; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA.; F. Hoffmann-La Roche Ltd. Roche. Innovation Center Basel, Switzerland by Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, Basel 4070, Switzerland.<br /><searchLink fieldCode="AU" term="%22Cravatt+BF%22">Cravatt BF</searchLink>; The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Liang+SH%22">Liang SH</searchLink>; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA.
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  Data: <searchLink fieldCode="JN" term="%22101600560%22">Acta pharmaceutica Sinica. B</searchLink> [Acta Pharm Sin B] 2025 Dec; Vol. 15 (12), pp. 6714-6726. <i>Date of Electronic Publication: </i>2025 Jun 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101600560 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2211-3835 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222113835%22">22113835 </searchLink><i>NLM ISO Abbreviation: </i>Acta Pharm Sin B <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1016/j.apsb.2025.05.041
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              Text: 2025 Dec
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