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Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice.

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Title: Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice.
Authors: Dorstyn L; Centre for Cancer Biology, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia.; College of Health, Adelaide University, Adelaide, SA 5005, Australia., Lim Y; Centre for Cancer Biology, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia.; College of Health, Adelaide University, Adelaide, SA 5005, Australia., Scanlan J; Centre for Cancer Biology, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia.; College of Health, Adelaide University, Adelaide, SA 5005, Australia., McLennan E; Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, Parkville, VIC 3052, Australia., De Bellis D; Centre for Cancer Biology, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia., Katschner M; Centre for Cancer Biology, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia.; College of Health, Adelaide University, Adelaide, SA 5005, Australia., Finnie J; Adelaide Medical School, The University of Adelaide, North Terrace, Adelaide, SA 5005, Australia., Emery-Corbin S; Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; University of Melbourne, Melbourne, VIC 3010, Australia., Yousef J; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; University of Melbourne, Melbourne, VIC 3010, Australia., Dagley LF; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; University of Melbourne, Melbourne, VIC 3010, Australia., Kok CH; Centre for Cancer Biology, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia.; Adelaide Medical School, The University of Adelaide, North Terrace, Adelaide, SA 5005, Australia.; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA 5000, Australia., Shah SS; Centre for Cancer Biology, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia.; College of Health, Adelaide University, Adelaide, SA 5005, Australia., Takahashi C; Cancer Research Institute, Kanazawa University, Kanazawa, Japan., Febbraio MA; Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, Parkville, VIC 3052, Australia., Kumar S; Centre for Cancer Biology, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia.; College of Health, Adelaide University, Adelaide, SA 5005, Australia.; Adelaide Medical School, The University of Adelaide, North Terrace, Adelaide, SA 5005, Australia.
Source: Science advances [Sci Adv] 2026 Jan 02; Vol. 12 (1), pp. eaeb2571. Date of Electronic Publication: 2026 Jan 01.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice.
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  Data: <searchLink fieldCode="AU" term="%22Dorstyn+L%22">Dorstyn L</searchLink>; Centre for Cancer Biology, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia.; College of Health, Adelaide University, Adelaide, SA 5005, Australia.<br /><searchLink fieldCode="AU" term="%22Lim+Y%22">Lim Y</searchLink>; Centre for Cancer Biology, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia.; College of Health, Adelaide University, Adelaide, SA 5005, Australia.<br /><searchLink fieldCode="AU" term="%22Scanlan+J%22">Scanlan J</searchLink>; Centre for Cancer Biology, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia.; College of Health, Adelaide University, Adelaide, SA 5005, Australia.<br /><searchLink fieldCode="AU" term="%22McLennan+E%22">McLennan E</searchLink>; Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, Parkville, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22De+Bellis+D%22">De Bellis D</searchLink>; Centre for Cancer Biology, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia.<br /><searchLink fieldCode="AU" term="%22Katschner+M%22">Katschner M</searchLink>; Centre for Cancer Biology, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia.; College of Health, Adelaide University, Adelaide, SA 5005, Australia.<br /><searchLink fieldCode="AU" term="%22Finnie+J%22">Finnie J</searchLink>; Adelaide Medical School, The University of Adelaide, North Terrace, Adelaide, SA 5005, Australia.<br /><searchLink fieldCode="AU" term="%22Emery-Corbin+S%22">Emery-Corbin S</searchLink>; Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; University of Melbourne, Melbourne, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Yousef+J%22">Yousef J</searchLink>; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; University of Melbourne, Melbourne, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Dagley+LF%22">Dagley LF</searchLink>; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.; University of Melbourne, Melbourne, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Kok+CH%22">Kok CH</searchLink>; Centre for Cancer Biology, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia.; Adelaide Medical School, The University of Adelaide, North Terrace, Adelaide, SA 5005, Australia.; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA 5000, Australia.<br /><searchLink fieldCode="AU" term="%22Shah+SS%22">Shah SS</searchLink>; Centre for Cancer Biology, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia.; College of Health, Adelaide University, Adelaide, SA 5005, Australia.<br /><searchLink fieldCode="AU" term="%22Takahashi+C%22">Takahashi C</searchLink>; Cancer Research Institute, Kanazawa University, Kanazawa, Japan.<br /><searchLink fieldCode="AU" term="%22Febbraio+MA%22">Febbraio MA</searchLink>; Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, Parkville, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Kumar+S%22">Kumar S</searchLink>; Centre for Cancer Biology, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia.; College of Health, Adelaide University, Adelaide, SA 5005, Australia.; Adelaide Medical School, The University of Adelaide, North Terrace, Adelaide, SA 5005, Australia.
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