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HLA-Shuttle: A system for enhancing antigen presentation in immunologically cold tumors.

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Title: HLA-Shuttle: A system for enhancing antigen presentation in immunologically cold tumors.
Authors: Hwang D; Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Erdman MC; Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Adhikari S; Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Howard Hughes Medical Institute and Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Pantula R; Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Epstein K; Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Cancer Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Li P; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Costabile F; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA., Rotsides P; Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Wang CS; Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Immunology Graduate Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Sun SM; Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Cancer Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Fazelinia H; Proteomics Core Facility, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Spruce LA; Proteomics Core Facility, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Fugmann T; Alithea Biotechnology, Freiburg im Breisgau, Germany., Rrustemi T; Alithea Biotechnology, Freiburg im Breisgau, Germany., Soh WT; Alithea Biotechnology, Freiburg im Breisgau, Germany., Farrel A; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Want MY; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Facciabene A; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA., Mir M; Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Howard Hughes Medical Institute and Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Maris JM; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Sgourakis NG; Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Source: Science advances [Sci Adv] 2026 Jan 02; Vol. 12 (1), pp. eaeb0821. Date of Electronic Publication: 2026 Jan 01.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: HLA-Shuttle: A system for enhancing antigen presentation in immunologically cold tumors.
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  Data: <searchLink fieldCode="AU" term="%22Hwang+D%22">Hwang D</searchLink>; Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Erdman+MC%22">Erdman MC</searchLink>; Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Adhikari+S%22">Adhikari S</searchLink>; Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Howard Hughes Medical Institute and Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Pantula+R%22">Pantula R</searchLink>; Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Epstein+K%22">Epstein K</searchLink>; Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Cancer Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Li+P%22">Li P</searchLink>; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Costabile+F%22">Costabile F</searchLink>; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Rotsides+P%22">Rotsides P</searchLink>; Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Wang+CS%22">Wang CS</searchLink>; Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Immunology Graduate Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Sun+SM%22">Sun SM</searchLink>; Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Cancer Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Fazelinia+H%22">Fazelinia H</searchLink>; Proteomics Core Facility, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Spruce+LA%22">Spruce LA</searchLink>; Proteomics Core Facility, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Fugmann+T%22">Fugmann T</searchLink>; Alithea Biotechnology, Freiburg im Breisgau, Germany.<br /><searchLink fieldCode="AU" term="%22Rrustemi+T%22">Rrustemi T</searchLink>; Alithea Biotechnology, Freiburg im Breisgau, Germany.<br /><searchLink fieldCode="AU" term="%22Soh+WT%22">Soh WT</searchLink>; Alithea Biotechnology, Freiburg im Breisgau, Germany.<br /><searchLink fieldCode="AU" term="%22Farrel+A%22">Farrel A</searchLink>; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Want+MY%22">Want MY</searchLink>; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Facciabene+A%22">Facciabene A</searchLink>; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Mir+M%22">Mir M</searchLink>; Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Howard Hughes Medical Institute and Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Maris+JM%22">Maris JM</searchLink>; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Sgourakis+NG%22">Sgourakis NG</searchLink>; Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
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  Data: <searchLink fieldCode="JN" term="%22101653440%22">Science advances</searchLink> [Sci Adv] 2026 Jan 02; Vol. 12 (1), pp. eaeb0821. <i>Date of Electronic Publication: </i>2026 Jan 01.
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