Immune signature-based uncoupling of checkpoint inhibitor efficacy and toxicity.

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Bibliographic Details
Title: Immune signature-based uncoupling of checkpoint inhibitor efficacy and toxicity.
Authors: Lucas MW; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Burton EM; Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Dimitriadis P; Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Huang AC; Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Long GV; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia; Department of Medical Oncology, Royal North Shore and Mater Hospitals, Sydney, NSW, Australia., Mitchell TC; Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Amaria RN; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Blank CU; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands; Department of Hematology and Medical Oncology, University Clinic Regensburg, Regensburg, Germany; Division of Melanoma and Sarcoma, European Institute of Oncology, Milano, Italy. Electronic address: c.blank@nki.nl.
Source: Immunity [Immunity] 2026 Jan 13; Vol. 59 (1), pp. 29-33.e2. Date of Electronic Publication: 2025 Dec 31.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4180
DOI:10.1016/j.immuni.2025.11.021