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Immune signature-based uncoupling of checkpoint inhibitor efficacy and toxicity.

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Title: Immune signature-based uncoupling of checkpoint inhibitor efficacy and toxicity.
Authors: Lucas MW; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Burton EM; Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Dimitriadis P; Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Huang AC; Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Long GV; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia; Department of Medical Oncology, Royal North Shore and Mater Hospitals, Sydney, NSW, Australia., Mitchell TC; Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Amaria RN; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Blank CU; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands; Department of Hematology and Medical Oncology, University Clinic Regensburg, Regensburg, Germany; Division of Melanoma and Sarcoma, European Institute of Oncology, Milano, Italy. Electronic address: c.blank@nki.nl.
Source: Immunity [Immunity] 2026 Jan 13; Vol. 59 (1), pp. 29-33.e2. Date of Electronic Publication: 2025 Dec 31.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Immune signature-based uncoupling of checkpoint inhibitor efficacy and toxicity.
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  Data: <searchLink fieldCode="AU" term="%22Lucas+MW%22">Lucas MW</searchLink>; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Burton+EM%22">Burton EM</searchLink>; Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Dimitriadis+P%22">Dimitriadis P</searchLink>; Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Huang+AC%22">Huang AC</searchLink>; Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Long+GV%22">Long GV</searchLink>; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia; Department of Medical Oncology, Royal North Shore and Mater Hospitals, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Mitchell+TC%22">Mitchell TC</searchLink>; Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Amaria+RN%22">Amaria RN</searchLink>; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Blank+CU%22">Blank CU</searchLink>; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands; Department of Hematology and Medical Oncology, University Clinic Regensburg, Regensburg, Germany; Division of Melanoma and Sarcoma, European Institute of Oncology, Milano, Italy. Electronic address: c.blank@nki.nl.
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  Data: <searchLink fieldCode="JN" term="%229432918%22">Immunity</searchLink> [Immunity] 2026 Jan 13; Vol. 59 (1), pp. 29-33.e2. <i>Date of Electronic Publication: </i>2025 Dec 31.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9432918 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-4180 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210747613%22">10747613 </searchLink><i>NLM ISO Abbreviation: </i>Immunity <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.immuni.2025.11.021
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        Text: English
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              Text: 2026 Jan 13
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