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Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi.

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Title: Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi.
Authors: Chen X; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada., Duan HD; Department of Structural Biology, Van Andel Institute, Grand Rapids, MI 49503, USA., Hoy MJ; Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA., Koteva K; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada., Spitzer M; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada., Guitor AK; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada., Puumala E; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada., Fiebig AA; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada., Hu G; Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada., Yiu B; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada., Chou S; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada., Bian Z; Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA., Choi Y; Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA., Guo ABY; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada., Wang W; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada., Sun S; Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA., Robbins N; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada., Averette AF; Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA., Cook MA; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada., Truant R; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada., MacNeil LT; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada., Brown ED; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada., Kronstad JW; Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada., Coombes BK; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada., Cowen LE; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada., Heitman J; Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA., Li H; Department of Structural Biology, Van Andel Institute, Grand Rapids, MI 49503, USA. Electronic address: huilin.li@vai.org., Wright GD; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada. Electronic address: wrightge@mcmaster.ca.
Source: Cell [Cell] 2026 Jan 22; Vol. 189 (2), pp. 620-639.e28. Date of Electronic Publication: 2025 Dec 31.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
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  Data: Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi.
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  Data: <searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Duan+HD%22">Duan HD</searchLink>; Department of Structural Biology, Van Andel Institute, Grand Rapids, MI 49503, USA.<br /><searchLink fieldCode="AU" term="%22Hoy+MJ%22">Hoy MJ</searchLink>; Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Koteva+K%22">Koteva K</searchLink>; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Spitzer+M%22">Spitzer M</searchLink>; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Guitor+AK%22">Guitor AK</searchLink>; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Puumala+E%22">Puumala E</searchLink>; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada.<br /><searchLink fieldCode="AU" term="%22Fiebig+AA%22">Fiebig AA</searchLink>; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Hu+G%22">Hu G</searchLink>; Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Yiu+B%22">Yiu B</searchLink>; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada.<br /><searchLink fieldCode="AU" term="%22Chou+S%22">Chou S</searchLink>; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Bian+Z%22">Bian Z</searchLink>; Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Choi+Y%22">Choi Y</searchLink>; Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Guo+ABY%22">Guo ABY</searchLink>; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Sun+S%22">Sun S</searchLink>; Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Robbins+N%22">Robbins N</searchLink>; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada.<br /><searchLink fieldCode="AU" term="%22Averette+AF%22">Averette AF</searchLink>; Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Cook+MA%22">Cook MA</searchLink>; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Truant+R%22">Truant R</searchLink>; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada.<br /><searchLink fieldCode="AU" term="%22MacNeil+LT%22">MacNeil LT</searchLink>; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada.<br /><searchLink fieldCode="AU" term="%22Brown+ED%22">Brown ED</searchLink>; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Kronstad+JW%22">Kronstad JW</searchLink>; Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Coombes+BK%22">Coombes BK</searchLink>; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Cowen+LE%22">Cowen LE</searchLink>; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada.<br /><searchLink fieldCode="AU" term="%22Heitman+J%22">Heitman J</searchLink>; Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Department of Structural Biology, Van Andel Institute, Grand Rapids, MI 49503, USA. Electronic address: huilin.li@vai.org.<br /><searchLink fieldCode="AU" term="%22Wright+GD%22">Wright GD</searchLink>; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada. Electronic address: wrightge@mcmaster.ca.
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  Data: <searchLink fieldCode="JN" term="%220413066%22">Cell</searchLink> [Cell] 2026 Jan 22; Vol. 189 (2), pp. 620-639.e28. <i>Date of Electronic Publication: </i>2025 Dec 31.
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