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Plasma Aβ42/40 predicts progression from Aβ-amyloid negative to positive PET scans.

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Title: Plasma Aβ42/40 predicts progression from Aβ-amyloid negative to positive PET scans.
Authors: Feizpour A; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, VIC, 3052, Australia; Department of Molecular Imaging & Therapy, Austin Health, 145 Studley Road, Heidelberg, VIC, 3084, Australia. Electronic address: azadeh.feizpour@florey.edu.au., Doré V; Department of Molecular Imaging & Therapy, Austin Health, 145 Studley Road, Heidelberg, VIC, 3084, Australia; The Australian e-Health Research Centre, CSIRO, 351 Royal Parade, Parkville, VIC, 3052, Australia., Bourgeat P; The Australian e-Health Research Centre, CSIRO, 296 Herston Rd, Herston, Qld, 4029, Australia., Doecke JD; The Australian e-Health Research Centre, CSIRO, 296 Herston Rd, Herston, Qld, 4029, Australia., Canovas R; The Australian e-Health Research Centre, CSIRO, 351 Royal Parade, Parkville, VIC, 3052, Australia., Laws SM; Centre for Precision Health, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia; Curtin Medical School, Curtin University, Kent Street, Bentley, WA, 6102, Australia., Porter T; Centre for Precision Health, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia; Curtin Medical School, Curtin University, Kent Street, Bentley, WA, 6102, Australia., Huang K; Department of Molecular Imaging & Therapy, Austin Health, 145 Studley Road, Heidelberg, VIC, 3084, Australia., Fowler C; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, VIC, 3052, Australia., Martins RN; Australian Alzheimer's Research Foundation, Nedlands, WA, 6009, Australia., Maruff P; Cogstate Ltd, 161 Collins St, Melbourne, VIC, 3000, Australia., Sohrabi HR; Centre for Healthy Ageing, Health Futures Institute, Murdoch University, WA, 6150, Australia; School of Psychology, Murdoch University, WA, 6150, Australia., Weiner MW; Department of Radiology, University of California at San Francisco, San Francisco, 505 Parnassus Avenue, San Francisco, CA, 94143, USA., Morris JC; Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA; Charles F. and Joanne Knight Alzheimer Disease Research Center (Knight ADRC), Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA., Benzinger TLS; Charles F. and Joanne Knight Alzheimer Disease Research Center (Knight ADRC), Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA; Department of Radiology, Washington University in St. Louis, 510 South Kingshighway Boulevard, St. Louis, MO, 63110, USA., Schindler SE; Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA; Charles F. and Joanne Knight Alzheimer Disease Research Center (Knight ADRC), Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA., Bateman RJ; Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA; Charles F. and Joanne Knight Alzheimer Disease Research Center (Knight ADRC), Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA; Tracy Family SILQ Center, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA., Li Y; Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA., Vitaliy O; Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA; Tracy Family SILQ Center, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA., Ward L; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, VIC, 3052, Australia., Mejan-Fripp J; The Australian e-Health Research Centre, CSIRO, 296 Herston Rd, Herston, Qld, 4029, Australia., Masters CL; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, VIC, 3052, Australia., Villemagne VL; Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, USA., Rowe CC; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, VIC, 3052, Australia; Department of Molecular Imaging & Therapy, Austin Health, 145 Studley Road, Heidelberg, VIC, 3084, Australia. Electronic address: christopher.rowe@austin.org.au.
Corporate Authors: ADOPIC Consortium (AIBL, ADNI, OASIS)
Source: The journal of prevention of Alzheimer's disease [J Prev Alzheimers Dis] 2026 Feb; Vol. 13 (2), pp. 100455. Date of Electronic Publication: 2026 Jan 01.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101638820 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2426-0266 (Electronic) Linking ISSN: 22745807 NLM ISO Abbreviation: J Prev Alzheimers Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Plasma Aβ42/40 predicts progression from Aβ-amyloid negative to positive PET scans.
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  Data: <searchLink fieldCode="AU" term="%22Feizpour+A%22">Feizpour A</searchLink>; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, VIC, 3052, Australia; Department of Molecular Imaging & Therapy, Austin Health, 145 Studley Road, Heidelberg, VIC, 3084, Australia. Electronic address: azadeh.feizpour@florey.edu.au.<br /><searchLink fieldCode="AU" term="%22Doré+V%22">Doré V</searchLink>; Department of Molecular Imaging & Therapy, Austin Health, 145 Studley Road, Heidelberg, VIC, 3084, Australia; The Australian e-Health Research Centre, CSIRO, 351 Royal Parade, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Bourgeat+P%22">Bourgeat P</searchLink>; The Australian e-Health Research Centre, CSIRO, 296 Herston Rd, Herston, Qld, 4029, Australia.<br /><searchLink fieldCode="AU" term="%22Doecke+JD%22">Doecke JD</searchLink>; The Australian e-Health Research Centre, CSIRO, 296 Herston Rd, Herston, Qld, 4029, Australia.<br /><searchLink fieldCode="AU" term="%22Canovas+R%22">Canovas R</searchLink>; The Australian e-Health Research Centre, CSIRO, 351 Royal Parade, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Laws+SM%22">Laws SM</searchLink>; Centre for Precision Health, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia; Curtin Medical School, Curtin University, Kent Street, Bentley, WA, 6102, Australia.<br /><searchLink fieldCode="AU" term="%22Porter+T%22">Porter T</searchLink>; Centre for Precision Health, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia; Curtin Medical School, Curtin University, Kent Street, Bentley, WA, 6102, Australia.<br /><searchLink fieldCode="AU" term="%22Huang+K%22">Huang K</searchLink>; Department of Molecular Imaging & Therapy, Austin Health, 145 Studley Road, Heidelberg, VIC, 3084, Australia.<br /><searchLink fieldCode="AU" term="%22Fowler+C%22">Fowler C</searchLink>; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Martins+RN%22">Martins RN</searchLink>; Australian Alzheimer's Research Foundation, Nedlands, WA, 6009, Australia.<br /><searchLink fieldCode="AU" term="%22Maruff+P%22">Maruff P</searchLink>; Cogstate Ltd, 161 Collins St, Melbourne, VIC, 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Sohrabi+HR%22">Sohrabi HR</searchLink>; Centre for Healthy Ageing, Health Futures Institute, Murdoch University, WA, 6150, Australia; School of Psychology, Murdoch University, WA, 6150, Australia.<br /><searchLink fieldCode="AU" term="%22Weiner+MW%22">Weiner MW</searchLink>; Department of Radiology, University of California at San Francisco, San Francisco, 505 Parnassus Avenue, San Francisco, CA, 94143, USA.<br /><searchLink fieldCode="AU" term="%22Morris+JC%22">Morris JC</searchLink>; Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA; Charles F. and Joanne Knight Alzheimer Disease Research Center (Knight ADRC), Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Benzinger+TLS%22">Benzinger TLS</searchLink>; Charles F. and Joanne Knight Alzheimer Disease Research Center (Knight ADRC), Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA; Department of Radiology, Washington University in St. Louis, 510 South Kingshighway Boulevard, St. Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Schindler+SE%22">Schindler SE</searchLink>; Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA; Charles F. and Joanne Knight Alzheimer Disease Research Center (Knight ADRC), Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Bateman+RJ%22">Bateman RJ</searchLink>; Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA; Charles F. and Joanne Knight Alzheimer Disease Research Center (Knight ADRC), Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA; Tracy Family SILQ Center, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Vitaliy+O%22">Vitaliy O</searchLink>; Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA; Tracy Family SILQ Center, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Ward+L%22">Ward L</searchLink>; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Mejan-Fripp+J%22">Mejan-Fripp J</searchLink>; The Australian e-Health Research Centre, CSIRO, 296 Herston Rd, Herston, Qld, 4029, Australia.<br /><searchLink fieldCode="AU" term="%22Masters+CL%22">Masters CL</searchLink>; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Villemagne+VL%22">Villemagne VL</searchLink>; Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, USA.<br /><searchLink fieldCode="AU" term="%22Rowe+CC%22">Rowe CC</searchLink>; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, VIC, 3052, Australia; Department of Molecular Imaging & Therapy, Austin Health, 145 Studley Road, Heidelberg, VIC, 3084, Australia. Electronic address: christopher.rowe@austin.org.au.
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  Data: <searchLink fieldCode="JN" term="%22101638820%22">The journal of prevention of Alzheimer's disease</searchLink> [J Prev Alzheimers Dis] 2026 Feb; Vol. 13 (2), pp. 100455. <i>Date of Electronic Publication: </i>2026 Jan 01.
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