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Polyserine domains are toxic and exacerbate tau pathology in mice.

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Title: Polyserine domains are toxic and exacerbate tau pathology in mice.
Authors: Van Alstyne M; Department of Biochemistry, University of Colorado, Boulder, CO 80303.; HHMI, University of Colorado, Boulder, CO 80303., Nguyen VL; Department of Biochemistry, University of Colorado, Boulder, CO 80303., Hoeffer CA; Department of Integrative Physiology, University of Colorado, Boulder, CO 80303., Parker R; Department of Biochemistry, University of Colorado, Boulder, CO 80303.; HHMI, University of Colorado, Boulder, CO 80303.; BioFrontiers Institute, University of Colorado, Boulder, CO 80303.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jan 06; Vol. 123 (1), pp. e2527425122. Date of Electronic Publication: 2026 Jan 02.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Van+Alstyne+M%22">Van Alstyne M</searchLink>; Department of Biochemistry, University of Colorado, Boulder, CO 80303.; HHMI, University of Colorado, Boulder, CO 80303.<br /><searchLink fieldCode="AU" term="%22Nguyen+VL%22">Nguyen VL</searchLink>; Department of Biochemistry, University of Colorado, Boulder, CO 80303.<br /><searchLink fieldCode="AU" term="%22Hoeffer+CA%22">Hoeffer CA</searchLink>; Department of Integrative Physiology, University of Colorado, Boulder, CO 80303.<br /><searchLink fieldCode="AU" term="%22Parker+R%22">Parker R</searchLink>; Department of Biochemistry, University of Colorado, Boulder, CO 80303.; HHMI, University of Colorado, Boulder, CO 80303.; BioFrontiers Institute, University of Colorado, Boulder, CO 80303.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 Jan 06; Vol. 123 (1), pp. e2527425122. <i>Date of Electronic Publication: </i>2026 Jan 02.
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        Value: 10.1073/pnas.2527425122
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      – TitleFull: Polyserine domains are toxic and exacerbate tau pathology in mice.
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              Text: 2026 Jan 06
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