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AI-assisted protein design to rapidly convert antibody sequences to intrabodies targeting diverse peptides and histone modifications.

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Title: AI-assisted protein design to rapidly convert antibody sequences to intrabodies targeting diverse peptides and histone modifications.
Authors: Galindo G; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA., Maejima D; School of Life Science and Technology, Institute of Science Tokyo, Yokohama, Japan., DeRoo J; School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA., Burlingham SR; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA., Fixen G; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA., Morisaki T; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA., Febvre HP; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA., Hasbrook R; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA., Zhao N; Department of Biochemistry and Molecular Genetics, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA., Ghosh S; School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA.; Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, USA., Mayton EH; Department of Microbiology, Immunology, & Pathology, Colorado State University, Fort Collins, CO, USA., Snow CD; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA.; School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA.; Department of Chemical & Biological Engineering, Colorado State University, Fort Collins, CO, USA., Geiss BJ; School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA.; Department of Microbiology, Immunology, & Pathology, Colorado State University, Fort Collins, CO, USA., Ohkawa Y; Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan., Sato Y; Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.; Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Japan., Kimura H; School of Life Science and Technology, Institute of Science Tokyo, Yokohama, Japan.; Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Japan.; Cell Biology Center, Institute of Integrated Research, Institute of Science Tokyo, Yokohama, Japan., Stasevich TJ; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA.; School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA.; Department of Chemical & Biological Engineering, Colorado State University, Fort Collins, CO, USA.; Cell Biology Center, Institute of Integrated Research, Institute of Science Tokyo, Yokohama, Japan.
Source: Science advances [Sci Adv] 2026 Jan 02; Vol. 12 (1), pp. eadx8352. Date of Electronic Publication: 2026 Jan 02.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: AI-assisted protein design to rapidly convert antibody sequences to intrabodies targeting diverse peptides and histone modifications.
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  Data: <searchLink fieldCode="AU" term="%22Galindo+G%22">Galindo G</searchLink>; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA.<br /><searchLink fieldCode="AU" term="%22Maejima+D%22">Maejima D</searchLink>; School of Life Science and Technology, Institute of Science Tokyo, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22DeRoo+J%22">DeRoo J</searchLink>; School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA.<br /><searchLink fieldCode="AU" term="%22Burlingham+SR%22">Burlingham SR</searchLink>; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA.<br /><searchLink fieldCode="AU" term="%22Fixen+G%22">Fixen G</searchLink>; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA.<br /><searchLink fieldCode="AU" term="%22Morisaki+T%22">Morisaki T</searchLink>; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA.<br /><searchLink fieldCode="AU" term="%22Febvre+HP%22">Febvre HP</searchLink>; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA.<br /><searchLink fieldCode="AU" term="%22Hasbrook+R%22">Hasbrook R</searchLink>; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+N%22">Zhao N</searchLink>; Department of Biochemistry and Molecular Genetics, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Ghosh+S%22">Ghosh S</searchLink>; School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA.; Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, USA.<br /><searchLink fieldCode="AU" term="%22Mayton+EH%22">Mayton EH</searchLink>; Department of Microbiology, Immunology, & Pathology, Colorado State University, Fort Collins, CO, USA.<br /><searchLink fieldCode="AU" term="%22Snow+CD%22">Snow CD</searchLink>; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA.; School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA.; Department of Chemical & Biological Engineering, Colorado State University, Fort Collins, CO, USA.<br /><searchLink fieldCode="AU" term="%22Geiss+BJ%22">Geiss BJ</searchLink>; School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA.; Department of Microbiology, Immunology, & Pathology, Colorado State University, Fort Collins, CO, USA.<br /><searchLink fieldCode="AU" term="%22Ohkawa+Y%22">Ohkawa Y</searchLink>; Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Sato+Y%22">Sato Y</searchLink>; Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.; Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Kimura+H%22">Kimura H</searchLink>; School of Life Science and Technology, Institute of Science Tokyo, Yokohama, Japan.; Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Japan.; Cell Biology Center, Institute of Integrated Research, Institute of Science Tokyo, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Stasevich+TJ%22">Stasevich TJ</searchLink>; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA.; School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA.; Department of Chemical & Biological Engineering, Colorado State University, Fort Collins, CO, USA.; Cell Biology Center, Institute of Integrated Research, Institute of Science Tokyo, Yokohama, Japan.
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