AI-assisted protein design to rapidly convert antibody sequences to intrabodies targeting diverse peptides and histone modifications.
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| Title: | AI-assisted protein design to rapidly convert antibody sequences to intrabodies targeting diverse peptides and histone modifications. |
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| Authors: | Galindo G; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA., Maejima D; School of Life Science and Technology, Institute of Science Tokyo, Yokohama, Japan., DeRoo J; School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA., Burlingham SR; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA., Fixen G; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA., Morisaki T; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA., Febvre HP; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA., Hasbrook R; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA., Zhao N; Department of Biochemistry and Molecular Genetics, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA., Ghosh S; School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA.; Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, USA., Mayton EH; Department of Microbiology, Immunology, & Pathology, Colorado State University, Fort Collins, CO, USA., Snow CD; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA.; School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA.; Department of Chemical & Biological Engineering, Colorado State University, Fort Collins, CO, USA., Geiss BJ; School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA.; Department of Microbiology, Immunology, & Pathology, Colorado State University, Fort Collins, CO, USA., Ohkawa Y; Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan., Sato Y; Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.; Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Japan., Kimura H; School of Life Science and Technology, Institute of Science Tokyo, Yokohama, Japan.; Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Japan.; Cell Biology Center, Institute of Integrated Research, Institute of Science Tokyo, Yokohama, Japan., Stasevich TJ; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA.; School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA.; Department of Chemical & Biological Engineering, Colorado State University, Fort Collins, CO, USA.; Cell Biology Center, Institute of Integrated Research, Institute of Science Tokyo, Yokohama, Japan. |
| Source: | Science advances [Sci Adv] 2026 Jan 02; Vol. 12 (1), pp. eadx8352. Date of Electronic Publication: 2026 Jan 02. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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