Tumor ecosystem and microbiome features associated with efficacy and resistance to avelumab plus chemoradiotherapy in head and neck cancer.

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Title: Tumor ecosystem and microbiome features associated with efficacy and resistance to avelumab plus chemoradiotherapy in head and neck cancer.
Authors: Riaz N; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Alban TJ; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA., Haddad RI; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA., Saul M; Pfizer, La Jolla, CA, USA., Makarov V; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA., Zhu Y; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Cohen EEW; Moores Cancer Center, University of California San Diego Health, La Jolla, CA, USA., Ferris RL; UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Chang PM; Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan., Lin JC; Department of Radiation Oncology, Changhua Christian Hospital, Changhua, Taiwan., Psyrri A; National Kapodistrian University of Athens, Athens, Greece., Parthasarathy PB; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA., Novaj A; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Gawali M; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA., Hoen D; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA., Hamilton P; Pfizer, La Jolla, CA, USA., Silver NL; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA., Juric I; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA., Chawla D; Pfizer, La Jolla, CA, USA., Gradissimo A; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ko J; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA., McGrail DJ; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA., Davis CB; Pfizer, La Jolla, CA, USA. craig.davis@pfizer.com., Lee NY; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. leen2@mskcc.org., Chan TA; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA. chant2@ccf.org.; National Center for Regenerative Medicine, Cleveland, OH, USA. chant2@ccf.org.
Source: Nature cancer [Nat Cancer] 2026 Jan; Vol. 7 (1), pp. 98-115. Date of Electronic Publication: 2026 Jan 02.
Publication Type: Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Riaz+N%22">Riaz N</searchLink>; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Alban+TJ%22">Alban TJ</searchLink>; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Haddad+RI%22">Haddad RI</searchLink>; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Saul+M%22">Saul M</searchLink>; Pfizer, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Makarov+V%22">Makarov V</searchLink>; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Cohen+EEW%22">Cohen EEW</searchLink>; Moores Cancer Center, University of California San Diego Health, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ferris+RL%22">Ferris RL</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Chang+PM%22">Chang PM</searchLink>; Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+JC%22">Lin JC</searchLink>; Department of Radiation Oncology, Changhua Christian Hospital, Changhua, Taiwan.<br /><searchLink fieldCode="AU" term="%22Psyrri+A%22">Psyrri A</searchLink>; National Kapodistrian University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Parthasarathy+PB%22">Parthasarathy PB</searchLink>; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Novaj+A%22">Novaj A</searchLink>; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Gawali+M%22">Gawali M</searchLink>; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Hoen+D%22">Hoen D</searchLink>; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Hamilton+P%22">Hamilton P</searchLink>; Pfizer, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Silver+NL%22">Silver NL</searchLink>; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Juric+I%22">Juric I</searchLink>; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Chawla+D%22">Chawla D</searchLink>; Pfizer, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gradissimo+A%22">Gradissimo A</searchLink>; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ko+J%22">Ko J</searchLink>; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22McGrail+DJ%22">McGrail DJ</searchLink>; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Davis+CB%22">Davis CB</searchLink>; Pfizer, La Jolla, CA, USA. craig.davis@pfizer.com.<br /><searchLink fieldCode="AU" term="%22Lee+NY%22">Lee NY</searchLink>; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. leen2@mskcc.org.<br /><searchLink fieldCode="AU" term="%22Chan+TA%22">Chan TA</searchLink>; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA. chant2@ccf.org.; National Center for Regenerative Medicine, Cleveland, OH, USA. chant2@ccf.org.
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  Data: <searchLink fieldCode="JN" term="%22101761119%22">Nature cancer</searchLink> [Nat Cancer] 2026 Jan; Vol. 7 (1), pp. 98-115. <i>Date of Electronic Publication: </i>2026 Jan 02.
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