Tumor ecosystem and microbiome features associated with efficacy and resistance to avelumab plus chemoradiotherapy in head and neck cancer.
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| Title: | Tumor ecosystem and microbiome features associated with efficacy and resistance to avelumab plus chemoradiotherapy in head and neck cancer. |
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| Authors: | Riaz N; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Alban TJ; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA., Haddad RI; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA., Saul M; Pfizer, La Jolla, CA, USA., Makarov V; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA., Zhu Y; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Cohen EEW; Moores Cancer Center, University of California San Diego Health, La Jolla, CA, USA., Ferris RL; UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Chang PM; Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan., Lin JC; Department of Radiation Oncology, Changhua Christian Hospital, Changhua, Taiwan., Psyrri A; National Kapodistrian University of Athens, Athens, Greece., Parthasarathy PB; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA., Novaj A; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Gawali M; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA., Hoen D; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA., Hamilton P; Pfizer, La Jolla, CA, USA., Silver NL; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA., Juric I; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA., Chawla D; Pfizer, La Jolla, CA, USA., Gradissimo A; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ko J; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA., McGrail DJ; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA., Davis CB; Pfizer, La Jolla, CA, USA. craig.davis@pfizer.com., Lee NY; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. leen2@mskcc.org., Chan TA; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA. chant2@ccf.org.; National Center for Regenerative Medicine, Cleveland, OH, USA. chant2@ccf.org. |
| Source: | Nature cancer [Nat Cancer] 2026 Jan; Vol. 7 (1), pp. 98-115. Date of Electronic Publication: 2026 Jan 02. |
| Publication Type: | Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41482527 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Tumor ecosystem and microbiome features associated with efficacy and resistance to avelumab plus chemoradiotherapy in head and neck cancer. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Riaz+N%22">Riaz N</searchLink>; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Alban+TJ%22">Alban TJ</searchLink>; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Haddad+RI%22">Haddad RI</searchLink>; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Saul+M%22">Saul M</searchLink>; Pfizer, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Makarov+V%22">Makarov V</searchLink>; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Cohen+EEW%22">Cohen EEW</searchLink>; Moores Cancer Center, University of California San Diego Health, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ferris+RL%22">Ferris RL</searchLink>; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Chang+PM%22">Chang PM</searchLink>; Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+JC%22">Lin JC</searchLink>; Department of Radiation Oncology, Changhua Christian Hospital, Changhua, Taiwan.<br /><searchLink fieldCode="AU" term="%22Psyrri+A%22">Psyrri A</searchLink>; National Kapodistrian University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Parthasarathy+PB%22">Parthasarathy PB</searchLink>; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Novaj+A%22">Novaj A</searchLink>; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Gawali+M%22">Gawali M</searchLink>; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Hoen+D%22">Hoen D</searchLink>; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Hamilton+P%22">Hamilton P</searchLink>; Pfizer, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Silver+NL%22">Silver NL</searchLink>; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Juric+I%22">Juric I</searchLink>; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Chawla+D%22">Chawla D</searchLink>; Pfizer, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gradissimo+A%22">Gradissimo A</searchLink>; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ko+J%22">Ko J</searchLink>; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22McGrail+DJ%22">McGrail DJ</searchLink>; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Davis+CB%22">Davis CB</searchLink>; Pfizer, La Jolla, CA, USA. craig.davis@pfizer.com.<br /><searchLink fieldCode="AU" term="%22Lee+NY%22">Lee NY</searchLink>; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. leen2@mskcc.org.<br /><searchLink fieldCode="AU" term="%22Chan+TA%22">Chan TA</searchLink>; Department of Cancer Sciences and Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA. chant2@ccf.org.; National Center for Regenerative Medicine, Cleveland, OH, USA. chant2@ccf.org. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101761119%22">Nature cancer</searchLink> [Nat Cancer] 2026 Jan; Vol. 7 (1), pp. 98-115. <i>Date of Electronic Publication: </i>2026 Jan 02. – Name: TypePub Label: Publication Type Group: TypPub Data: Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101761119 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2662-1347 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226621347%22">26621347 </searchLink><i>NLM ISO Abbreviation: </i>Nat Cancer <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41482527 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s43018-025-01068-0 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 98 Titles: – TitleFull: Tumor ecosystem and microbiome features associated with efficacy and resistance to avelumab plus chemoradiotherapy in head and neck cancer. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Riaz N – PersonEntity: Name: NameFull: Alban TJ – PersonEntity: Name: NameFull: Haddad RI – PersonEntity: Name: NameFull: Saul M – PersonEntity: Name: NameFull: Makarov V – PersonEntity: Name: NameFull: Zhu Y – PersonEntity: Name: NameFull: Cohen EEW – PersonEntity: Name: NameFull: Ferris RL – PersonEntity: Name: NameFull: Chang PM – PersonEntity: Name: NameFull: Lin JC – PersonEntity: Name: NameFull: Psyrri A – PersonEntity: Name: NameFull: Parthasarathy PB – PersonEntity: Name: NameFull: Novaj A – PersonEntity: Name: NameFull: Gawali M – PersonEntity: Name: NameFull: Hoen D – PersonEntity: Name: NameFull: Hamilton P – PersonEntity: Name: NameFull: Silver NL – PersonEntity: Name: NameFull: Juric I – PersonEntity: Name: NameFull: Chawla D – PersonEntity: Name: NameFull: Gradissimo A – PersonEntity: Name: NameFull: Ko J – PersonEntity: Name: NameFull: McGrail DJ – PersonEntity: Name: NameFull: Davis CB – PersonEntity: Name: NameFull: Lee NY – PersonEntity: Name: NameFull: Chan TA IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: 2026 Jan Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2662-1347 Numbering: – Type: volume Value: 7 – Type: issue Value: 1 Titles: – TitleFull: Nature cancer Type: main |
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