SOX4-STAT6-MTHFD2 axis drives hepatocellular carcinoma progression and treatment resistance.
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| Title: | SOX4-STAT6-MTHFD2 axis drives hepatocellular carcinoma progression and treatment resistance. |
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| Authors: | Tsai CL; Genomic Medicine Core Laboratory, Linkou Chang-Gung Memorial Hospital, Taoyuan City, 33305, Taiwan., Yu MC; Department of Surgery, New Taipei Municipal Tucheng Hospital (Built and operated by Chang-Gung Medical Foundation), New Taipei City, 23652, Taiwan.; School of Medicine, College of Medicine, Chang-Gung University, Taoyuan City, 33302, Taiwan., Hsu CL; School of Medicine, College of Medicine, Chang-Gung University, Taoyuan City, 33302, Taiwan.; Division of Hematology-Oncology, Department of Internal Medicine, Chang-Gung Memorial Hospital, Taoyuan City, 33305, Taiwan., Tang HY; Metabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung University, Taoyuan, 33302, Taiwan., Lee YS; Department of Biotechnology, Ming Chuan University, Taoyuan, 33348, Taiwan., Chi LM; Molecular Medicine Research Center, Chang-Gung University, Taoyuan City, 33302, Taiwan., Lin SE; Department of Anatomical Pathology, Taipei Institute of Pathology, Taipei City, 10372, Taiwan., Cheng ML; Metabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung University, Taoyuan, 33302, Taiwan.; Department of Biomedical Sciences, Chang-Gung University, Taoyuan City, 33302, Taiwan., Hsu HY; Department of Surgery, New Taipei Municipal Tucheng Hospital (Built and operated by Chang-Gung Medical Foundation), New Taipei City, 23652, Taiwan.; School of Medicine, College of Medicine, Chang-Gung University, Taoyuan City, 33302, Taiwan., Tsai CN; Department of Surgery, New Taipei Municipal Tucheng Hospital (Built and operated by Chang-Gung Medical Foundation), New Taipei City, 23652, Taiwan. pink7@mail.cgu.edu.tw.; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang-Gung University, Taoyuan City, 33302, Taiwan. pink7@mail.cgu.edu.tw. |
| Source: | Cell death & disease [Cell Death Dis] 2026 Jan 03; Vol. 17 (1), pp. 154. Date of Electronic Publication: 2026 Jan 03. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-4889 |
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| DOI: | 10.1038/s41419-025-08394-2 |
