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SOX4-STAT6-MTHFD2 axis drives hepatocellular carcinoma progression and treatment resistance.

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Title: SOX4-STAT6-MTHFD2 axis drives hepatocellular carcinoma progression and treatment resistance.
Authors: Tsai CL; Genomic Medicine Core Laboratory, Linkou Chang-Gung Memorial Hospital, Taoyuan City, 33305, Taiwan., Yu MC; Department of Surgery, New Taipei Municipal Tucheng Hospital (Built and operated by Chang-Gung Medical Foundation), New Taipei City, 23652, Taiwan.; School of Medicine, College of Medicine, Chang-Gung University, Taoyuan City, 33302, Taiwan., Hsu CL; School of Medicine, College of Medicine, Chang-Gung University, Taoyuan City, 33302, Taiwan.; Division of Hematology-Oncology, Department of Internal Medicine, Chang-Gung Memorial Hospital, Taoyuan City, 33305, Taiwan., Tang HY; Metabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung University, Taoyuan, 33302, Taiwan., Lee YS; Department of Biotechnology, Ming Chuan University, Taoyuan, 33348, Taiwan., Chi LM; Molecular Medicine Research Center, Chang-Gung University, Taoyuan City, 33302, Taiwan., Lin SE; Department of Anatomical Pathology, Taipei Institute of Pathology, Taipei City, 10372, Taiwan., Cheng ML; Metabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung University, Taoyuan, 33302, Taiwan.; Department of Biomedical Sciences, Chang-Gung University, Taoyuan City, 33302, Taiwan., Hsu HY; Department of Surgery, New Taipei Municipal Tucheng Hospital (Built and operated by Chang-Gung Medical Foundation), New Taipei City, 23652, Taiwan.; School of Medicine, College of Medicine, Chang-Gung University, Taoyuan City, 33302, Taiwan., Tsai CN; Department of Surgery, New Taipei Municipal Tucheng Hospital (Built and operated by Chang-Gung Medical Foundation), New Taipei City, 23652, Taiwan. pink7@mail.cgu.edu.tw.; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang-Gung University, Taoyuan City, 33302, Taiwan. pink7@mail.cgu.edu.tw.
Source: Cell death & disease [Cell Death Dis] 2026 Jan 03; Vol. 17 (1), pp. 154. Date of Electronic Publication: 2026 Jan 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: SOX4-STAT6-MTHFD2 axis drives hepatocellular carcinoma progression and treatment resistance.
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  Data: <searchLink fieldCode="AU" term="%22Tsai+CL%22">Tsai CL</searchLink>; Genomic Medicine Core Laboratory, Linkou Chang-Gung Memorial Hospital, Taoyuan City, 33305, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yu+MC%22">Yu MC</searchLink>; Department of Surgery, New Taipei Municipal Tucheng Hospital (Built and operated by Chang-Gung Medical Foundation), New Taipei City, 23652, Taiwan.; School of Medicine, College of Medicine, Chang-Gung University, Taoyuan City, 33302, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsu+CL%22">Hsu CL</searchLink>; School of Medicine, College of Medicine, Chang-Gung University, Taoyuan City, 33302, Taiwan.; Division of Hematology-Oncology, Department of Internal Medicine, Chang-Gung Memorial Hospital, Taoyuan City, 33305, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tang+HY%22">Tang HY</searchLink>; Metabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung University, Taoyuan, 33302, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+YS%22">Lee YS</searchLink>; Department of Biotechnology, Ming Chuan University, Taoyuan, 33348, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chi+LM%22">Chi LM</searchLink>; Molecular Medicine Research Center, Chang-Gung University, Taoyuan City, 33302, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+SE%22">Lin SE</searchLink>; Department of Anatomical Pathology, Taipei Institute of Pathology, Taipei City, 10372, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+ML%22">Cheng ML</searchLink>; Metabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung University, Taoyuan, 33302, Taiwan.; Department of Biomedical Sciences, Chang-Gung University, Taoyuan City, 33302, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsu+HY%22">Hsu HY</searchLink>; Department of Surgery, New Taipei Municipal Tucheng Hospital (Built and operated by Chang-Gung Medical Foundation), New Taipei City, 23652, Taiwan.; School of Medicine, College of Medicine, Chang-Gung University, Taoyuan City, 33302, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+CN%22">Tsai CN</searchLink>; Department of Surgery, New Taipei Municipal Tucheng Hospital (Built and operated by Chang-Gung Medical Foundation), New Taipei City, 23652, Taiwan. pink7@mail.cgu.edu.tw.; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang-Gung University, Taoyuan City, 33302, Taiwan. pink7@mail.cgu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2026 Jan 03; Vol. 17 (1), pp. 154. <i>Date of Electronic Publication: </i>2026 Jan 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101524092 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-4889 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Death Dis <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41484064
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        Value: 10.1038/s41419-025-08394-2
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              Text: 2026 Jan 03
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