Bidirectional Mendelian randomization of leukocyte counts, renal function, and Lipocalin-2 Levels: disentangling the genetic links, causal pathways and cardiovascular outcomes.

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Title: Bidirectional Mendelian randomization of leukocyte counts, renal function, and Lipocalin-2 Levels: disentangling the genetic links, causal pathways and cardiovascular outcomes.
Authors: Hsu LA; Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan., Tran NY; Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan., Juang JJ; Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; College of Medicine, National Taiwan University, Taipei, Taiwan., Chiang FT; Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; College of Medicine, National Taiwan University, Taipei, Taiwan.; Division of Cardiology, Cardiovascular Center, Fu-Jen Catholic University Hospital, New Taipei City, Taiwan., Wu S; Department of Life Science, Chinese Culture University, Taipei, Taiwan., Ko YL; Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. yulinkotw@gmail.com.; School of Medicine, Tzu Chi University, Hualien, Taiwan. yulinkotw@gmail.com.; Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. yulinkotw@gmail.com.
Source: Journal of human genetics [J Hum Genet] 2026 Jun; Vol. 71 (6), pp. 343-352. Date of Electronic Publication: 2026 Jan 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 9808008 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-232X (Electronic) Linking ISSN: 14345161 NLM ISO Abbreviation: J Hum Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Hsu+LA%22">Hsu LA</searchLink>; Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tran+NY%22">Tran NY</searchLink>; Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Juang+JJ%22">Juang JJ</searchLink>; Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiang+FT%22">Chiang FT</searchLink>; Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; College of Medicine, National Taiwan University, Taipei, Taiwan.; Division of Cardiology, Cardiovascular Center, Fu-Jen Catholic University Hospital, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+S%22">Wu S</searchLink>; Department of Life Science, Chinese Culture University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ko+YL%22">Ko YL</searchLink>; Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. yulinkotw@gmail.com.; School of Medicine, Tzu Chi University, Hualien, Taiwan. yulinkotw@gmail.com.; Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. yulinkotw@gmail.com.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9808008 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1435-232X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214345161%22">14345161 </searchLink><i>NLM ISO Abbreviation: </i>J Hum Genet <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s10038-025-01445-8
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        StartPage: 343
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      – TitleFull: Bidirectional Mendelian randomization of leukocyte counts, renal function, and Lipocalin-2 Levels: disentangling the genetic links, causal pathways and cardiovascular outcomes.
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              Text: 2026 Jun
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